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Analgesics and anti-inflammatories

Rizatriptan

Also known as Risatriptan, MK 462 free base, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine

CAS 144034-80-0Formula C15H19N5Molar mass 269.35 g/molEC 812-626-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 73 suppliers listed Drug substance
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Rizatriptan chemical structure, C15H19N5, CAS 144034-80-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
144034-80-0
Formula
C15H19N5
Molar mass
269.35 g/mol
EC number
812-626-9
HS code
293399
Category
Analgesics and anti-inflammatories

What is Rizatriptan?

Plain description, key identifiers and synonyms

Rizatriptan is a member of tryptamines. It has a role as an anti-inflammatory drug, a serotonergic agonist and a vasoconstrictor agent. It is functionally related to a N,N-dimethyltryptamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
CAS number
144034-80-0 CAS number cross-checkedOther or deprecated CAS: 145202-66-0
EC number
812-626-9
Molecular formula
C15H19N5
UNII
51086HBW8G
MDL number
MFCD03840591
InChIKey
ULFRLSNUDGIQQP-UHFFFAOYSA-N
InChI
InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3

Synonyms

  • Risatriptan
  • MK 462 free base
  • N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
  • rizatriptanum
  • 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
  • N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
  • MK-462 FREE BASE
  • N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine
  • Dimethyl({2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethyl})amine
  • N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)-ethanamine
  • N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)ethanamine
  • dimethyl((2-(5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)ethyl))amine
  • N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indole-3-yl)ethylamine
  • 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
  • Rizatriptan (INN)
  • N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
  • Rizatriptan benzoat
  • Rizatriptan - API Standards
  • dimethyl(2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indol-3-yl}ethyl)amine
  • Dimethyl-[2-(5-[1,2,4]triazol-1-ylmethyl-1H-indol-3-yl)-ethyl]-amine
  • N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl] ethylamine
  • N,N-Dimethyl-2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indol-3-yl}ethan-1-amine
  • 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
269.35 g/molcalc.
Exact mass
269.164 Dacalc.
LogP (octanol/water)
1.91calc.
Topological polar surface area
49.74 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ncn(Cc2ccc3[nH]ccc3c2)n1

c1ncn(Cc2ccc3[nH]ccc3c2)n1

3 rings, 15 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H319Causes serious eye irritation.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P337 + P317If eye irritation persists: Get medical help.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Rizatriptan suppliers

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All 73 suppliers
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Where suppliers are based

73 suppliers in 15 countries

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Rizatriptan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Serotonin Receptor Agonists

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • cardiovascular drug
  • neurotransmitter agent
  • pharmaceutical
  • serotonergic agonist
  • serotonergic drug
  • vasoconstrictor agent

Pharmacology

Rizatriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. The mechanism of action of rizatriptan is as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rizatriptan is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rizatriptan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rizatriptan, based on the data on this page

What is Rizatriptan?

Rizatriptan is a member of tryptamines. It has a role as an anti-inflammatory drug, a serotonergic agonist and a vasoconstrictor agent. It is functionally related to a N,N-dimethyltryptamine.

What is the CAS number of Rizatriptan?

The CAS registry number of Rizatriptan is 144034-80-0. Other or deprecated CAS numbers: 145202-66-0.

What is the molecular formula and weight of Rizatriptan?

The molecular formula of Rizatriptan is C15H19N5 and its molar mass is 269.35 g/mol.

What is Rizatriptan used for?

Known uses and roles of Rizatriptan include anti-inflammatories in pharmaceuticals, cns agents in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, cardiovascular drug and 6 more.

Is Rizatriptan hazardous?

Rizatriptan carries the GHS signal word "Danger". Main hazards: causes serious eye irritation, may cause drowsiness or dizziness, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Rizatriptan?

Rizatriptan is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rizatriptan?

CompoundList lists 73 suppliers of Rizatriptan in China, United States, India, Spain and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Rizatriptan in India?

8 suppliers in India list Rizatriptan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Rizatriptan?

Suppliers quote Rizatriptan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rizatriptan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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