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Amines and amides

(-)-Synephrine

Also known as (-)-Sympatol, D-synephrine, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol

CAS 614-35-7Formula C9H13NO2Molar mass 167.21 g/mol
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(-)-Synephrine chemical structure, C9H13NO2, CAS 614-35-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
614-35-7
Formula
C9H13NO2
Molar mass
167.21 g/mol
HS code
292250
Category
Amines and amides

What is (-)-Synephrine?

Plain description, key identifiers and synonyms

D-synephrine is the D-enantiomer of synephrine. It is a conjugate base of a D-synephrine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
CAS number
614-35-7Other or deprecated CAS: 532-80-9, 94-07-5
Molecular formula
C9H13NO2
UNII
Y276ILP9M0
MDL number
MFCD01732701
InChIKey
YRCWQPVGYLYSOX-VIFPVBQESA-N
InChI
InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
Canonical SMILES
CNCC(O)c1ccc(O)cc1
Isomeric SMILES
CNC[C@@H](C1=CC=C(C=C1)O)O

Synonyms

  • (-)-Sympatol
  • D-synephrine
  • 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
  • l-Sympatol
  • Oxedrine, (-)-
  • Oxedrine ((-)-)
  • Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (-)-
  • (-)-P-Hydroxy-a-[(methylamino)methyl]benzyl alcohol
  • (-)-4-Hydroxy-a-[(methylamino)methyl]benzenemethanol
  • BENZYL ALCOHOL, p-HYDROXY-alpha-((METHYLAMINO)METHYL)-, (-)-
  • Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (.alpha.r)-
  • 4-((1R)-1-Hydroxy-2-(Methylamino)Ethyl)Phenol
  • (-)-4-Hydroxy-a-((methylamino)methyl)benzenemethanol
  • (-)-p-Hydroxy-a-((methylamino)methyl)benzyl alcohol
  • (-)-4-Hydroxy-I+--((methylamino)methyl)benzenemethanol
  • (-)-4-Hydroxy-I+--[(methylamino)methyl]benzenemethanol
  • (-)-p-Hydroxy-I+--((methylamino)methyl)benzyl alcohol
  • (-)-p-Hydroxy-I+--[(methylamino)methyl]benzyl alcohol
  • 4-((1R)-1-hydroxy-2-(methylazaniumyl)ethyl)phenolate
  • 4-[(1R)-1-hydroxy-2-(methylazaniumyl)ethyl]phenolate
  • ()-Synephrine
  • Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (-)-(9CI)
  • Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (alphar)-
  • D(-)-Synephrine
  • (-)-Oxedrine
Show all 37 synonyms
  • (R)-synephrine
  • Synephrine (R-isomer)
  • (-)-p-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
  • (-)-4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol
  • (R)-4-(1-hydroxy-2-(methylamino)ethyl)phenol
  • (alphaR)-4-Hydroxy-alpha-[(methylamino)methyl]benzenemethanol
  • (-)-p-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
  • (R)-4-[1-Hydroxy-2-(methylamino)ethyl]phenol
  • Adrenaline Impurity 68
  • 614-35-7 (R-isomer)
  • Synephrine,(+/-)
  • (R)-(-)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
167.21 g/molcalc.
Exact mass
167.0946 Dacalc.
LogP (octanol/water)
0.64calc.
Topological polar surface area
52.49 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(-)-Synephrine suppliers

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(-)-Synephrine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Synephrine is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Synephrine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Synephrine, based on the data on this page

What is (-)-Synephrine?

D-synephrine is the D-enantiomer of synephrine. It is a conjugate base of a D-synephrine(1+).

What is the CAS number of (-)-Synephrine?

The CAS registry number of (-)-Synephrine is 614-35-7. Other or deprecated CAS numbers: 532-80-9, 94-07-5.

What is the molecular formula and weight of (-)-Synephrine?

The molecular formula of (-)-Synephrine is C9H13NO2 and its molar mass is 167.21 g/mol.

What is (-)-Synephrine used for?

Use classes: Pharmaceuticals.

Is (-)-Synephrine hazardous?

No GHS hazard classification for (-)-Synephrine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (-)-Synephrine?

(-)-Synephrine is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Synephrine?

Post a free request on CompoundList and suppliers of (-)-Synephrine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Synephrine?

Suppliers quote (-)-Synephrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Synephrine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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