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Screening compounds

Ro 4929097

Also known as Rg 4733, Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pentafluoropropyl)-, 2,2-dimethyl-N-((10S)-9-oxo-8-azatricyclo(9.4.0.02,7)pentadeca-1(15),2,4,6,11,13-hexaen-10-yl)-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide

CAS 847925-91-1Formula C22H20F5N3O3Molar mass 469.41 g/mol
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Ro 4929097 chemical structure, C22H20F5N3O3, CAS 847925-91-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
847925-91-1
Formula
C22H20F5N3O3
Molar mass
469.41 g/mol
HS code
293379
Category
Screening compounds

What is Ro 4929097?

Plain description, key identifiers and synonyms

RO4929097 is a member of the class of dibenzoazepines that is the amide formed from formal condensation of the carboxy group of 2,2-dimethyl-3-oxo-3-[(2,2,3,3,3-pentafluoropropyl)amino]propanoic acid with the amino group of (7S)-7-amino-5,7-dihydrodibenzo[b,d]azepin-6-one. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a lactam, a dicarboxylic acid diamide, an organofluorine compound and a dibenzoazepine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
CAS number
847925-91-1 CAS number cross-checked
Molecular formula
C22H20F5N3O3
UNII
KK8645V7LE
MDL number
MFCD18384976
InChIKey
OJPLJFIFUQPSJR-INIZCTEOSA-N
InChI
InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
Canonical SMILES
CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)NC1C(=O)Nc2ccccc2-c2ccccc21
Isomeric SMILES
CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

Synonyms

  • Rg 4733
  • Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pentafluoropropyl)-
  • 2,2-dimethyl-N-((10S)-9-oxo-8-azatricyclo(9.4.0.02,7)pentadeca-1(15),2,4,6,11,13-hexaen-10-yl)-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • 2,2-dimethyl-N-[(10S)-9-oxo-8-azatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-10-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • 2,2-dimethyl-N'-((10S)-9-oxo-8-azatricyclo(9.4.0.0^(2,7))pentadeca-1(15),2,4,6,11,13-hexaen-10-yl)-N-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • (S)-2,2-dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide
  • N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • Propanediamide, n1-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-n3-(2,2,3,3,3-pentafluoropropyl)-
  • Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-
  • RO4929097?
  • 2,2-dimethyl-N'-[(10S)-9-oxo-8-azatricyclo[9.4.0.0(2),?]pentadeca-1(11),2,4,6,12,14-hexaen-10-yl]-N-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • 2,2-dimethyl-N(1)-[(7S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N(3)-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide
  • 2,2-dimethyl-N-[(10S)-9-oxo-8-azatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-10-yl]-
  • 2,2-Dimethyl-N~1~-[(7S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N~3~-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • N-((7S)-6,7-Dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pentafluoropropyl)-propanediamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
469.41 g/molcalc.
Exact mass
469.1425 Dacalc.
LogP (octanol/water)
3.8calc.
Topological polar surface area
87.3 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Cc2ccccc2-c2ccccc2N1

O=C1Cc2ccccc2-c2ccccc2N1

3 rings, 16 atoms, the 8-Azatricyclo[9.4.0.0,2,7]pentadeca-1(15),2,4,6,11,13-hexaen-9-one ring system.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ro 4929097 suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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Ro 4929097 price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Gamma-Secretase Inhibitor RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ro 4929097 is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ro 4929097 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ro 4929097, based on the data on this page

What is Ro 4929097?

RO4929097 is a member of the class of dibenzoazepines that is the amide formed from formal condensation of the carboxy group of 2,2-dimethyl-3-oxo-3-[(2,2,3,3,3-pentafluoropropyl)amino]propanoic acid with the amino group of (7S)-7-amino-5,7-dihydrodibenzo[b,d]azepin-6-one.

What is the CAS number of Ro 4929097?

The CAS registry number of Ro 4929097 is 847925-91-1.

What is the molecular formula and weight of Ro 4929097?

The molecular formula of Ro 4929097 is C22H20F5N3O3 and its molar mass is 469.41 g/mol.

What is Ro 4929097 used for?

Known uses and roles of Ro 4929097 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, enzyme inhibitor and pharmaceutical.

Is Ro 4929097 hazardous?

No GHS hazard classification for Ro 4929097 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ro 4929097?

Ro 4929097 is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ro 4929097?

CompoundList lists 3 suppliers of Ro 4929097 in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ro 4929097?

Suppliers quote Ro 4929097 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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