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Phenols

Rhapontigenin

Also known as Protigenin, Pontigenin, Rhapontin genin

CAS 500-65-2Formula C15H14O4Molar mass 258.27 g/mol
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Rhapontigenin chemical structure, C15H14O4, CAS 500-65-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
500-65-2
Formula
C15H14O4
Molar mass
258.27 g/mol
HS code
290950
Category
Phenols

What is Rhapontigenin?

Plain description, key identifiers and synonyms

Rhapontigenin is a stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 5, while the other phenyl group is substituted by a hydroxy group at position 3 and a methoxy group at position 4. It has a role as a quorum sensing inhibitor, an antiviral agent, an antibacterial agent, an antineoplastic agent, an antilipemic drug, an antifungal agent, an angiogenesis inhibitor, a radical scavenger, a P450 inhibitor, a melanin synthesis inhibitor, a plant metabolite and a cardioprotective agent. It is a member of guaiacols, a polyphenol, a member of resorcinols and a stilbenol. It is functionally related to a piceatannol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
CAS number
500-65-2 CAS number cross-checked
Molecular formula
C15H14O4
UNII
22BG4NNH6W
MDL number
MFCD00017718
InChIKey
PHMHDRYYFAYWEG-NSCUHMNNSA-N
InChI
InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+
Canonical SMILES
COc1ccc(C=Cc2cc(O)cc(O)c2)cc1O
Isomeric SMILES
COC1=C(C=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O)O

Synonyms

  • Protigenin
  • Pontigenin
  • Rhapontin genin
  • 5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
  • 5-((E)-2-(3-Hydroxy-4-methoxyphenyl)ethenyl)benzene-1,3-diol
  • (E)-5-(3-Hydroxy-4-methoxystyryl)benzene-1,3-diol
  • Prontigenin
  • 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
  • Rhapontin aglycone
  • 5-[(1E)-2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
  • 3,3',5-trihydroxy-4'-methoxystilbene
  • ?rhapontig
  • 5-((1E)-2-(3-Hydroxy-4-methoxyphenyl)ethenyl)-1,3-benzenediol
  • 4'-Methoxy-3,3',5-trihydroxystilbene
  • (E)-rhapontigenin
  • Rhapontigenin [M+H]+
  • Rhapontigenin (Standard)
  • piceatannol 4'-methyl ether
  • 5-[(E)-2-(3-hydroxy-4-methoxy-phenyl)vinyl]benzene-1,3-diol
  • trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene
  • (E)-3,3',5-trihydroxy-4'-methoxystibene
  • 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene
  • 3,3,5-Stilbenetriol, 4-methoxy-, (E)-
  • 1,3-Benzenediol, 5-((1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)-
  • 1,3-Benzenediol, 5-(2-(3-hydroxy-4-methoxyphenyl)ethenyl)-, (E)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
258.27 g/molcalc.
Exact mass
258.0892 Dacalc.
LogP (octanol/water)
2.98calc.
Topological polar surface area
69.92 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=Cc1ccccc1)c1ccccc1

C(=Cc1ccccc1)c1ccccc1

2 rings, 14 atoms, the Stilbene ring system.

2,005 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rhapontigenin suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 1 country

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Rhapontigenin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • P450 inhibitor
  • angiogenesis inhibitor
  • antibacterial agent
  • antifungal agent
  • antilipemic drug
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • antiviral agent
  • cardioprotective agent
  • depigmentation drug
  • enzyme inhibitor
  • eukaryotic metabolite
  • melanin synthesis inhibitor
  • metabolite
  • pharmaceutical
  • plant metabolite
  • protective agent
  • quorum sensing inhibitor
  • radical scavenger

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rhapontigenin is traded under.

HS 2909.50Indicative HS code

Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…

World exports in 2024
$284M
+11.9% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. India * partner reported32.9%
  2. Indonesia17.7%
  3. France * partner reported11.2%
Top importers
  1. China20.7%
  2. United States12.0%
  3. Brazil6.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rhapontigenin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rhapontigenin, based on the data on this page

What is Rhapontigenin?

Rhapontigenin is a stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 5, while the other phenyl group is substituted by a hydroxy group at position 3 and a methoxy group at position 4.

What is the CAS number of Rhapontigenin?

The CAS registry number of Rhapontigenin is 500-65-2.

What is the molecular formula and weight of Rhapontigenin?

The molecular formula of Rhapontigenin is C15H14O4 and its molar mass is 258.27 g/mol.

What is Rhapontigenin used for?

Known uses and roles of Rhapontigenin include p450 inhibitor, angiogenesis inhibitor, antibacterial agent, antifungal agent, antilipemic drug and 15 more.

Is Rhapontigenin hazardous?

No GHS hazard classification for Rhapontigenin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Rhapontigenin?

Rhapontigenin is usually classified under HS code 290950 (Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rhapontigenin?

CompoundList lists 2 suppliers of Rhapontigenin in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Rhapontigenin?

Suppliers quote Rhapontigenin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rhapontigenin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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