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Cardiovascular and metabolic drugs

Spironolactone

Also known as Aldactone, Verospirone, Spirolactone

CAS 52-01-7Formula C24H32O4SMolar mass 416.58 g/molEC 200-133-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 108 suppliers listed Drug substance
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Spironolactone chemical structure, C24H32O4S, CAS 52-01-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from methanol
Melting point
134 to 135
Boiling point
134 °C
Solubility
In water, 22 mg/L at 25 °C
HS code
293220
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Spironolactone?

Plain description, key identifiers and synonyms

Spironolactone is a steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. It has a role as a diuretic, an antihypertensive agent, a xenobiotic, an aldosterone antagonist and an environmental contaminant. It is a steroid lactone, an oxaspiro compound, a 3-oxo-Delta(4) steroid and a thioester.

Spironolactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
CAS number
52-01-7 CAS number cross-checked
EC number
200-133-6
Molecular formula
C24H32O4S
UNII
27O7W4T232
MDL number
MFCD00082250
INCI name
SPIRONOLACTONE
InChIKey
LXMSZDCAJNLERA-ZHYRCANASA-N
InChI
InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
Canonical SMILES
CC(=O)SC1CC2=CC(=O)CCC2(C)C2CCC3(C)C(CCC34CCC(=O)O4)C12
Isomeric SMILES
CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C

Synonyms

  • Aldactone
  • Verospirone
  • Spirolactone
  • Spiresis
  • Uractone
  • Xenalon
  • spironolattone
  • Espironolactona
  • Spironolactonum
  • Abbolactone
  • Diatensec
  • Laractone
  • SC 9420
  • Spironolactone ceva
  • Carospir
  • Spiretic
  • S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
  • Veroshpiron
  • 3-(3-Keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid lactone
  • 17alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7alpha-mercapto-3-oxo-, gamma-lactone, acetate
  • Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
  • Cardalis component spironolactone
  • 7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone
  • NovoSpiroton
  • Novo Spiroton
Show all 38 synonyms
  • Spirono Isis
  • von ct, spiro
  • (1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-6'-ene-5,5'-dione
  • Gx spironol
  • Spirospare 25
  • Spiroctan 25
  • Spiroctan 50
  • Ct, Spiro Von
  • Spirospare 100
  • (1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro(oxolane-2,14'-tetracyclo(8.7.0.0^(2,7).0^(11,15))heptadecan)-6'-ene-5,5'-dione
  • S-((7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro(2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthrene-17,2'-oxolane)-7-yl) ethanethioate
  • Spiroctan 100
  • 7alpha-Acetylsulfanyl-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methanolexp.
Odour
Mild mercaptan-like odorexp.
Melting point
134 to 135exp.
Boiling point
134 °Cexp.
Solubility
In water, 22 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
416.58 g/molcalc.
Exact mass
416.2021 Dacalc.
LogP (octanol/water)
4.85calc.
Topological polar surface area
60.44 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
29calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.79calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C(CCC4C3CCC43CCC(=O)O3)C2CC1

O=C1C=C2CCC3C(CCC4C3CCC43CCC(=O)O3)C2CC1

5 rings, 23 atoms.

36 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Spironolactone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 108 suppliers
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Where suppliers are based

108 suppliers in 24 countries

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Spironolactone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Diuretic.

Therapeutic category: Diuretic.

Therapeutic category (veterinary): Diuretic.

Veterinary medication:.

Use classes: Pharmaceuticals, Animal Drugs.

Industries and functions

Cosmetic ingredient, INCI name SPIRONOLACTONE(not reported)

Pharmacological actions

  • Diuretics
  • Mineralocorticoid Receptor Antagonists

Roles

  • aldosterone antagonist
  • antagonist
  • anti-arrhythmia drug
  • antifibrotic agent
  • antihypertensive agent
  • antimicrobial agent
  • antimineralocorticoid
  • antineoplastic agent
  • antirheumatic drug
  • antiviral agent
  • cardiovascular drug
  • diuretic
  • environmental contaminant
  • hepatoprotective agent
  • hormone antagonist
  • hormone receptor modulator
  • hypoglycemic agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • receptor modulator
  • renoprotective agent
  • xenobiotic

Functional uses

  • Pharmaceutical

Cosmetic functions

  • Not reported

Pharmacology

Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

How it is made

Us patent 3013012 (1961 to searle)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Spironolactone (INN), Ref no: 4, Annex ref: II/4
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Spironolactone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Spironolactone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Spironolactone, based on the data on this page

What is Spironolactone?

Spironolactone is a steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. It has a role as a diuretic, an antihypertensive agent, a xenobiotic, an aldosterone antagonist and an environmental contaminant.

What is the CAS number of Spironolactone?

The CAS registry number of Spironolactone is 52-01-7.

What is the molecular formula and weight of Spironolactone?

The molecular formula of Spironolactone is C24H32O4S and its molar mass is 416.58 g/mol.

What is Spironolactone used for?

Diuretic. Therapeutic category: Diuretic. Therapeutic category (veterinary): Diuretic. Veterinary medication:. Use classes: Pharmaceuticals, Animal Drugs.

Is Spironolactone hazardous?

Spironolactone carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Spironolactone?

Spironolactone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Spironolactone?

CompoundList lists 108 suppliers of Spironolactone in China, United States, India, Germany and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Spironolactone in India?

10 suppliers in India list Spironolactone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Spironolactone?

Suppliers quote Spironolactone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Spironolactone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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