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Cosmetic antioxidants

Thiodiglycol

Also known as 2,2'-Thiodiethanol, Thiodiethylene glycol, Thiodiethanol

CAS 111-48-8Formula C4H10O2SMolar mass 122.19 g/molEC 203-874-3
GHS signal word: Warning. Pictograms: Harmful or irritant Controlled, licensed buyers only
Request as a licensed buyer Safety data
Thiodiglycol chemical structure, C4H10O2S, CAS 111-48-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Liquid
Melting point
-10.2 °C
Boiling point
282 °C
Density
1.1793 g/cm³ at 25 °C
Flash point
113 °C
HS code
293070
Category
Cosmetic antioxidants

What is Thiodiglycol?

Plain description, key identifiers and synonyms

Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2-hydroxyethylsulfanyl)ethanol
CAS number
111-48-8 CAS number cross-checked
EC number
203-874-3
Molecular formula
C4H10O2S
UNII
9BW5T43J04
MDL number
MFCD00002910
INCI name
THIODIGLYCOL
InChIKey
YODZTKMDCQEPHD-UHFFFAOYSA-N
InChI
InChI=1S/C4H10O2S/c5-1-3-7-4-2-6/h5-6H,1-4H2
SMILES (canonical and isomeric)
C(CSCCO)O

Synonyms

  • 2,2'-Thiodiethanol
  • Thiodiethylene glycol
  • Thiodiethanol
  • Tedegyl
  • Kromfax solvent
  • Bis(2-hydroxyethyl) sulfide
  • 2,2'-Thiobisethanol
  • Bis(2-hydroxyethyl)sulfide
  • 2-(2-hydroxyethylsulfanyl)ethanol
  • Ethanol, 2,2'-thiobis-
  • Glyecine A
  • 2,2'-Thiodiglycol
  • Tiodiglicol
  • Di(2-hydroxyethyl) sulfide
  • Bis(2-hydroxyethyl) thioether
  • bis(hydroxyethyl)sulfide
  • Thiodiglycolum
  • Tiodiglicolo
  • beta-Hydroxyethyl sulfide
  • Sulfide, bis(2-hydroxyethyl)
  • Bis(beta-hydroxyethyl) sulfide
  • beta,beta'-Dihydroxyethyl sulfide
  • 2,2'-sulfobisethanol
  • beta,beta'-Dihydroxydiethyl sulfide
  • Bis(beta-hydroxyethyl)sulfide
Show all 36 synonyms
  • 2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
  • 2-((2-hydroxyethyl)sulfanyl)ethan-1-ol
  • 2,2-Thiodiethanol
  • Ethanol, 2,2'-thiodi-
  • Dihydroxyethyl sulfide
  • Diethanol sulfide
  • 2,2'-Thiobis(ethanol)
  • 3-Thiapentane-1,5-diol
  • beta-Thiodiglycol
  • Kromfax@ Solvent
  • Bis(2-hydroxyethyl) sulphide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Liquidexp.
Odour
Characteristic odorexp.
Melting point
-10.2 °Cexp.
Boiling point
282 °Cexp.
Density
1.1793 g/cm³ at 25 °Cexp.
Flash point
113 °Cexp.
Autoignition temperature
298 °Cexp.
Solubility
In water, miscible at 20 °Cexp.
Vapour pressure
5.09 × 10⁻⁴ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
122.19 g/molcalc.
Exact mass
122.0402 Dacalc.
LogP (octanol/water)
-0.3calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
7calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
120NFPA 704 rating

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thiodiglycol suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Chemical Weapons Convention Schedule 2

Thiodiglycol is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: OPCW Chemical Weapons Convention Schedule 2, HS 2022 subheading 2930.70 (thiodiglycol)

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for Thiodiglycol with their licence. Our compliance team reviews it before suppliers see it.

Request as a licensed buyer

Thiodiglycol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Intermediate for elastomers and antioxidants, solvent for dyes in textile printing.

Thiodiglycol is used as a precursor for sulfur mustard ... It is also an important primary metabolite of sulfur mustard formed by simple hydrolysis.

Schedule 2B precursor to mustard gas, sesquimustard, HT, T, and Q.

The chemical thiodiglycol is used to manufacture ball-point pen ink and is also a precursor for mustard gas.

As an ingredient in printer ink cartridges.

Industrial uses: Stabilizing agent, Intermediate.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name THIODIGLYCOL(antioxidant)

Pharmacological actions

  • Enzyme Inhibitors

Roles

  • antineoplastic agent
  • antioxidant
  • metabolite
  • pharmaceutical
  • solvent

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Pharmacology

Thiodiglycol is a hydrolysis product of mustard gas, an alkylating agent, with antineoplastic activity.

How it is made

Prepared from ethylene oxide and hydrogen sulfide.

Hydrolysis of dichloroethyl sulfide, interaction of ethylene chlorohydrin and sodium sulfide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Chemical Weapons Convention Schedule 2

Thiodiglycol is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: OPCW Chemical Weapons Convention Schedule 2, HS 2022 subheading 2930.70 (thiodiglycol)

Our policy on controlled substances

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 603-081-00-6

Health and food

  • EU cosmetic ingredient inventory

Controls

  • Chemical Weapons Convention Schedule 2

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiodiglycol is traded under.

HS 2930.70Exact HS code

Bis(2-hydroxyethyl)sulfide (thiodiglycol (INN))

World exports in 2024
$3.55M
+8.4% vs 2023, imports $3.15M
2019 to 2024
Top exporters
  1. Germany64.0%
  2. China26.6%
  3. United States4.8%
Top importers
  1. South Korea23.4%
  2. United States22.3%
  3. Canada16.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiodiglycol is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiodiglycol, based on the data on this page

What is Thiodiglycol?

Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol.

What is the CAS number of Thiodiglycol?

The CAS registry number of Thiodiglycol is 111-48-8.

What is the molecular formula and weight of Thiodiglycol?

The molecular formula of Thiodiglycol is C4H10O2S and its molar mass is 122.19 g/mol.

What is Thiodiglycol used for?

Intermediate for elastomers and antioxidants, solvent for dyes in textile printing. Thiodiglycol is used as a precursor for sulfur mustard ... It is also an important primary metabolite of sulfur mustard formed by simple hydrolysis. Schedule 2B precursor to mustard gas, sesquimustard, HT, T, and Q.

Is Thiodiglycol hazardous?

Thiodiglycol carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thiodiglycol?

Thiodiglycol is usually classified under HS code 293070 (Bis(2-hydroxyethyl)sulfide (thiodiglycol (INN))). This is indicative, confirm it with your customs broker before shipping.

Can I buy Thiodiglycol on CompoundList?

Thiodiglycol is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Thiodiglycol

Request as a licensed buyer

Upload your licence with the request. Our compliance team reviews it before the documented suppliers see it.
Request as a licensed buyer
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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