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Antibiotics and anti-infectives

Tipranavir

Also known as 2-Pyridinesulfonamide, N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-, N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide, 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide

CAS 174484-41-4Formula C31H33F3N2O5SMolar mass 602.68 g/molEC 629-839-6
GHS hazard pictograms. Pictograms: Hazardous to the environment 28 suppliers listed Drug substance
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Tipranavir chemical structure, C31H33F3N2O5S, CAS 174484-41-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White solid from ethyl acetate + heptane
Melting point
86 to 89
Solubility
Freely soluble in dehydrated alcohol, propylene glycol. Insoluble in aqueous buffer, pH…
HS code
293590
Category
Antibiotics and anti-infectives
Illustrative photo, fine white powder in an amber glass reagent bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Tipranavir?

Plain description, key identifiers and synonyms

Tipranavir is a pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor. It has a role as a HIV protease inhibitor and an antiviral drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
CAS number
174484-41-4 CAS number cross-checked
EC number
629-839-6
Molecular formula
C31H33F3N2O5S
UNII
ZZT404XD09
InChIKey
SUJUHGSWHZTSEU-FYBSXPHGSA-N
InChI
InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
Canonical SMILES
CCCC1(CCc2ccccc2)CC(O)=C(C(CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1
Isomeric SMILES
CCC[C@]1(CC(=C(C(=O)O1)[C@H](CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=CC=C4

Synonyms

  • 2-Pyridinesulfonamide, N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-
  • N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
  • 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
  • 2-Pyridinesulfonamide, N-(3-((1R)-1-((6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)-
  • 2-Pyridinesulfonamide, N-(3-(1-(5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)-, (R-(R*,R*))-
  • tipranavirum
  • N-(3-((1R)-1-((2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl)propyl)phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
  • tipranavir, (R-(R*,R*))-
  • Aptivus
  • TPV
  • Tipranavir (INN)
  • N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
  • N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)-2-pyridinesulfonamide
  • N-{3-[(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl]phenyl}-5-(trifluoromethyl)pyridine-2-sulfonamide
  • Aptivus(TM)
  • N-(3-((R)-1-((R)-4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
  • Aptivus (TN)
  • PNU 140690
  • Tipranavir?
  • Tipranavir (Standard)
  • Tipranavir Impurity 1
  • 1d4y
  • 2o4l
  • 2o4n
  • 2o4p
Show all 27 synonyms
  • N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
  • Tipranavir - Bio-X trade mark

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White solid from ethyl acetate + heptaneexp.
Melting point
86 to 89exp.
Solubility
Freely soluble in dehydrated alcohol, propylene glycol. Insoluble in aqueous buffer, pH 7.5exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
602.68 g/molcalc.
Exact mass
602.2062 Dacalc.
LogP (octanol/water)
7.33calc.
Topological polar surface area
105.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
11calc.
Heavy atoms
42calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OC(CCc2ccccc2)CC=C1Cc1cccc(NS(=O)(=O)c2ccccn2)c1

O=C1OC(CCc2ccccc2)CC=C1Cc1cccc(NS(=O)(=O)c2ccccn2)c1

4 rings, 32 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (3)
  • P273Avoid release to the environment.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tipranavir suppliers

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All 28 suppliers
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Where suppliers are based

28 suppliers in 10 countries

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Tipranavir price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Anti-HIV Agents

Roles

  • HIV protease inhibitor
  • anti-HIV agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antiviral agent
  • antiviral drug
  • enzyme inhibitor
  • pharmaceutical
  • protease inhibitor

Pharmacology

Tipranavir is a Protease Inhibitor. The mechanism of action of tipranavir is as a HIV Protease Inhibitor.

How it is made

Preparation: K.R. Romines et al., WO 9530670 (1995 to Upjohn), eidem, US 5852195 (1998 to Pharmacia & Upjohn)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tipranavir is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tipranavir is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tipranavir, based on the data on this page

What is Tipranavir?

Tipranavir is a pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor. It has a role as a HIV protease inhibitor and an antiviral drug.

What is the CAS number of Tipranavir?

The CAS registry number of Tipranavir is 174484-41-4.

What is the molecular formula and weight of Tipranavir?

The molecular formula of Tipranavir is C31H33F3N2O5S and its molar mass is 602.68 g/mol.

What is Tipranavir used for?

Known uses and roles of Tipranavir include antivirals in pharmaceuticals, hiv protease inhibitor, anti-hiv agent, antiinfective agent, antimicrobial agent and 7 more.

Is Tipranavir hazardous?

Tipranavir has a GHS hazard classification. Main hazards: toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tipranavir?

Tipranavir is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tipranavir?

CompoundList lists 28 suppliers of Tipranavir in China, United States, Canada, Germany and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tipranavir in India?

1 supplier in India list Tipranavir on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tipranavir?

Suppliers quote Tipranavir on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tipranavir

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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