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Murcko scaffold

Ring system with 3 rings and 23 atoms

52 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
52
With full pages
10
Scaffold SMILES

O=C(Nc1ccccc1)Nc1ccc(Oc2ccncc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1ccc(Oc2ccncc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

Sorafenib chemical structure, C21H16ClF3N4O3, CAS 284461-73-0
Sorafenib
CAS 284461-73-0C21H16ClF3N4O3
Sorafenib tosylate chemical structure, C28H24ClF3N4O6S, CAS 475207-59-1
Sorafenib tosylate
CAS 475207-59-1C28H24ClF3N4O6S
3-[4-Chloro-3-(trifluoromethyl)phenyl]-1-[4-(pyridin-4-yloxy)phenyl]urea chemical structure, C19H13ClF3N3O2, CAS 228400-44-0
3-[4-Chloro-3-(trifluoromethyl)phenyl]-1-[4-(pyridin-4-yloxy)phenyl]urea
CAS 228400-44-0C19H13ClF3N3O2
Sorafenib N-oxide chemical structure, C21H16ClF3N4O4, CAS 583840-03-3
Sorafenib N-oxide
CAS 583840-03-3C21H16ClF3N4O4
4-(4-(3-(4-Bromo-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide chemical structure, C21H16BrF3N4O3, CAS 284462-18-6
4-(4-(3-(4-Bromo-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
CAS 284462-18-6C21H16BrF3N4O3
1-(4-Ethylphenyl)-3-(4-pyridin-4-yloxyphenyl)urea chemical structure, C20H19N3O2, CAS 630122-37-1
1-(4-Ethylphenyl)-3-(4-pyridin-4-yloxyphenyl)urea
CAS 630122-37-1C20H19N3O2
4-(4-(3-(2-Methoxy-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide chemical structure, C22H19F3N4O4, CAS 284461-44-5
4-(4-(3-(2-Methoxy-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
CAS 284461-44-5C22H19F3N4O4
N-Desmethyl sorafenib chemical structure, C20H14ClF3N4O3, CAS 284461-74-1
N-Desmethyl sorafenib
CAS 284461-74-1C20H14ClF3N4O3
Sorafenib metabolite M-1 chemical structure, C21H16ClF3N4O5, CAS 583840-05-5
Sorafenib metabolite M-1
CAS 583840-05-5C21H16ClF3N4O5
1-(4-(2-(Isopropylcarbamoyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-5-(trifluoromethyl)-2-methoxyphenyl)urea chemical structure, C24H22ClF3N4O4, CAS 447457-09-2
1-(4-(2-(Isopropylcarbamoyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-5-(trifluoromethyl)-2-methoxyphenyl)urea
CAS 447457-09-2C24H22ClF3N4O4
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-ethylpicolinamide chemical structure, C22H18ClF3N4O3, CAS 284461-82-1
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-ethylpicolinamide
CAS 284461-82-1C22H18ClF3N4O3
Methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate chemical structure, C21H15ClF3N3O4, CAS 573673-43-5
Methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate
CAS 573673-43-5C21H15ClF3N3O4
N-Desmethyl Sorafenib (Pyridine)-N-oxide chemical structure, C20H14ClF3N4O4, CAS 583840-04-4
N-Desmethyl Sorafenib (Pyridine)-N-oxide
CAS 583840-04-4C20H14ClF3N4O4
1-[4-Bromo-3-(trifluoromethyl)phenyl]-3-(4-pyridin-4-yloxyphenyl)urea chemical structure, C19H13BrF3N3O2, CAS 228400-61-1
1-[4-Bromo-3-(trifluoromethyl)phenyl]-3-(4-pyridin-4-yloxyphenyl)urea
CAS 228400-61-1C19H13BrF3N3O2
Regorafenib chemical structure, C21H15ClF4N4O3, CAS 755037-03-7
Regorafenib
CAS 755037-03-7C21H15ClF4N4O3
Sorafenib impurity 9 chemical structure, C21H17F3N4O4, CAS 862875-16-9
Sorafenib impurity 9
CAS 862875-16-9C21H17F3N4O4
1-(4-(Pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea chemical structure, C19H14F3N3O2, CAS 228400-22-4
1-(4-(Pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
CAS 228400-22-4C19H14F3N3O2
Regorafenib monohydrate chemical structure, C21H17ClF4N4O4, CAS 1019206-88-2
Regorafenib monohydrate
CAS 1019206-88-2C21H17ClF4N4O4
Donafenib chemical structure, C21H16ClF3N4O3, CAS 1130115-44-4
Donafenib
CAS 1130115-44-4C21H16ClF3N4O3
N-Desmethyl N-methoxy regorafenib chemical structure, C21H15ClF4N4O4, CAS 1187944-98-4
N-Desmethyl N-methoxy regorafenib
CAS 1187944-98-4C21H15ClF4N4O4
Sorafenib hydrobromide chemical structure, C21H17BrClF3N4O3, CAS 1199618-58-0
Sorafenib hydrobromide
CAS 1199618-58-0C21H17BrClF3N4O3
Sorafenib hydrochloride chemical structure, C21H17Cl2F3N4O3, CAS 1199618-57-9
Sorafenib hydrochloride
CAS 1199618-57-9C21H17Cl2F3N4O3
Sorafenib-d4 chemical structure, C21H16ClF3N4O3, CAS 1207560-07-3
Sorafenib-d4
CAS 1207560-07-3C21H16ClF3N4O3
Regorafenib-d3 chemical structure, C21H15ClF4N4O3, CAS 1255386-16-3
Regorafenib-d3
CAS 1255386-16-3C21H15ClF4N4O3