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Cardiovascular and metabolic drugs

Vanoxerine

Also known as Gbr 12909, Vanoxerina, Vanoxerinum

CAS 67469-69-6Formula C28H32F2N2OMolar mass 450.57 g/mol
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Vanoxerine chemical structure, C28H32F2N2O, CAS 67469-69-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
67469-69-6
Formula
C28H32F2N2O
Molar mass
450.57 g/mol
HS code
293359
Category
Cardiovascular and metabolic drugs

What is Vanoxerine?

Plain description, key identifiers and synonyms

Vanoxerine is an N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It is an ether, an organofluorine compound, a N-alkylpiperazine and a tertiary amino compound. It is a conjugate base of a vanoxerine(2+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
CAS number
67469-69-6 CAS number cross-checkedOther or deprecated CAS: 110872-73-6
Molecular formula
C28H32F2N2O
UNII
90X28IKH43
InChIKey
NAUWTFJOPJWYOT-UHFFFAOYSA-N
InChI
InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2
SMILES (canonical and isomeric)
C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

Synonyms

  • Gbr 12909
  • Vanoxerina
  • Vanoxerinum
  • Vanoxeamine
  • 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
  • 1-(2-(Bis(p-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
  • 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
  • 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
  • 1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
  • GBR 12909, I893
  • 67469-69-9 (free base)
  • Tocris-0421
  • Biomol-NT_000010
  • Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-
  • DivK1c_006996
  • Sdccgsbi-0050431.p003

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
450.57 g/molcalc.
Exact mass
450.2483 Dacalc.
LogP (octanol/water)
5.32calc.
Topological polar surface area
15.71 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
10calc.
Heavy atoms
33calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCCN2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1

c1ccc(CCCN2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1

4 rings, 31 atoms, the 1-(2-(Diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine ring system.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Vanoxerine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Vanoxerine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Dopamine Uptake Inhibitors

Roles

  • anti-arrhythmia drug
  • cardiovascular drug
  • dopamine uptake inhibitor
  • dopaminergic agent
  • neurotransmitter agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vanoxerine is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vanoxerine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vanoxerine, based on the data on this page

What is Vanoxerine?

Vanoxerine is an N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake).

What is the CAS number of Vanoxerine?

The CAS registry number of Vanoxerine is 67469-69-6. Other or deprecated CAS numbers: 110872-73-6.

What is the molecular formula and weight of Vanoxerine?

The molecular formula of Vanoxerine is C28H32F2N2O and its molar mass is 450.57 g/mol.

What is Vanoxerine used for?

Known uses and roles of Vanoxerine include cardiovascular drugs in pharmaceuticals, cns agents in pharmaceuticals, anti-arrhythmia drug, cardiovascular drug, dopamine uptake inhibitor and 4 more.

Is Vanoxerine hazardous?

No GHS hazard classification for Vanoxerine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Vanoxerine?

Vanoxerine is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vanoxerine?

CompoundList lists 2 suppliers of Vanoxerine in Canada and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Vanoxerine?

Suppliers quote Vanoxerine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vanoxerine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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