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Screening compounds

Troglitazone

Also known as Rezulin, Romglizone, Prelay

CAS 97322-87-7Formula C24H27NO5SMolar mass 441.55 g/mol
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Troglitazone chemical structure, C24H27NO5S, CAS 97322-87-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
97322-87-7
Formula
C24H27NO5S
Molar mass
441.55 g/mol
HS code
293410
Category
Screening compounds

What is Troglitazone?

Plain description, key identifiers and synonyms

Troglitazone is a member of chromanes and a thiazolidinone. It has a role as a ferroptosis inhibitor, an antioxidant, a hypoglycemic agent, an antineoplastic agent, a vasodilator agent, an anticonvulsant, an anticoagulant, a platelet aggregation inhibitor and an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS number
97322-87-7 CAS number cross-checked
Molecular formula
C24H27NO5S
UNII
I66ZZ0ZN0E
MDL number
MFCD00878416
InChIKey
GXPHKUHSUJUWKP-UHFFFAOYSA-N
InChI
InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
SMILES (canonical and isomeric)
CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C

Synonyms

  • Rezulin
  • Romglizone
  • Prelay
  • Romozin
  • Noscal
  • troglitazona
  • troglitazonum
  • 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
  • 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
  • 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-
  • 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
  • 2,4-thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-
  • 5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
  • 5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione
  • 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-2,4-Thiazolidinedione
  • 5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-1,3-thiazolidine-2,4-dione
  • 5-((4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)phenyl)methyl)-1,3-thiazolidine-2,4-dione
  • 5-(4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy)benzyl)-1,3-thiazolidine-2,4-dione
  • 5-[[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)-2,4-thiazolidinedione
  • 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione)-T
  • Rezulin (TN)
  • CI 991
  • GR 92132X
  • (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
Show all 34 synonyms
  • 5-(4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione
  • Troglitazone (CS-045)
  • 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • Troglitazone (JAN/USAN/INN)
  • Troglitazone (Standard)
  • (+/-)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
  • Troglitazone, >=98% (HPLC)
  • HSCI1_000037
  • 5-[(4-{[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methyl]oxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
441.55 g/molcalc.
Exact mass
441.161 Dacalc.
LogP (octanol/water)
4.37calc.
Topological polar surface area
84.86 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
31calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(=O)C(Cc2ccc(OCC3CCc4ccccc4O3)cc2)S1

O=C1NC(=O)C(Cc2ccc(OCC3CCc4ccccc4O3)cc2)S1

4 rings, 26 atoms.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Troglitazone suppliers

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All 24 suppliers
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Where suppliers are based

24 suppliers in 5 countries

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Troglitazone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Hypoglycemic Agents

Roles

  • anticoagulant
  • anticonvulsant
  • antineoplastic agent
  • antioxidant
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • ferroptosis inhibitor
  • hematologic agent
  • hypoglycemic agent
  • pharmaceutical
  • platelet aggregation inhibitor
  • vasodilator agent

Pharmacology

Troglitazone is an orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Troglitazone is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Troglitazone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Troglitazone, based on the data on this page

What is Troglitazone?

Troglitazone is a member of chromanes and a thiazolidinone. It has a role as a ferroptosis inhibitor, an antioxidant, a hypoglycemic agent, an antineoplastic agent, a vasodilator agent, an anticonvulsant, an anticoagulant, a platelet aggregation inhibitor and an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor.

What is the CAS number of Troglitazone?

The CAS registry number of Troglitazone is 97322-87-7.

What is the molecular formula and weight of Troglitazone?

The molecular formula of Troglitazone is C24H27NO5S and its molar mass is 441.55 g/mol.

What is Troglitazone used for?

Known uses and roles of Troglitazone include building blocks in research and laboratory, screening compounds in research and laboratory, anticoagulant, anticonvulsant, antineoplastic agent and 12 more.

Is Troglitazone hazardous?

No GHS hazard classification for Troglitazone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Troglitazone?

Troglitazone is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Troglitazone?

CompoundList lists 24 suppliers of Troglitazone in United States, China, United Kingdom, Germany and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Troglitazone?

Suppliers quote Troglitazone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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