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Heterocyclic building blocks

RepSox

Also known as SJN 2511, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, ALK5 Inhibitor II

CAS 446859-33-2Formula C17H13N5Molar mass 287.33 g/molEC 663-924-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 13 suppliers listed
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RepSox chemical structure, C17H13N5, CAS 446859-33-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
446859-33-2
Formula
C17H13N5
Molar mass
287.33 g/mol
EC number
663-924-9
HS code
293339
Category
Heterocyclic building blocks

What is RepSox?

Plain description, key identifiers and synonyms

RepSox is a member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a TGFbeta receptor antagonist. It is a member of pyrazoles, a member of pyridines and a 1,5-naphthyridine derivative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
CAS number
446859-33-2 CAS number cross-checked
EC number
663-924-9
Molecular formula
C17H13N5
UNII
JT8ZW3H2ST
MDL number
MFCD09037561
InChIKey
LBPKYPYHDKKRFS-UHFFFAOYSA-N
InChI
InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
SMILES (canonical and isomeric)
CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Synonyms

  • SJN 2511
  • 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
  • ALK5 Inhibitor II
  • ALK5 Inhibitor
  • 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • Alk 5 Inhibitor II
  • RepSox (GMP)
  • 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
  • 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
  • 2-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • 2-(3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl)-1,5-naphthyridine
  • 1vjy
  • 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, E 616452, RepSox, SJN 2511
  • RepsoxALK5 Inhibitor II
  • RepsoxALK5 Inhibitor II?
  • RepSox (ALK5 Inhibitor II)
  • RepSox (E-616452)
  • RepSox, >=98% (HPLC)
  • Sdccggsk-0000063.p001
  • GW786460X (616452)
  • 4-(1,5-Diaza-2-naphthyl)-3-(6-methyl-2-pyridyl)pyrazole
  • 2-[3-(6-Methyl-2-pyridyl)-4-pyrazolyl]-1,5-naphthyridine
  • 2-[5-(6-methyl-2-pyridyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • 2-(3-(6-Methylpyridine-2-yl)-1H-pyr azol-4-yl)-1,5-naphthyridine
Show all 28 synonyms
  • 2-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-[1,5]naphthyridine
  • Alk 5 Inhibitor II (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine)
  • TGF-beta RI kinase inhibitor II (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
287.33 g/molcalc.
Exact mass
287.1171 Dacalc.
LogP (octanol/water)
3.39calc.
Topological polar surface area
67.35 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.06calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2[nH]ncc2-c2ccc3ncccc3n2)nc1

c1ccc(-c2[nH]ncc2-c2ccc3ncccc3n2)nc1

4 rings, 21 atoms, the 2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-1,5-naphthyridine ring system.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

RepSox suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
13 of 13 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

13 suppliers in 3 countries

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RepSox price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • TGFbeta receptor antagonist
  • antagonist
  • antineoplastic agent
  • bone density conservation agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code RepSox is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for RepSox is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about RepSox, based on the data on this page

What is RepSox?

RepSox is a member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM).

What is the CAS number of RepSox?

The CAS registry number of RepSox is 446859-33-2.

What is the molecular formula and weight of RepSox?

The molecular formula of RepSox is C17H13N5 and its molar mass is 287.33 g/mol.

What is RepSox used for?

Known uses and roles of RepSox include building blocks in research and laboratory, screening compounds in research and laboratory, tgfbeta receptor antagonist, antagonist, antineoplastic agent and 5 more.

Is RepSox hazardous?

RepSox carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of RepSox?

RepSox is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy RepSox?

CompoundList lists 13 suppliers of RepSox in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of RepSox?

Suppliers quote RepSox on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle RepSox

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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