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Glycosides and other natural products

Tylosin

Also known as Tylosin A, Tylosine, Tilosina

CAS 1401-69-0Formula C46H77NO17Molar mass 916.11 g/molEC 215-754-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 42 suppliers listed Drug substance
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Tylosin chemical structure, C46H77NO17, CAS 1401-69-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from water
Melting point
128 to 132
Solubility
In water, 5 mg/mL at 25 °C
HS code
294190
Category
Glycosides and other natural products
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Tylosin?

Plain description, key identifiers and synonyms

Tylosin is a macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae. It has a role as a xenobiotic, an allergen, a bacterial metabolite and an environmental contaminant. It is an aldehyde, a leucomycin, a macrolide antibiotic, an enone, a disaccharide derivative and a monosaccharide derivative. It is functionally related to a tylactone. It is a conjugate base of a tylosin(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
CAS number
1401-69-0 CAS number cross-checkedOther or deprecated CAS: 1405-54-5, 8026-48-0
EC number
215-754-8
Molecular formula
C46H77NO17
UNII
YEF4JXN031
InChIKey
WBPYTXDJUQJLPQ-VMXQISHHSA-N
InChI
InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1
Canonical SMILES
CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)C=CC(C)=CC1COC1OC(C)C(O)C(OC)C1OC
Isomeric SMILES
CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC

Synonyms

  • Tylosin A
  • Tylosine
  • Tilosina
  • Tylocine
  • Tylan
  • Tylosinum
  • Fradizine
  • Vubityl 200
  • BiloVet
  • Tylosin Base
  • Tartrate, Tylosin
  • Tylan 50
  • Hydrochloride, Tylosin
  • Tylan 200
  • Tylosin Tartrate (Salt)
  • Tylovet 200 mg/mL Injection
  • Tylan 200 Injection, Tylan 50 Injection
  • Tylosin-d3 (100 Mug/mL in Methanol)
  • Tylosin CRS
  • Tylosin (Standard)
  • Tylan (TN)
  • Tylosin A, Fradizine
  • Tylosin (USP/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from waterexp.
Melting point
128 to 132exp.
Solubility
In water, 5 mg/mL at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
916.11 g/molcalc.
Exact mass
915.5192 Dacalc.
LogP (octanol/water)
1.83calc.
Topological polar surface area
238.7 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
18calc.
Rotatable bonds
13calc.
Heavy atoms
64calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.85calc.
Formal charge
0calc.
Stereocentres
21calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC=CC(COC2CCCCO2)COC(=O)CCCC(OC2CCC(OC3CCCCO3)CO2)CCC1

O=C1C=CC=CC(COC2CCCCO2)COC(=O)CCCC(OC2CCC(OC3CCCCO3)CO2)CCC1

4 rings, 40 atoms.

28 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H330Fatal if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H351Suspected of causing cancer.
  • H361dSuspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tylosin suppliers

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All 42 suppliers
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Where suppliers are based

42 suppliers in 11 countries

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Tylosin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anti-Bacterial Agents.

Veterinary medication:.

Veterinary antimicrobial agent also used as prophylactics during surgery or at generally lower levels of administration to promote an animal's ability to withstand pathogenic challenge when under stress.

Used by injection or oral administration to treat Mycoplasma and gram-positive bacterial infections in poultry, swine, and other livestock.

FDA regulated feed additive for chicken and livestock for growth rates and efficiency of gain.

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • aetiopathogenetic role
  • allergen
  • bacterial metabolite
  • environmental contaminant
  • metabolite
  • prokaryotic metabolite
  • xenobiotic

How it is made

Macrolide antibiotic isolated frm a strain of Streptomycetes fradiae found in soil from Thailand.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tylosin is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tylosin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tylosin, based on the data on this page

What is Tylosin?

Tylosin is a macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae. It has a role as a xenobiotic, an allergen, a bacterial metabolite and an environmental contaminant.

What is the CAS number of Tylosin?

The CAS registry number of Tylosin is 1401-69-0. Other or deprecated CAS numbers: 1405-54-5, 8026-48-0.

What is the molecular formula and weight of Tylosin?

The molecular formula of Tylosin is C46H77NO17 and its molar mass is 916.11 g/mol.

What is Tylosin used for?

Anti-Bacterial Agents. Veterinary medication:. Veterinary antimicrobial agent also used as prophylactics during surgery or at generally lower levels of administration to promote an animal's ability to withstand pathogenic challenge when under stress.

Is Tylosin hazardous?

Tylosin carries the GHS signal word "Danger". Main hazards: may cause an allergic skin reaction, causes serious eye irritation, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tylosin?

Tylosin is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tylosin?

CompoundList lists 42 suppliers of Tylosin in China, United States, Germany, United Kingdom and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tylosin in India?

2 suppliers in India list Tylosin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tylosin?

Suppliers quote Tylosin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tylosin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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