CompoundList
Sign in
Antibiotics and anti-infectives

Thiostrepton

Also known as Bryamycin, Thiactin, Gargon

CAS 1393-48-2Formula C72H85N19O18S5Molar mass 1,664.92 g/molEC 215-734-9
GHS signal word: Warning. Pictograms: Harmful or irritant 4 suppliers listed
Get quotes Compare 4 suppliers
Thiostrepton chemical structure, C72H85N19O18S5, CAS 1393-48-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1393-48-2
Formula
C72H85N19O18S5
Molar mass
1,664.92 g/mol
EC number
215-734-9
HS code
293410
Category
Antibiotics and anti-infectives

What is Thiostrepton?

Plain description, key identifiers and synonyms

Thiostrepton is a naturally-occurring, sulfur-rich, cyclic oligopeptide antibiotic of the thiopeptide class, and an irreversible inhibitor of the mitochondrial thioredoxin-dependent peroxide reductase (peroxiredoxin-3, PRX3, antioxidant protein 1, AOP-1), with potential antineoplastic activity. Upon intrapleural administration, thiostrepton irreversibly binds to and inhibits the activity of PRX3. This inhibits the peroxidase activity of the thioredoxin reductase 2 (TXNRD2)-thioredoxin-2 (TRX2)-PRX3 antioxidant signaling network within the mitochondria, which may result in the accumulation of hydrogen peroxide and lead to tumor cell death. PRX3 is upregulated in cancer cells and plays an important role in the regulation of the oxidative stress pathways.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(11E)-37-butan-2-yl-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide
CAS number
1393-48-2 CAS number cross-checked
EC number
215-734-9
Molecular formula
C72H85N19O18S5
InChIKey
NSFFHOGKXHRQEW-DVRIZHICSA-N
InChI
InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15+
Canonical SMILES
C=C(NC(=O)C(=C)NC(=O)c1csc(C2=NC3c4csc(n4)C4NC(=O)c5csc(n5)C(C(C)(O)C(C)O)NC(=O)C5CSC(=N5)C(=CC)NC(=O)C(C(C)O)NC(=O)c5csc(n5)C3(CC2)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC(=O)C(C(C)CC)NC2C=Cc3c(C(C)O)cc(nc3C2O)C(=O)OC4C)n1)C(N)=O
Isomeric SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C\C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

Synonyms

  • Bryamycin
  • Thiactin
  • Gargon
  • Thiostrepton a
  • RSO 021

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,664.92 g/molcalc.
Exact mass
1,663.4924 Dacalc.
LogP (octanol/water)
0.77calc.
Topological polar surface area
562.7 Ųcalc.
Hydrogen bond donors
17calc.
Hydrogen bond acceptors
31calc.
Rotatable bonds
12calc.
Heavy atoms
114calc.
Rings
10calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
17calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1NC(=O)CNC(=O)CNC2C=Cc3ccc(nc3C2)C(=O)OCC2NC(=O)c3csc(n3)CNC(=O)C3CSC(=N3)C(=C)NC(=O)CNC(=O)c3csc(n3)C3(CCC(c4nccs4)=NC3c3csc2n3)NC(=O)CNC1=O

C=C1NC(=O)CNC(=O)CNC2C=Cc3ccc(nc3C2)C(=O)OCC2NC(=O)c3csc(n3)CNC(=O)C3CSC(=N3)C(=C)NC(=O)CNC(=O)c3csc(n3)C3(CCC(c4nccs4)=NC3c3csc2n3)NC(=O)CNC1=O

10 rings, 80 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thiostrepton suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 3 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Thiostrepton price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • ferroptosis inducer
  • metabolite
  • pathway inhibitor
  • pharmaceutical
  • protein synthesis inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiostrepton is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiostrepton is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiostrepton, based on the data on this page

What is Thiostrepton?

Thiostrepton is a naturally-occurring, sulfur-rich, cyclic oligopeptide antibiotic of the thiopeptide class, and an irreversible inhibitor of the mitochondrial thioredoxin-dependent peroxide reductase (peroxiredoxin-3, PRX3, antioxidant protein 1, AOP-1), with potential antineoplastic activity.

What is the CAS number of Thiostrepton?

The CAS registry number of Thiostrepton is 1393-48-2.

What is the molecular formula and weight of Thiostrepton?

The molecular formula of Thiostrepton is C72H85N19O18S5 and its molar mass is 1,664.92 g/mol.

What is Thiostrepton used for?

Use classes: Animal Drugs.

Is Thiostrepton hazardous?

Thiostrepton carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thiostrepton?

Thiostrepton is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thiostrepton?

CompoundList lists 4 suppliers of Thiostrepton in United States, China and Israel. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Thiostrepton?

Suppliers quote Thiostrepton on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Thiostrepton

Get quotes for Thiostrepton

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Thiostrepton
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Thiostrepton with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/thiostrepton-1393-48-2" title="Thiostrepton structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Antibiotics and anti-infectives or HS code 293410

4 suppliers
Free quotes, contact stays private
Get quotes