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Heterocyclic building blocks

Tacrine

Also known as 1,2,3,4-tetrahydroacridin-9-amine, Tetrahydroaminacrine, 1,2,3,4-Tetrahydro-9-acridinamine

CAS 321-64-2Formula C13H14N2Molar mass 198.27 g/molEC 206-291-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 80 suppliers listed
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Tacrine chemical structure, C13H14N2, CAS 321-64-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
321-64-2
Formula
C13H14N2
Molar mass
198.27 g/mol
EC number
206-291-2
HS code
293399
Category
Heterocyclic building blocks

What is Tacrine?

Plain description, key identifiers and synonyms

Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,2,3,4-tetrahydroacridin-9-amine
CAS number
321-64-2 CAS number cross-checkedOther or deprecated CAS: 206658-92-6
EC numbers
206-291-2, 693-573-7
Molecular formula
C13H14N2
UNII
4VX7YNB537
MDL number
MFCD00046923
InChIKey
YLJREFDVOIBQDA-UHFFFAOYSA-N
InChI
InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
SMILES (canonical and isomeric)
C1CCC2=NC3=CC=CC=C3C(=C2C1)N

Synonyms

  • 1,2,3,4-tetrahydroacridin-9-amine
  • Tetrahydroaminacrine
  • 1,2,3,4-Tetrahydro-9-acridinamine
  • Tetrahydroaminoacridine
  • Tetrahydroaminocrin
  • Tetrahydroaminocrine
  • 9-amino-1,2,3,4-tetrahydroacridine
  • Tacrina
  • Tacrinal
  • Tacrinum
  • 9-Acridinamine, 1,2,3,4-tetrahydro-
  • 1,2,3,4-Tetrahydro-9-aminoacridine
  • 5-Amino-6,7,8,9-tetrahydroacridine
  • 1,2,3,4-Tetrahydroaminoacridine
  • Cognex
  • Acridine, 1,2,3,4-tetrahydro-9-amino-
  • 2aox
  • Tacrine (INN)
  • tha
  • Acridine, 9-amino-1,2,3,4-tetrahydro-
  • tacrine.HCl
  • Sdccgsbi-0050025.p004
  • 5,6,7,8-tetrahydroacridine-9-ylamine
  • Tacrinal (TN)
  • 5-Amino-6,7,8,9-tetrahydroacridine (European)
Show all 32 synonyms
  • 1,2,3,4-Tetrahydro-acridin-9-ylamine
  • Tracine
  • 9-Aminotetrahydroacridine
  • 1acj
  • 2aow
  • 1,2,3,4-Tetrahydro-9-acridineamine
  • Romotal (Salt/Mix)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
198.27 g/molcalc.
Exact mass
198.1157 Dacalc.
LogP (octanol/water)
2.7calc.
Topological polar surface area
38.91 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
15calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2nc3c(cc2c1)CCCC3

c1ccc2nc3c(cc2c1)CCCC3

3 rings, 14 atoms, the 1,2,3,4-Tetrahydroacridine ring system.

235 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H335May cause respiratory irritation.
  • H351Suspected of causing cancer.
Precautionary statements (24)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tacrine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 80 suppliers
30 of 30 offers
  • Alchem Pharmtech, Inc.
    United States ManufacturerUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • Shanghai Pinewood
    China, ShanghaiUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • 001Chemical
    China, HangzhouUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • ABCR GmbH & CO. KG
    GermanyUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View
  • Accel Scientific S.L.
    Spain, BarcelonaUnclaimed profile
    TacrineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

80 suppliers in 14 countries

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Tacrine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Cholinesterase Inhibitors
  • Nootropic Agents
  • Parasympathomimetics

Roles

  • enzyme inhibitor

Pharmacology

Tacrine is a Cholinesterase Inhibitor. The mechanism of action of tacrine is as a Cholinesterase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tacrine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tacrine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tacrine, based on the data on this page

What is Tacrine?

Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine.

What is the CAS number of Tacrine?

The CAS registry number of Tacrine is 321-64-2. Other or deprecated CAS numbers: 206658-92-6.

What is the molecular formula and weight of Tacrine?

The molecular formula of Tacrine is C13H14N2 and its molar mass is 198.27 g/mol.

What is Tacrine used for?

Known uses and roles of Tacrine include building blocks in research and laboratory, screening compounds in research and laboratory, enzyme inhibitor, cholinesterase inhibitors, nootropic agents and 1 more.

Is Tacrine hazardous?

Tacrine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tacrine?

Tacrine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tacrine?

CompoundList lists 80 suppliers of Tacrine in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tacrine?

Suppliers quote Tacrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tacrine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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