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Hormones and steroids

Semaglutide

Also known as Rybelsus, Ozempic, Wegovy

CAS 910463-68-2Formula C187H291N45O59Molar mass 4,113.64 g/molEC 691-729-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard Controlled, licensed buyers only Drug substance
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Semaglutide chemical structure, C187H291N45O59, CAS 910463-68-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
910463-68-2
Formula
C187H291N45O59
Molar mass
4,113.64 g/mol
EC number
691-729-9
HS code
293719
Category
Hormones and steroids

What is Semaglutide?

Plain description, key identifiers and synonyms

Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as an antidepressant, a hypoglycemic agent, an appetite depressant, a neuroprotective agent, a glucagon-like peptide-1 receptor agonist and an anti-obesity agent. It is a polypeptide and a lipopeptide.

Semaglutide is a medication used to treat type 2 diabetes and obesity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxoprop...
CAS number
910463-68-2 CAS number cross-checked
EC number
691-729-9
Molecular formula
C187H291N45O59
UNII
53AXN4NNHX
InChIKey
DLSWIYLPEUIQAV-CCUURXOWSA-N
InChI
InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1
Canonical SMILES
CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC6=CN=CN6)N

Synonyms

  • Rybelsus
  • Ozempic
  • Wegovy
  • NN 9535
  • NNC 0113-0217
  • semaglutida
  • semaglutidum
  • Oral Semaglutide
  • Kayshild
  • Semaglutide impurity
  • Semaglutide free base
  • Semaglutide(sodium salt)?
  • Rybelsus (oral semaglutide)
  • Ozempic (injectable semaglutide)
  • NNC0480 0389
  • Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
4,113.64 g/molcalc.
Exact mass
4,111.1154 Dacalc.
LogP (octanol/water)
-11.63calc.
Topological polar surface area
1,646 Ųcalc.
Hydrogen bond donors
57calc.
Hydrogen bond acceptors
56calc.
Rotatable bonds
149calc.
Heavy atoms
291calc.
Rings
6calc.
Aromatic rings
6calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
30calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302 + H312 + H332Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H360DMay damage the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Semaglutide suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Prescription medicine ingredient

Semaglutide is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: Prescription only peptide

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for Semaglutide with their licence. Our compliance team reviews it before suppliers see it.

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Semaglutide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • G-protein-coupled receptor agonist
  • agonist
  • anti-asthmatic agent
  • anti-obesity agent
  • antidepressant
  • antidyskinesia agent
  • antiparkinson drug
  • appetite depressant
  • appetite regulator
  • cardiovascular drug
  • central nervous system drug
  • glucagon-like peptide-1 receptor agonist
  • hypoglycemic agent
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • psychotropic drug

Pharmacology

Semaglutide is a GLP-1 Receptor Agonist. The mechanism of action of semaglutide is as a Glucagon-like Peptide-1 (GLP-1) Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Prescription medicine ingredient

Semaglutide is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: Prescription only peptide

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels
  • Prescription medicine active ingredient

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Semaglutide is traded under.

HS 2937.19Indicative HS code

Polypeptide hormones, protein hormones and glycoprotein hormones, their derivatives and…

World exports in 2024
$31.5B
+59.6% vs 2023, imports $32.6B
2019 to 2024
Top exporters
  1. Ireland57.3%
  2. United States29.0%
  3. Denmark6.3%
Top importers
  1. United States50.4%
  2. Italy28.1%
  3. Germany7.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Semaglutide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Semaglutide, based on the data on this page

What is Semaglutide?

Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes.

What is the CAS number of Semaglutide?

The CAS registry number of Semaglutide is 910463-68-2.

What is the molecular formula and weight of Semaglutide?

The molecular formula of Semaglutide is C187H291N45O59 and its molar mass is 4,113.64 g/mol.

What is Semaglutide used for?

Known uses and roles of Semaglutide include hormones and steroids in pharmaceuticals, g-protein-coupled receptor agonist, agonist, anti-asthmatic agent, anti-obesity agent and 13 more.

Is Semaglutide hazardous?

Semaglutide carries the GHS signal word "Danger". Main hazards: harmful if swallowed. harmful in contact with skin. harmful if inhaled, harmful if swallowed, harmful in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Semaglutide?

Semaglutide is usually classified under HS code 293719 (Polypeptide hormones, protein hormones and glycoprotein hormones, their derivatives and…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Semaglutide on CompoundList?

Semaglutide is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Semaglutide

Request as a licensed buyer

Upload your licence with the request. Our compliance team reviews it before the documented suppliers see it.
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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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