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Analgesics and anti-inflammatories

Sufentanil

Also known as Sufentanyl, Chronogesic, Sufentanilum

CAS 56030-54-7Formula C22H30N2O2SMolar mass 386.56 g/molEC 641-081-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant Prohibited, not for trade Drug substance
Why it is not for trade
Sufentanil chemical structure, C22H30N2O2S, CAS 56030-54-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from petroleum ether
Melting point
96.6 °C
Solubility
46 mg/ml /Sufentanil citrate/
HS code
293491
Category
Analgesics and anti-inflammatories

What is Sufentanil?

Plain description, key identifiers and synonyms

Sufentanil is an anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. It has a role as an opioid analgesic, an intravenous anaesthetic, a mu-opioid receptor agonist and an anaesthesia adjuvant. It is an anilide, an ether, a member of piperidines and a member of thiophenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
CAS number
56030-54-7 CAS number cross-checked
EC number
641-081-8
Molecular formula
C22H30N2O2S
UNII
AFE2YW0IIZ
InChIKey
GGCSSNBKKAUURC-UHFFFAOYSA-N
InChI
InChI=1S/C22H30N2O2S/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20/h4-10,17H,3,11-16,18H2,1-2H3
SMILES (canonical and isomeric)
CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC

Synonyms

  • Sufentanyl
  • Chronogesic
  • Sufentanilum
  • Zalviso
  • Sufentanilo
  • N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide
  • N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide
  • Sulfentanil
  • Sulfentanyl
  • Propanamide, N-(4-(methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenyl-
  • N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]propionanilide
  • Propanamide, N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-
  • N-[4-(methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropanamide
  • SufentanilHameln
  • Sufentanil Hameln
  • N-(4-(methoxymethyl)-1-(2-(thiophen-2-yl)ethyl)piperidin-4-yl)-N-phenylpropanamide
  • N-[4-(Methoxymethyl)-1-{2-(2-thienyl)ethyl}-4-piperidinyl]-N-phenylpropanamide
  • N-{4-(Methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl}-N-phenylpropanamide
  • SufentanilRatiopharm
  • Citrate, Sufentanil
  • Curasan, Sufentanil
  • Sufentanil Ratiopharm
  • DEA No. 9740
  • N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
  • Sufentanil (USAN/INN)
Show all 29 synonyms
  • Sufentanil, N-[4-(Methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropanamide
  • Dsuvia (brand name)
  • Sufenta (brand name)
  • ARX 04

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from petroleum etherexp.
Melting point
96.6 °Cexp.
Solubility
46 mg/ml /Sufentanil citrate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
386.56 g/molcalc.
Exact mass
386.2028 Dacalc.
LogP (octanol/water)
4.21calc.
Topological polar surface area
32.78 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
8calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NC2CCN(CCc3cccs3)CC2)cc1

c1ccc(NC2CCN(CCc3cccs3)CC2)cc1

3 rings, 20 atoms.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H330Fatal if inhaled.
  • H336May cause drowsiness or dizziness.
Precautionary statements (20)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sufentanil suppliers

Trading restrictions apply to this substance

Psychotropic substance

Sufentanil is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2934.91 (sufentanil and related controlled substances)

Our policy on controlled substances

Sufentanil price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Sufentanil (DEA Code Number: 9737) is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Analgesics, Opioid, Adjuvants, Anesthesia, Narcotics, Anesthetics, Intravenous.

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adjuvants, Anesthesia
  • Analgesics, Opioid
  • Anesthetics, Intravenous
  • Narcotics

Roles

  • adjuvant
  • agonist
  • anaesthesia adjuvant
  • anaesthetic
  • analgesic
  • anti-inflammatory agent
  • general anaesthetic
  • intravenous anaesthetic
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • vulnerary

Pharmacology

Sufentanil is an Opioid Agonist. The mechanism of action of sufentanil is as a Full Opioid Agonist.

How it is made

Preparation: P.A.J. Janssen, G.H.P. Van Daele, Germany patent 2610228, eidem, United States of America patent 3998834 (both to Janssen).

Sufentanil is obtained by condensation of N-(4-methoxymethylpiperidin-4-yl)-N-phenylpropionamide with 2-thiophen-2-yl-ethyl methanesulfonate.

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Sufentanil is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2934.91 (sufentanil and related controlled substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug
  • Controlled psychotropic substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sufentanil is traded under.

HS 2934.91Exact HS code

Aminorex (INN), brotizolam (INN), clotiazepam (INN), cloxazolam (INN), dextromoramide…

World exports in 2024
$18.8M
−15.2% vs 2023, imports $18.8M
2019 to 2024
Top exporters
  1. Italy26.7%
  2. United States25.5%
  3. India * partner reported21.1%
Top importers
  1. Egypt42.6%
  2. Japan11.0%
  3. Denmark6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sufentanil is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sufentanil, based on the data on this page

What is Sufentanil?

Sufentanil is an anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. It has a role as an opioid analgesic, an intravenous anaesthetic, a mu-opioid receptor agonist and an anaesthesia adjuvant.

What is the CAS number of Sufentanil?

The CAS registry number of Sufentanil is 56030-54-7.

What is the molecular formula and weight of Sufentanil?

The molecular formula of Sufentanil is C22H30N2O2S and its molar mass is 386.56 g/mol.

What is Sufentanil used for?

Sufentanil (DEA Code Number: 9737) is a Schedule II controlled substance. Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with sev…

Is Sufentanil hazardous?

Sufentanil carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sufentanil?

Sufentanil is usually classified under HS code 293491 (Aminorex (INN), brotizolam (INN), clotiazepam (INN), cloxazolam (INN), dextromoramide…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Sufentanil on CompoundList?

No. Sufentanil is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Sufentanil

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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