CompoundList
Sign in
Alkaloids

Synephrine

Also known as Oxedrine, p-Synephrine, Parasympatol

CAS 94-07-5Formula C9H13NO2Molar mass 167.21 g/molEC 202-300-9
GHS signal word: Warning. Pictograms: Harmful or irritant 72 suppliers listed
Get quotes Compare 72 suppliers
Synephrine chemical structure, C9H13NO2, CAS 94-07-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
94-07-5
Formula
C9H13NO2
Molar mass
167.21 g/mol
EC number
202-300-9
HS code
293979
Category
Alkaloids

What is Synephrine?

Plain description, key identifiers and synonyms

Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as an alpha-adrenergic agonist and a plant metabolite. It is a member of ethanolamines, a member of phenols and a phenethylamine alkaloid. It is a conjugate base of a synephrinium.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[1-hydroxy-2-(methylamino)ethyl]phenol
CAS number
94-07-5 CAS number cross-checkedOther or deprecated CAS: 582-84-3
EC number
202-300-9
Molecular formula
C9H13NO2
UNII
PEG5DP7434
MDL number
MFCD00002370
INCI name
SYNEPHRINE
InChIKey
YRCWQPVGYLYSOX-UHFFFAOYSA-N
InChI
InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3
SMILES (canonical and isomeric)
CNCC(C1=CC=C(C=C1)O)O

Synonyms

  • Oxedrine
  • p-Synephrine
  • Parasympatol
  • Analeptin
  • Simpalon
  • Sympatol
  • Synthenate
  • Sympathol
  • Ethaphene
  • DL-Synephrine
  • 4-[1-Hydroxy-2-(methylamino)ethyl]phenol
  • 4-(1-Hydroxy-2-(methylamino)ethyl)phenol
  • Advantra z
  • 1-(4-Hydroxyphenyl)-2-methylaminoethanol
  • beta-Methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol
  • 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol
  • Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-
  • 4-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
  • p-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
  • p-Hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
  • 4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol
  • Benzenemethanol, 4-hydroxy-alpha-[(methylamino)methyl]-
  • 1-[4-Hydroxyphenyl]-2-methylaminoethanol
  • (+-)-synephrine
  • (+/-)-Synephrine
Show all 37 synonyms
  • Sympaethamine
  • Sympaethamin
  • Synephrin
  • Simpatol
  • p-Oxedrine
  • Synefrin
  • rac-Synephrine
  • 1-(4-Hydroxyphenyl)-N-methylethanolamine
  • (RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol
  • Synephrine (Standard)
  • 4-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • ( inverted exclamation markA)-Synephrine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
167.21 g/molcalc.
Exact mass
167.0946 Dacalc.
LogP (octanol/water)
0.64calc.
Topological polar surface area
52.49 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Synephrine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 72 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

72 suppliers in 11 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Synephrine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name SYNEPHRINE(skin protecting)

Pharmacological actions

  • Adrenergic alpha-Agonists
  • Nasal Decongestants
  • Sympathomimetics
  • Vasoconstrictor Agents

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • eukaryotic metabolite
  • metabolite
  • neurotransmitter agent
  • pharmaceutical
  • plant metabolite

Functional uses

  • Humectant

Cosmetic functions

  • Skin protecting

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Synephrine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Synephrine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Synephrine, based on the data on this page

What is Synephrine?

Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as an alpha-adrenergic agonist and a plant metabolite. It is a member of ethanolamines, a member of phenols and a phenethylamine alkaloid.

What is the CAS number of Synephrine?

The CAS registry number of Synephrine is 94-07-5. Other or deprecated CAS numbers: 582-84-3.

What is the molecular formula and weight of Synephrine?

The molecular formula of Synephrine is C9H13NO2 and its molar mass is 167.21 g/mol.

What is Synephrine used for?

Known uses and roles of Synephrine include skin conditioning agents in cosmetics and personal care, adrenergic agent, adrenergic agonist, alpha-adrenergic agonist, alpha-adrenergic drug and 11 more.

Is Synephrine hazardous?

Synephrine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Synephrine?

Synephrine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Synephrine?

CompoundList lists 72 suppliers of Synephrine in China, United States, Hong Kong, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Synephrine in India?

1 supplier in India list Synephrine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Synephrine?

Suppliers quote Synephrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Synephrine

Get quotes for Synephrine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Synephrine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Synephrine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/synephrine-94-07-5" title="Synephrine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Alkaloids or HS code 293979

72 suppliers
Free quotes, contact stays private
Get quotes