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Pharmaceuticals and APIs

Salmeterol

Also known as 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol, Salmeterolum, GR 33343X

CAS 89365-50-4Formula C25H37NO4Molar mass 415.57 g/molEC 618-267-2
GHS signal word: Warning. Pictograms: Harmful or irritant 76 suppliers listed Drug substance
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Salmeterol chemical structure, C25H37NO4, CAS 89365-50-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
89365-50-4
Formula
C25H37NO4
Molar mass
415.57 g/mol
Melting point
75.7 to 76.5
HS code
292250
Category
Pharmaceuticals and APIs

What is Salmeterol?

Plain description, key identifiers and synonyms

2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol is a phenol having a hydroxymethyl group at C-2 and a 1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl group at C-4, derivative of phenylethanolamine. It is a primary alcohol, an ether, a member of phenols, a secondary alcohol and a secondary amino compound. It is functionally related to a phenylethanolamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
CAS number
89365-50-4 CAS number cross-checked
EC number
618-267-2
Molecular formula
C25H37NO4
UNII
2I4BC502BT
MDL number
MFCD00867037
InChIKey
GIIZNNXWQWCKIB-UHFFFAOYSA-N
InChI
InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
SMILES (canonical and isomeric)
C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O

Synonyms

  • 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
  • Salmeterolum
  • GR 33343X
  • Salmaterol
  • GR 33343 X
  • 4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol
  • 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol
  • Neovent
  • Soltel
  • 2-(hydroxymethyl)-4-(1-hydroxy-2-(6-(4-phenylbutoxy)hexylamino)ethyl)phenol
  • Arial
  • Beglan
  • Salmetedur
  • salmeterolo
  • Aeromax
  • Astmerole
  • 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol
  • 4-(1-hydroxy-2-(6-(4-phenylbutoxy)hexylamino)ethyl)-2-(hydroxymethyl)phenol
  • Salmeterol (USAN/INN)
  • Salmeterol?
  • Salmeterolxinafoate
  • (+-)-4-Hydroxy-alpha'-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol
  • (+-)-4-Hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedimethanol
  • Sdccgsbi-0633788.p001
  • 1,3-Benzenedimethanol, 4-hydroxy-alpha1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-
Show all 27 synonyms
  • 1,3-Benzenedimethanol, 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)-
  • 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
75.7 to 76.5exp.
Vapour pressure
1.9 × 10⁻¹⁵ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
415.57 g/molcalc.
Exact mass
415.2723 Dacalc.
LogP (octanol/water)
4.11calc.
Topological polar surface area
81.95 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
16calc.
Heavy atoms
30calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCCCOCCCCCCNCCc2ccccc2)cc1

c1ccc(CCCCOCCCCCCNCCc2ccccc2)cc1

2 rings, 26 atoms.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (17)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Salmeterol suppliers

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All 76 suppliers
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Where suppliers are based

76 suppliers in 14 countries

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Salmeterol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anti-asthmatic (Xinafoate salt).

Bronchodilator.

Salmeterol ... (is) indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease, including bronchitis and pulmonary emphysema. ... (Included in US product labeling).

Use classes: Pharmaceuticals.

Roles

  • adrenergic agent
  • adrenergic agonist
  • anti-asthmatic agent
  • beta-adrenergic agonist
  • beta-adrenergic drug
  • bronchodilator agent
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Salmeterol is a beta2-Adrenergic Agonist. The mechanism of action of salmeterol is as an Adrenergic beta2-Agonist.

How it is made

Preparation: I.F. Skidmore et al., DE 3414752, eidem US 4992474 (1984, 1991 both to Glaxo)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Salmeterol is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Salmeterol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Salmeterol, based on the data on this page

What is Salmeterol?

2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol is a phenol having a hydroxymethyl group at C-2 and a 1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl group at C-4, derivative of phenylethanolamine.

What is the CAS number of Salmeterol?

The CAS registry number of Salmeterol is 89365-50-4.

What is the molecular formula and weight of Salmeterol?

The molecular formula of Salmeterol is C25H37NO4 and its molar mass is 415.57 g/mol.

What is Salmeterol used for?

Anti-asthmatic (Xinafoate salt). Bronchodilator. Salmeterol ... (is) indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease, including bronchitis and pulmonary emphysema. ... (Included in US product labeling). Use classes: Pharmaceuticals.

Is Salmeterol hazardous?

Salmeterol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Salmeterol?

Salmeterol is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Salmeterol?

CompoundList lists 76 suppliers of Salmeterol in China, United States, Germany, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Salmeterol in India?

4 suppliers in India list Salmeterol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Salmeterol?

Suppliers quote Salmeterol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Salmeterol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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