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Peptides

Sovateltide

Also known as Sovatelitide, Succinyl-(glu(9),ala(11,15))-endothelin-1 (8-21), Succinyl-(glutamyl(9)-alanyl(11,15))-endothelin-1 (8-21)

CAS 142569-99-1Formula C86H117N17O27Molar mass 1,820.97 g/molEC 686-380-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 3 suppliers listed
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Sovateltide chemical structure, C86H117N17O27, CAS 142569-99-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
142569-99-1
Formula
C86H117N17O27
Molar mass
1,820.97 g/mol
EC number
686-380-4
HS code
293329
Category
Peptides

What is Sovateltide?

Plain description, key identifiers and synonyms

Sovateltide is a highly selective peptide agonist of the endothelin-B receptor. Sovateltide binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle. This agent may induce a transient, selective increase in blood flow to a tumor, which may result in an increase in the delivery of anticancer agents to the tumor and, so, an increase in anticancer agent efficacy.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4S)-4-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-(3-carboxypropanoylamino)propanoyl]amino]butanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS number
142569-99-1 CAS number cross-checked
EC number
686-380-4
Molecular formula
C86H117N17O27
UNII
11X778QIZS
InChIKey
DXPHNGAMYPPTBJ-TZMIJSMNSA-N
InChI
InChI=1S/C86H117N17O27/c1-11-44(7)71(84(127)100-63(86(129)130)35-50-39-88-54-21-17-16-20-53(50)54)103-85(128)72(45(8)12-2)102-82(125)62(38-69(114)115)98-78(121)57(32-42(3)4)96-80(123)60(36-51-40-87-41-89-51)95-73(116)46(9)91-77(120)58(33-48-18-14-13-15-19-48)97-79(122)59(34-49-22-24-52(104)25-23-49)99-83(126)70(43(5)6)101-74(117)47(10)90-75(118)55(26-29-65(106)107)93-76(119)56(27-30-66(108)109)94-81(124)61(37-68(112)113)92-64(105)28-31-67(110)111/h13-25,39-47,55-63,70-72,88,104H,11-12,26-38H2,1-10H3,(H,87,89)(H,90,118)(H,91,120)(H,92,105)(H,93,119)(H,94,124)(H,95,116)(H,96,123)(H,97,122)(H,98,121)(H,99,126)(H,100,127)(H,101,117)(H,102,125)(H,103,128)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H,129,130)/t44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,70-,71-,72-/m0/s1
Canonical SMILES
CCC(C)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(C)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)C(C)CC
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O

Synonyms

  • Sovatelitide
  • Succinyl-(glu(9),ala(11,15))-endothelin-1 (8-21)
  • Succinyl-(glutamyl(9)-alanyl(11,15))-endothelin-1 (8-21)
  • Endothelin B Receptor Agonist SPI-1620
  • Spi-1620
  • Irl 1620
  • Sovatelitide (USAN)
  • Endothelin-1 (8-21), succinyl-(glu(9),ala(11,15))-
  • WHO 11139
  • [125I]IRL1620
  • [125I]-IRL1620
  • [125I]IRL 1620
  • Suc-[Glu9,Ala11,15]-endothelin-1(8-21)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,820.97 g/molcalc.
Exact mass
1,819.8305 Dacalc.
LogP (octanol/water)
-0.88calc.
Topological polar surface area
695.9 Ųcalc.
Hydrogen bond donors
23calc.
Hydrogen bond acceptors
22calc.
Rotatable bonds
56calc.
Heavy atoms
130calc.
Rings
5calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
16calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNC(=O)CNC(=O)CNC(=O)CNC(=O)C(Cc1c[nH]cn1)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)CCc1ccccc1)NCCc1c[nH]c2ccccc12

O=C(CNC(=O)CNC(=O)CNC(=O)CNC(=O)C(Cc1c[nH]cn1)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)CCc1ccccc1)NCCc1c[nH]c2ccccc12

5 rings, 63 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H300 + H330Fatal if swallowed. Fatal if inhaled.
  • H300Fatal if swallowed.
  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H330Fatal if inhaled.
  • H332Harmful if inhaled.
Precautionary statements (20)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sovateltide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 3 countries

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Sovateltide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sovateltide is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sovateltide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sovateltide, based on the data on this page

What is Sovateltide?

Sovateltide is a highly selective peptide agonist of the endothelin-B receptor. Sovateltide binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle.

What is the CAS number of Sovateltide?

The CAS registry number of Sovateltide is 142569-99-1.

What is the molecular formula and weight of Sovateltide?

The molecular formula of Sovateltide is C86H117N17O27 and its molar mass is 1,820.97 g/mol.

What is Sovateltide used for?

Known uses and roles of Sovateltide include antineoplastic agent and pharmaceutical.

Is Sovateltide hazardous?

Sovateltide carries the GHS signal word "Danger". Main hazards: fatal if swallowed. fatal if inhaled, fatal if swallowed, harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sovateltide?

Sovateltide is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sovateltide?

CompoundList lists 3 suppliers of Sovateltide in China, United Kingdom and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Sovateltide?

Suppliers quote Sovateltide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sovateltide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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