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Other active pharmaceutical ingredients

Sulfinpyrazone

Also known as Sulphinpyrazone, Anturane, Anturan

CAS 57-96-5Formula C23H20N2O3SMolar mass 404.49 g/molEC 200-357-4
GHS signal word: Warning. Pictograms: Harmful or irritant 66 suppliers listed
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Sulfinpyrazone chemical structure, C23H20N2O3S, CAS 57-96-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to off-white
Melting point
136 to 137
Solubility
SLIGHTLY SOL IN WATER, ALC, ETHER, MINERAL OILS
HS code
293319
Category
Other active pharmaceutical ingredients
Illustrative photo, 25 kg kraft paper sacks of white powder in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Sulfinpyrazone?

Plain description, key identifiers and synonyms

Sulfinpyrazone is a sulfoxide and a member of pyrazolidines. It has a role as a uricosuric drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
CAS number
57-96-5 CAS number cross-checked
EC number
200-357-4
Molecular formula
C23H20N2O3S
UNII
V6OFU47K3W
MDL number
MFCD00057279
InChIKey
MBGGBVCUIVRRBF-UHFFFAOYSA-N
InChI
InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
SMILES (canonical and isomeric)
C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4

Synonyms

  • Sulphinpyrazone
  • Anturane
  • Anturan
  • Diphenylpyrazone
  • Sulfoxyphenylpyrazolidine
  • Sulfinpyrazon
  • Anturidin
  • Enturen
  • Anturanil
  • Anturano
  • 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione
  • USAF GE-13
  • Sulfinpirazona
  • Sulfinpyrazonum
  • 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
  • 4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione
  • 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione
  • 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione
  • 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine
  • 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-
  • 3,5-Pyrazolidinedione, 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-
  • Sulfoxyphenylpyrazolidin
  • 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
  • Nu Sulfinpyrazone
  • Apo Sulfinpyrazone
Show all 36 synonyms
  • sulfinpirazone
  • 4-(2-(benzenesulfinyl)ethyl)-1,2-diphenylpyrazolidine-3,5-dione
  • (+/-)-Sulfinpyrazone
  • Sulfinpyrazine
  • Anturen
  • Enturan
  • Anturane (TN)
  • sulfinpyrazone (SPZ)
  • 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
  • Diphenylpyrazone, G-28315
  • Sulfinpyrazone (JAN/USP/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-whiteexp.
Melting point
136 to 137exp.
Solubility
SLIGHTLY SOL IN WATER, ALC, ETHER, MINERAL OILSexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
404.49 g/molcalc.
Exact mass
404.1195 Dacalc.
LogP (octanol/water)
3.8calc.
Topological polar surface area
57.69 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C(CCS(=O)c2ccccc2)C(=O)N(c2ccccc2)N1c1ccccc1

O=C1C(CCS(=O)c2ccccc2)C(=O)N(c2ccccc2)N1c1ccccc1

4 rings, 29 atoms. This chemical is the scaffold itself.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sulfinpyrazone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 66 suppliers
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Where suppliers are based

66 suppliers in 13 countries

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Sulfinpyrazone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Uricosuric Agents

Roles

  • antirheumatic drug
  • gout suppressant
  • pharmaceutical
  • renal agent
  • uricosuric drug

Pharmacology

Sulfinpyrazone is a phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs.

Read more

In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.

How it is made

Synthesis: pfister, hafliger, helv chim acta 44, 232 (1961).

[2-(Phenylsulfinyl)ethyl]malonic acid diethyl ester is condensed with hydrazobenzene with aid of solution of sodium ethoxide in absolute ethanol. ... (Addn) xylene & heating @...130 deg...ethanol...is removed. Sulfinpyrazone is isolated by solvent extraction...& recrystallized from ethanol. Us patent 2,700,671.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Sulfinpyrazone (INN), Ref no: 155, Annex ref: II/155

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sulfinpyrazone is traded under.

HS 2933.19Indicative HS code

Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.44B
−22.6% vs 2023, imports $6.66B
2019 to 2024
Top exporters
  1. China21.6%
  2. Switzerland * partner reported20.5%
  3. Germany19.0%
Top importers
  1. Slovenia38.4%
  2. Portugal14.1%
  3. Brazil13.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sulfinpyrazone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sulfinpyrazone, based on the data on this page

What is Sulfinpyrazone?

Sulfinpyrazone is a sulfoxide and a member of pyrazolidines. It has a role as a uricosuric drug.

What is the CAS number of Sulfinpyrazone?

The CAS registry number of Sulfinpyrazone is 57-96-5.

What is the molecular formula and weight of Sulfinpyrazone?

The molecular formula of Sulfinpyrazone is C23H20N2O3S and its molar mass is 404.49 g/mol.

What is Sulfinpyrazone used for?

Known uses and roles of Sulfinpyrazone include antirheumatic drug, gout suppressant, pharmaceutical, renal agent, uricosuric drug and 1 more.

Is Sulfinpyrazone hazardous?

Sulfinpyrazone carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sulfinpyrazone?

Sulfinpyrazone is usually classified under HS code 293319 (Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sulfinpyrazone?

CompoundList lists 66 suppliers of Sulfinpyrazone in United States, China, United Kingdom, Germany and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Sulfinpyrazone?

Suppliers quote Sulfinpyrazone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sulfinpyrazone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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