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Analgesics and anti-inflammatories

Tilidine

Also known as Tilidate, trans-Tilidine, dl-trans-Tilidine

CAS 51931-66-9Formula C17H23NO2Molar mass 273.38 g/molEC 243-774-7
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade
Why it is not for trade
Tilidine chemical structure, C17H23NO2, CAS 51931-66-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51931-66-9
Formula
C17H23NO2
Molar mass
273.38 g/mol
EC number
243-774-7
HS code
292244
Category
Analgesics and anti-inflammatories

What is Tilidine?

Plain description, key identifiers and synonyms

Dextilidine is an ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has S configuration at the carbon bearing the phenyl group and R configuration at the carbon bearing the dimethylamino group. The opioid analgesic tilidine is the racemate comprising equimolar amounts of dextilidine and its enantiomer, ent-dextilidine. A prodrug, tilidine is converted by the liver to the active analgesic, nortilidine, virtually all of the opioid activity resides in the (1S,2R) isomer (i.e. the isomer derived from dextilidine). It has a role as an opioid analgesic and a prodrug. It is an enantiomer of an ent-dextilidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
CAS number
51931-66-9Other or deprecated CAS: 20380-58-9, 32447-90-8
EC numbers
243-774-7, 251-048-6, 257-522-9
Molecular formula
C17H23NO2
UNII
2728MV084C, GY33N31E9Y
InChIKey
WDEFBBTXULIOBB-WBVHZDCISA-N
InChI
InChI=1S/C17H23NO2/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3/h5-8,10-12,15H,4,9,13H2,1-3H3/t15-,17+/m1/s1
Canonical SMILES
CCOC(=O)C1(c2ccccc2)CCC=CC1N(C)C
Isomeric SMILES
CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2

Synonyms

  • Tilidate
  • trans-Tilidine
  • dl-trans-Tilidine
  • ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, (1R,2S)-rel-
  • Go 1261
  • Godecke, Tilidin
  • Go1261
  • Dextilidine
  • Dextilidina
  • Dextilidinum
  • Ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • Tilidine (INN)
  • DEA No. 9750
  • (+)-Ethyl trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate
  • Tilidin
  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, trans-
  • (+)-tilidine
  • Tilidine, (+)-
  • Tilidine, trans-(+)-
  • (+)-(1S,2R)-Ethyl-2-dimethylamino-1-phenyl-3-cyclohexen-1-carboxylat
  • (+)-(1S,2R)-ethyl-2-dimethylamino-1-phenyl-3-cyclohexen-1-carboxylate
  • (1S,2R)-(+)-ethyl-2-dimethylamino-1-phenyl-3-cyclohexen-1-carboxylate
  • (+/-)-Ethyl trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate
  • Ethyl (1S,6R)-6-(dimethylamino)-3,6-dihydro[1,1'-biphenyl]-1(2H)-carboxylate
Show all 27 synonyms
  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, (trans)-(+/-)-
  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester,(1S-trans)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
273.38 g/molcalc.
Exact mass
273.1729 Dacalc.
LogP (octanol/water)
2.77calc.
Topological polar surface area
29.54 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CCC(c2ccccc2)CC1

C1=CCC(c2ccccc2)CC1

2 rings, 12 atoms, the 4-Phenylcyclohexene ring system.

93 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tilidine suppliers

Trading restrictions apply to this substance

Narcotic drug

Tilidine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2922.44 (tilidine)

Our policy on controlled substances

Tilidine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Analgesics, Opioid
  • Narcotics

Roles

  • analgesic
  • opioid analgesic
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Tilidine is a synthetic opioid and a prodrug form of nortilidine, that can be used to treat moderate to severe acute and chronic pain. Upon administration, tilidine is metabolized to its active metabolite nortilidine, which crosses the blood-brain barrier (BBB), and binds to and activates the mu-opioid receptor. This induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Tilidine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2922.44 (tilidine)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tilidine is traded under.

HS 2922.44Exact HS code

Tilidine (INN) and its salts

World exports in 2024
$22.2M
+252% vs 2023, imports $22.7M
2019 to 2024
Top exporters
  1. Germany93.8%
  2. India * partner reported3.4%
  3. Slovakia1.1%
Top importers
  1. Serbia * partner reported93.9%
  2. United States3.1%
  3. Poland0.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tilidine is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tilidine, based on the data on this page

What is Tilidine?

Dextilidine is an ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has S configuration at the carbon bearing the phenyl group and R configuration at the carbon bearing the dimethylamino group.

What is the CAS number of Tilidine?

The CAS registry number of Tilidine is 51931-66-9. Other or deprecated CAS numbers: 20380-58-9, 32447-90-8.

What is the molecular formula and weight of Tilidine?

The molecular formula of Tilidine is C17H23NO2 and its molar mass is 273.38 g/mol.

What is Tilidine used for?

Known uses and roles of Tilidine include analgesics and antipyretics in pharmaceuticals, cns agents in pharmaceuticals, analgesic, opioid analgesic, pharmaceutical and 4 more.

Is Tilidine hazardous?

Tilidine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tilidine?

Tilidine is usually classified under HS code 292244 (Tilidine (INN) and its salts). This is indicative, confirm it with your customs broker before shipping.

Can I buy Tilidine on CompoundList?

No. Tilidine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Tilidine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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