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Cardiovascular and metabolic drugs

Sparsentan

Also known as Filspari, esparsentan, sparsentanum

CAS 254740-64-2Formula C32H40N4O5SMolar mass 592.76 g/molEC 839-064-7
GHS signal word: Warning. Pictograms: Serious health hazard 22 suppliers listed Drug substance
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Sparsentan chemical structure, C32H40N4O5S, CAS 254740-64-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
254740-64-2
Formula
C32H40N4O5S
Molar mass
592.76 g/mol
EC number
839-064-7
HS code
293590
Category
Cardiovascular and metabolic drugs

What is Sparsentan?

Plain description, key identifiers and synonyms

Sparsentan is a biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression. It has a role as an antihypertensive agent, an endothelin A receptor antagonist, an angiotensin receptor antagonist and a nephroprotective agent. It is a member of biphenyls, a sulfonamide, an azaspiro compound, a member of isoxazoles and a benzyl ether.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
CAS number
254740-64-2
EC number
839-064-7
Molecular formula
C32H40N4O5S
UNII
9242RO5URM
MDL number
MFCD16628036
InChIKey
WRFHGDPIDHPWIQ-UHFFFAOYSA-N
InChI
InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
SMILES (canonical and isomeric)
CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC

Synonyms

  • Filspari
  • esparsentan
  • sparsentanum
  • (1,1'-Biphenyl)-2-sulfonamide, 4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-
  • 4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)biphenyl-2-sulfonamide
  • 4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)-(1,1'-biphenyl)-2-sulfonamide
  • Sparsentan (RE-021)
  • retrophin
  • 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
  • 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide
  • RE 201
  • DARA
  • PS 33540
  • 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)[1,1'-biphenyl]-2-sulfonamide
  • Spashentan
  • Filspari (TN)
  • compound 7
  • Sparsentan(PS433540)?
  • Sparsentan (JAN/USAN/INN)
  • DARA-a (Dual Acting Receptor Antagonist of angiotension and endothelin receptors)
  • Sparsentan (PS-433540, RE-021)
  • PS 433540
  • 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide
  • 4''''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2''''-ethoxymethyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-amide
  • 4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2''-ethoxymethyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-amide
Show all 29 synonyms
  • 4'-((2-Butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyi)-N-(4,5- dimethylisoxazol-3-yl)-2'-(ethoxymethyl)biphenyl-2-sulfonamide
  • 4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)-2-biphenylsulfonamide
  • 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(e
  • 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)[biphenyl]-2-sulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
592.76 g/molcalc.
Exact mass
592.2719 Dacalc.
LogP (octanol/water)
6.54calc.
Topological polar surface area
114.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
12calc.
Heavy atoms
42calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1N(Cc2ccc(-c3ccccc3S(=O)(=O)Nc3ccon3)cc2)C=NC12CCCC2

O=C1N(Cc2ccc(-c3ccccc3S(=O)(=O)Nc3ccon3)cc2)C=NC12CCCC2

5 rings, 32 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (6)
  • P203Obtain, read and follow all safety instructions before use.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sparsentan suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 22 suppliers
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Where suppliers are based

22 suppliers in 7 countries

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Sparsentan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

  • angiotensin receptor antagonist
  • antagonist
  • antihypertensive agent
  • cardiovascular drug
  • endothelin A receptor antagonist
  • endothelin receptor antagonist
  • hormone antagonist
  • hormone receptor modulator
  • nephroprotective agent
  • pharmaceutical
  • protective agent
  • receptor modulator

Pharmacology

Sparsentan is an Endothelin Receptor Antagonist and Angiotensin 2 Receptor Blocker. The mechanism of action of sparsentan is as an Endothelin Receptor Antagonist, and Angiotensin 2 Type 1 Receptor Antagonist, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer, and P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sparsentan is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sparsentan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sparsentan, based on the data on this page

What is Sparsentan?

Sparsentan is a biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively.

What is the CAS number of Sparsentan?

The CAS registry number of Sparsentan is 254740-64-2.

What is the molecular formula and weight of Sparsentan?

The molecular formula of Sparsentan is C32H40N4O5S and its molar mass is 592.76 g/mol.

What is Sparsentan used for?

Known uses and roles of Sparsentan include antihypertensives in pharmaceuticals, angiotensin receptor antagonist, antagonist, antihypertensive agent, cardiovascular drug and 8 more.

Is Sparsentan hazardous?

Sparsentan carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child, suspected of damaging the unborn child, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sparsentan?

Sparsentan is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sparsentan?

CompoundList lists 22 suppliers of Sparsentan in China, India, United States, Canada and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sparsentan in India?

4 suppliers in India list Sparsentan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sparsentan?

Suppliers quote Sparsentan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sparsentan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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