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Flavonoids and polyphenols

Swertisin

Also known as Flavocommelitin, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one, 6-C-glucopyranosyl-7-O-methylapigenin

CAS 6991-10-2Formula C22H22O10Molar mass 446.41 g/mol
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Swertisin chemical structure, C22H22O10, CAS 6991-10-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
6991-10-2
Formula
C22H22O10
Molar mass
446.41 g/mol
HS code
293299
Category
Flavonoids and polyphenols

What is Swertisin?

Plain description, key identifiers and synonyms

Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as an antioxidant, a hypoglycemic agent, an adenosine A1 receptor antagonist, an anti-inflammatory agent and a plant metabolite. It is a monomethoxyflavone, a polyphenol, a dihydroxyflavone, a monosaccharide derivative and a flavone C-glycoside. It is functionally related to an apigenin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
CAS number
6991-10-2 CAS number cross-checked
Molecular formula
C22H22O10
UNII
Q689X9SCM9
MDL number
MFCD00210560
InChIKey
ABRULANJVVJLFI-DGHBBABESA-N
InChI
InChI=1S/C22H22O10/c1-30-13-7-14-16(11(25)6-12(31-14)9-2-4-10(24)5-3-9)19(27)17(13)22-21(29)20(28)18(26)15(8-23)32-22/h2-7,15,18,20-24,26-29H,8H2,1H3/t15-,18-,20+,21-,22+/m1/s1
Canonical SMILES
COc1cc2oc(-c3ccc(O)cc3)cc(=O)c2c(O)c1C1OC(CO)C(O)C(O)C1O
Isomeric SMILES
COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O

Synonyms

  • Flavocommelitin
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
  • 6-C-glucopyranosyl-7-O-methylapigenin
  • 7-O-Methylapigenin 6-C-beta-D-glucopyranoside
  • 5,4'-dihydroxy-7-methoxy-6-C-beta-D-glucopyranosyl flavonoside
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)chromen-4-one
  • Apigenin 6-glucosyl-7-o-methyl ether
  • Swertisin (Standard)
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one
  • 6-beta-D-Glucopyranosyl-4',5-dihydroxy-7-methoxyflavone
  • Swertish
  • 4H-Benzopyran-4-one, 6-beta-D-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
  • 6-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
  • (1S)-1,5-anhydro-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-D-glucitol
  • Swertia flavin
  • Swertisin(p)
  • Genkwanin 6-C-Glucoside
  • 6-(beta-D-Glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
  • 7-O-methyl-6-C-beta-D-glucopyranosylapigenin
  • 4',5-Dihydroxy-7-methoxy-6-beta-D-glucopyranosylflavone
  • Swertisin, 98%, from Swertia diluta (Turcz.) Benth. & Hook.f.
  • 4H-1-Benzopyran-4-one, 6-beta-d-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
  • 1,5-Anhydro-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]hexitol
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
446.41 g/molcalc.
Exact mass
446.1213 Dacalc.
LogP (octanol/water)
0.39calc.
Topological polar surface area
170.1 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
4calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccc(C3CCCCO3)cc12

O=c1cc(-c2ccccc2)oc2ccc(C3CCCCO3)cc12

4 rings, 23 atoms.

24 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Swertisin suppliers

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Swertisin price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • adenosine A1 receptor antagonist
  • adenosine receptor antagonist
  • antagonist
  • anti-inflammatory agent
  • antioxidant
  • eukaryotic metabolite
  • hypoglycemic agent
  • metabolite
  • pharmaceutical
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Swertisin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Swertisin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Swertisin, based on the data on this page

What is Swertisin?

Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as an antioxidant, a hypoglycemic agent, an adenosine A1 receptor antagonist, an anti-inflammatory agent and a plant metabolite.

What is the CAS number of Swertisin?

The CAS registry number of Swertisin is 6991-10-2.

What is the molecular formula and weight of Swertisin?

The molecular formula of Swertisin is C22H22O10 and its molar mass is 446.41 g/mol.

What is Swertisin used for?

Known uses and roles of Swertisin include adenosine a1 receptor antagonist, adenosine receptor antagonist, antagonist, anti-inflammatory agent, antioxidant and 5 more.

Is Swertisin hazardous?

No GHS hazard classification for Swertisin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Swertisin?

Swertisin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Swertisin?

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What is the price of Swertisin?

Suppliers quote Swertisin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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