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Antibiotics and anti-infectives

Sofosbuvir

Also known as Sovaldi, PSI 7977, GS 7977

CAS 1190307-88-0Formula C22H29FN3O9PMolar mass 529.46 g/molEC 695-717-4
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 120 suppliers listed Drug substance
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Sofosbuvir chemical structure, C22H29FN3O9P, CAS 1190307-88-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1190307-88-0
Formula
C22H29FN3O9P
Appearance
White to off-white crystalline solid
Solubility
Slightly soluble in water
HS code
293499
Category
Antibiotics and anti-infectives
Illustrative photo, colourless crystals in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Sofosbuvir?

Plain description, key identifiers and synonyms

Sofosbuvir is a nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. It has a role as an antiviral drug, a prodrug and a hepatitis C protease inhibitor. It is a phosphoramidate ester, an isopropyl ester, an organofluorine compound, a nucleotide conjugate and a L-alanyl ester. It is functionally related to a uridine 5'-monophosphate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
CAS number
1190307-88-0 CAS number cross-checked
EC number
695-717-4
Molecular formula
C22H29FN3O9P
UNII
WJ6CA3ZU8B
MDL number
MFCD26523124
InChIKey
TTZHDVOVKQGIBA-IQWMDFIBSA-N
InChI
InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
Canonical SMILES
CC(C)OC(=O)C(C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)C(C)(F)C1O)Oc1ccccc1
Isomeric SMILES
C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Synonyms

  • Sovaldi
  • PSI 7977
  • GS 7977
  • Vosevi component sofosbuvir
  • Epclusa component sofosbuvir
  • Harvoni component sofosbuvir
  • 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
  • L-Alanine, N-((P(S),2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl)-, 1-methylethyl ester
  • propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
  • sofosbuvirum
  • Sovaldi Access
  • L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
  • 7977, PSI
  • Psi-7977, gs-7977
  • propan-2-yl (2S)-2-((((2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl)methoxy-phenoxyphosphoryl)amino)propanoate
  • Sofosbuvir (GS-7977)
  • Hepcinat
  • Hepcvir
  • Resof
  • SoviHep
  • Sovaldi (TN)
  • Sofosbuvir (Standard)
  • Sofosbuvir (JAN/USAN/INN)
  • Sofosbuvir - Bio-X trade mark
  • SofosbuvirPSI7977GS-7977
Show all 28 synonyms
  • SofosbuvirPSI7977GS-7977?
  • GI 7977
  • Sofosbuvir (PSI-7977, GS-7977)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white crystalline solidexp.
Solubility
Slightly soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
529.46 g/molcalc.
Exact mass
529.1625 Dacalc.
LogP (octanol/water)
1.66calc.
Topological polar surface area
158.2 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
10calc.
Heavy atoms
36calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccn(C2CCC(CO[PH](=O)Oc3ccccc3)O2)c(=O)[nH]1

O=c1ccn(C2CCC(CO[PH](=O)Oc3ccccc3)O2)c(=O)[nH]1

3 rings, 24 atoms.

90 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sofosbuvir suppliers

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Where suppliers are based

120 suppliers in 18 countries

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Sofosbuvir price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antiviral.

Industries and functions

Pharmacological actions

  • Antiviral Agents

Roles

  • anti-HBV agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiviral agent
  • antiviral drug
  • enzyme inhibitor
  • hepatitis C protease inhibitor
  • pharmaceutical
  • pro-agent
  • prodrug
  • protease inhibitor

Pharmacology

Sofosbuvir is a Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor. The mechanism of action of sofosbuvir is as a RNA Replicase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sofosbuvir is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Sofosbuvir is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sofosbuvir, based on the data on this page

What is Sofosbuvir?

Sofosbuvir is a nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. It has a role as an antiviral drug, a prodrug and a hepatitis C protease inhibitor.

What is the CAS number of Sofosbuvir?

The CAS registry number of Sofosbuvir is 1190307-88-0.

What is the molecular formula and weight of Sofosbuvir?

The molecular formula of Sofosbuvir is C22H29FN3O9P and its molar mass is 529.46 g/mol.

What is Sofosbuvir used for?

Antiviral.

Is Sofosbuvir hazardous?

Sofosbuvir carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes damage to organs through prolonged or repeated exposure, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sofosbuvir?

Sofosbuvir is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sofosbuvir?

CompoundList lists 120 suppliers of Sofosbuvir in China, United States, India, Pakistan and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sofosbuvir in India?

19 suppliers in India list Sofosbuvir on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sofosbuvir?

Suppliers quote Sofosbuvir on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sofosbuvir

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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