CompoundList
Sign in
Pharmaceuticals and APIs

Setmelanotide

Also known as Setmelanotida, Setmelanotidum, Setmelanotide (RM-493)

CAS 920014-72-8Formula C49H68N18O9S2Molar mass 1,117.33 g/mol
5 suppliers listed Drug substance
Get quotes Compare 5 suppliers
Setmelanotide chemical structure, C49H68N18O9S2, CAS 920014-72-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
920014-72-8
Formula
C49H68N18O9S2
Molar mass
1,117.33 g/mol
HS code
293499
Category
Pharmaceuticals and APIs

What is Setmelanotide?

Plain description, key identifiers and synonyms

Setmelanotide is a Melanocortin 4 Receptor Agonist. The mechanism of action of setmelanotide is as a Melanocortin 4 Receptor Agonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide
CAS number
920014-72-8 CAS number cross-checked
Molecular formula
C49H68N18O9S2
UNII
N7T15V1FUY
InChIKey
HDHDTKMUACZDAA-PHNIDTBTSA-N
InChI
InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1
Canonical SMILES
CC(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(C(N)=O)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN=C(N)N)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2cnc[nH]2)NC(=O)C(C)NC1=O
Isomeric SMILES
C[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5

Synonyms

  • Setmelanotida
  • Setmelanotidum
  • Setmelanotide (RM-493)
  • L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2->8)-disulfide
  • RM-493, BIM-22493, IRC-022493
  • N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2-8)-disulfide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,117.33 g/molcalc.
Exact mass
1,116.4858 Dacalc.
LogP (octanol/water)
-3.18calc.
Topological polar surface area
449.2 Ųcalc.
Hydrogen bond donors
15calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
18calc.
Heavy atoms
78calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCSSCCNC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)C(Cc2cnc[nH]2)NC(=O)CN1

O=C1CCSSCCNC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)C(Cc2cnc[nH]2)NC(=O)CN1

5 rings, 52 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Setmelanotide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
5 of 5 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 4 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Setmelanotide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-obesity agent

Pharmacology

Setmelanotide is a melanocortin 4 receptor agonist that is used for chronic weight management for adults and children with rare genetic forms obesity due to gene defects in the melanocortin pathway. Setmelanotide therapy has not been associated serum aminotransferase or bilirubin elevations or to instances of clinically apparent liver injury.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Setmelanotide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Setmelanotide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Setmelanotide, based on the data on this page

What is Setmelanotide?

Setmelanotide is a Melanocortin 4 Receptor Agonist. The mechanism of action of setmelanotide is as a Melanocortin 4 Receptor Agonist.

What is the CAS number of Setmelanotide?

The CAS registry number of Setmelanotide is 920014-72-8.

What is the molecular formula and weight of Setmelanotide?

The molecular formula of Setmelanotide is C49H68N18O9S2 and its molar mass is 1,117.33 g/mol.

What is Setmelanotide used for?

Known uses and roles of Setmelanotide include anti-obesity agent.

Is Setmelanotide hazardous?

No GHS hazard classification for Setmelanotide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Setmelanotide?

Setmelanotide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Setmelanotide?

CompoundList lists 5 suppliers of Setmelanotide in China, Spain, Japan and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Setmelanotide?

Suppliers quote Setmelanotide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Setmelanotide

Get quotes for Setmelanotide

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Setmelanotide
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Setmelanotide with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/setmelanotide-920014-72-8" title="Setmelanotide structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Pharmaceuticals and APIs or HS code 293499

5 suppliers
Free quotes, contact stays private
Get quotes