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Cardiovascular and metabolic drugs

Trimethaphan

Also known as Trimetaphan, Thimethaphan, Trimetaphanum

CAS 7187-66-8Formula C22H25N2OS+Molar mass 365.52 g/mol
1 supplier listed
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Trimethaphan chemical structure, C22H25N2OS+, CAS 7187-66-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
7187-66-8
Formula
C22H25N2OS+
Molar mass
365.52 g/mol
HS code
293499
Category
Cardiovascular and metabolic drugs

What is Trimethaphan?

Plain description, key identifiers and synonyms

Trimethaphan is a complex heterocyclic sulfonium compound with an imidazolium core, used to treat hypertension. It has a role as a vasodilator agent, an antihypertensive agent, a nicotinic antagonist and an anaesthesia adjuvant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3,5-dibenzyl-8-thionia-3,5-diazatricyclo[6.3.0.02,6]undecan-4-one
CAS number
7187-66-8 CAS number cross-checked
Molecular formula
C22H25N2OS+
UNII
6G8X656T45
InChIKey
CHQOEHPMXSHGCL-UHFFFAOYSA-N
InChI
InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1
SMILES (canonical and isomeric)
C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5

Synonyms

  • Trimetaphan
  • Thimethaphan
  • Trimetaphanum
  • Trimethaphan ion
  • Trimethaphan cation
  • 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium
  • Thieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)-
  • 1,3-Dibenzyl-2-oxodecahydrothieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium
  • 3,5-dibenzyl-4-oxo-8$l^(4)-thia-3,5-diazatricyclo(6.3.0.0^(2,6))undecan-8-ylium
  • 3,5-dibenzyl-4-oxo-8$l^{4}-thia-3,5-diazatricyclo[6.3.0.0^{2,6}]undecan-8-ylium
  • 3,5-dibenzyl-8-thionia-3,5-diazatricyclo[6.3.0.02,6]undecan-4-one
  • PDSP1_000122
  • PDSP2_000122
  • Thieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)- (VAN)
  • Thieno(1',2':1,2)thieno(3,4-d)imidazolium, decahydro-2-oxo-1,3-bis(phenylmethyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
365.52 g/molcalc.
Exact mass
365.1682 Dacalc.
LogP (octanol/water)
3.66calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
26calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.41calc.
Formal charge
1calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

5 rings, 26 atoms. This chemical is the scaffold itself.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Trimethaphan suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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  • EvitaChem
    China, BeijingUnclaimed profile
    TrimethaphanGrade, purity and minimum order on request
    Price on request
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Where suppliers are based

1 supplier in 1 country

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Trimethaphan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

Blocks receptors in ganglia.

Vasodepresor agent.

Therapeutic category: Antihypertensive (Trimethaphan camsylate).

Pharmacological actions

  • Adjuvants, Anesthesia
  • Antihypertensive Agents
  • Ganglionic Blockers
  • Nicotinic Antagonists

Roles

  • PPAR modulator
  • adjuvant
  • agonist
  • anaesthesia adjuvant
  • antihypertensive agent
  • cardiovascular drug
  • cholinergic antagonist
  • cholinergic drug
  • hypoglycemic agent
  • insulin-sensitizing drug
  • neurotransmitter agent
  • nicotinic antagonist
  • pharmaceutical
  • vasodilator agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trimethaphan is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Trimethaphan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trimethaphan, based on the data on this page

What is Trimethaphan?

Trimethaphan is a complex heterocyclic sulfonium compound with an imidazolium core, used to treat hypertension. It has a role as a vasodilator agent, an antihypertensive agent, a nicotinic antagonist and an anaesthesia adjuvant.

What is the CAS number of Trimethaphan?

The CAS registry number of Trimethaphan is 7187-66-8.

What is the molecular formula and weight of Trimethaphan?

The molecular formula of Trimethaphan is C22H25N2OS+ and its molar mass is 365.52 g/mol.

What is Trimethaphan used for?

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. Blocks receptors in ganglia. Vasodepresor agent. Therapeutic category: Antihypertensive (Trimethaphan camsylate).

Is Trimethaphan hazardous?

No GHS hazard classification for Trimethaphan is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Trimethaphan?

Trimethaphan is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trimethaphan?

CompoundList lists 1 supplier of Trimethaphan in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trimethaphan?

Suppliers quote Trimethaphan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trimethaphan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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