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Screening compounds

Remibrutinib

Also known as N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide, Benzamide, N-(3-(6-amino-5-(2-(methyl(1-oxo-2-propen-1-yl)amino)ethoxy)-4-pyrimidinyl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluoro-

CAS 1787294-07-8Formula C27H27F2N5O3Molar mass 507.54 g/molEC 188-778-9
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Remibrutinib chemical structure, C27H27F2N5O3, CAS 1787294-07-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1787294-07-8
Formula
C27H27F2N5O3
Molar mass
507.54 g/mol
EC number
188-778-9
HS code
293359
Category
Screening compounds

What is Remibrutinib?

Plain description, key identifiers and synonyms

Remibrutinib is a Kinase Inhibitor. The mechanism of action of remibrutinib is as a Bruton's Tyrosine Kinase Inhibitor and P-Glycoprotein Inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
CAS number
1787294-07-8
EC number
188-778-9
Molecular formula
C27H27F2N5O3
UNII
I7MVZ8HDNU
MDL number
MFCD32215329
InChIKey
CUABMPOJOBCXJI-UHFFFAOYSA-N
InChI
InChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)
SMILES (canonical and isomeric)
CC1=C(C=C(C=C1NC(=O)C2=C(C=C(C=C2)C3CC3)F)F)C4=C(C(=NC=N4)N)OCCN(C)C(=O)C=C

Synonyms

  • N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
  • N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
  • Benzamide, N-(3-(6-amino-5-(2-(methyl(1-oxo-2-propen-1-yl)amino)ethoxy)-4-pyrimidinyl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluoro-
  • N-(3-(6-amino-5-(2-(methyl(prop-2-enoyl)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
  • N-[3-[6-Amino-5-[2-(N-methylacrylamido)ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
  • Rhapsido
  • Remibrutinib (LOU064)
  • N-[3-[6-Amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
  • Rhapsido (TN)
  • Remibrutinib (LOU064)?
  • Remibrutinib (JAN/USAN/INN)
  • WHO 11062
  • example 6
  • compound 25
  • US9512084, 6
  • N-[3-[6-Amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylpheny
  • N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methyl-phenyl]-4-cyclopropyl-2-fluoro-benzamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
507.54 g/molcalc.
Exact mass
507.2082 Dacalc.
LogP (octanol/water)
4.47calc.
Topological polar surface area
110.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
9calc.
Heavy atoms
37calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1cccc(-c2ccncn2)c1)c1ccc(C2CC2)cc1

O=C(Nc1cccc(-c2ccncn2)c1)c1ccc(C2CC2)cc1

4 rings, 24 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Remibrutinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 2 countries

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Remibrutinib price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Tyrosine Kinase Inhibitors

Roles

  • enzyme inhibitor
  • immunomodulator
  • immunosuppressive agent
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Remibrutinib is an oral Bruton tyrosine kinase inhibitor that is used in the treatment of chronic spontaneous urticaria in adults who remain symptomatic despite antihistamine therapy. Remibrutinib has been associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent liver injury.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Remibrutinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Remibrutinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Remibrutinib, based on the data on this page

What is Remibrutinib?

Remibrutinib is a Kinase Inhibitor. The mechanism of action of remibrutinib is as a Bruton's Tyrosine Kinase Inhibitor and P-Glycoprotein Inhibitor.

What is the CAS number of Remibrutinib?

The CAS registry number of Remibrutinib is 1787294-07-8.

What is the molecular formula and weight of Remibrutinib?

The molecular formula of Remibrutinib is C27H27F2N5O3 and its molar mass is 507.54 g/mol.

What is Remibrutinib used for?

Known uses and roles of Remibrutinib include building blocks in research and laboratory, screening compounds in research and laboratory, enzyme inhibitor, immunomodulator, immunosuppressive agent and 4 more.

Is Remibrutinib hazardous?

No GHS hazard classification for Remibrutinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Remibrutinib?

Remibrutinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Remibrutinib?

CompoundList lists 4 suppliers of Remibrutinib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Remibrutinib?

Suppliers quote Remibrutinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Remibrutinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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