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Pharmaceuticals and APIs

Rizatriptan benzoate

Also known as Maxalt-MLT, Rizafilm, 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, monobenzoate

CAS 145202-66-0Formula C22H25N5O2Molar mass 391.48 g/molEC 604-465-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 90 suppliers listed Drug substance
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Rizatriptan benzoate chemical structure, C22H25N5O2, CAS 145202-66-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
145202-66-0
Formula
C22H25N5O2
Molar mass
391.48 g/mol
EC number
604-465-6
HS code
293399
Category
Pharmaceuticals and APIs

What is Rizatriptan benzoate?

Plain description, key identifiers and synonyms

Rizatriptan benzoate is a member of tryptamines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
benzoic acid, N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
CAS number
145202-66-0 CAS number cross-checked
EC number
604-465-6
Molecular formula
C22H25N5O2
UNII
WR978S7QHH
MDL number
MFCD00866224
InChIKey
JPRXYLQNJJVCMZ-UHFFFAOYSA-N
InChI
InChI=1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)
SMILES (canonical and isomeric)
CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3.C1=CC=C(C=C1)C(=O)O

Synonyms

  • Maxalt-MLT
  • Rizafilm
  • 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, monobenzoate
  • Symbravo component rizatriptan benzoate
  • 3-(2-(Dimethylamino)ethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)indole monobenzoate
  • 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)indole monobenzoate
  • Rizatriptan Benzoate ODT
  • 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1)
  • Maxalt
  • Rizatriptan (benzoate)
  • MK 462
  • N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate
  • 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethan-1-amine benzoate
  • benzoic acid, N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
  • Rizatriptanbenzoate
  • MK 0462
  • rizatrimptan benzoate
  • rizatriptane benzoate
  • rizatriptan, benzoate
  • Rizatriptan benzoate CRS
  • N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
  • Rizatriptan Benzoate (Maxalt)
  • Rizatriptan benzoate (JAN/USP)
  • Rizatriptan (benzoate) (Standard)
  • Rizatriptan for system suitability CRS

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
391.48 g/molcalc.
Exact mass
391.2008 Dacalc.
LogP (octanol/water)
3.3calc.
Topological polar surface area
87.04 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ncn(Cc2ccc3[nH]ccc3c2)n1

c1ncn(Cc2ccc3[nH]ccc3c2)n1

3 rings, 15 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
  • H336May cause drowsiness or dizziness.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Rizatriptan benzoate suppliers

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Where suppliers are based

90 suppliers in 15 countries

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Rizatriptan benzoate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacology

Rizatriptan Benzoate is the benzoate salt form of rizatriptan, a member of the triptan class agents with anti-migraine property. Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries, and to 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Rizatriptan benzoate may also relief migraine headaches by inhibition of pro-inflammatory neuropeptide release.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rizatriptan benzoate is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rizatriptan benzoate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rizatriptan benzoate, based on the data on this page

What is Rizatriptan benzoate?

Rizatriptan benzoate is a member of tryptamines.

What is the CAS number of Rizatriptan benzoate?

The CAS registry number of Rizatriptan benzoate is 145202-66-0.

What is the molecular formula and weight of Rizatriptan benzoate?

The molecular formula of Rizatriptan benzoate is C22H25N5O2 and its molar mass is 391.48 g/mol.

Is Rizatriptan benzoate hazardous?

Rizatriptan benzoate carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes serious eye irritation, may cause drowsiness or dizziness. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Rizatriptan benzoate?

Rizatriptan benzoate is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rizatriptan benzoate?

CompoundList lists 90 suppliers of Rizatriptan benzoate in China, India, United States, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Rizatriptan benzoate in India?

22 suppliers in India list Rizatriptan benzoate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Rizatriptan benzoate?

Suppliers quote Rizatriptan benzoate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rizatriptan benzoate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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