CompoundList
Sign in
Screening compounds

Vebreltinib

Also known as Bozitinib, 6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine, Vebreltinib (USAN)

CAS 1440964-89-5Formula C20H15F3N8Molar mass 424.39 g/mol
Get quotes Safety data
Vebreltinib chemical structure, C20H15F3N8, CAS 1440964-89-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1440964-89-5
Formula
C20H15F3N8
Molar mass
424.39 g/mol
HS code
293319
Category
Screening compounds

What is Vebreltinib?

Plain description, key identifiers and synonyms

Vebreltinib is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor, HGFR) with potential antineoplastic activity. Upon administration, vebreltinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
CAS number
1440964-89-5
Molecular formula
C20H15F3N8
UNII
2WZP8A9VFN
MDL number
MFCD32201071
InChIKey
QHXLXUIZUCJRKV-UHFFFAOYSA-N
InChI
InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
SMILES (canonical and isomeric)
CN1C=C2C=C(C(=CC2=N1)F)C(C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C6CC6)(F)F

Synonyms

  • Bozitinib
  • 6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
  • Vebreltinib (USAN)
  • 6-(1-cyclopropylpyrazol-4-yl)-3-(difluoro-(6-fluoro-2-methylindazol-5-yl)methyl)-(1,2,4)triazolo(4,3-b)pyridazine
  • 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-
  • 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine
  • Bozitinib (PLB-1001)
  • 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine
  • 5-{[6-(1-cyclopropyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]difluoromethyl}-6-fluoro-2-methyl-2H-indazole
  • 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6- fluoro-2-methyl-2H-indazol-5-yl)methyl)-
  • 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5- yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine
  • PLB-1001?
  • WHO 11677
  • US9695175, 44
  • PLB-1001, T-101, APL-101, CBI-3103
  • 6-(1-Cyclopropyl-4-pyrazolyl)-3-[difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
  • 6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methyl-indazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
424.39 g/molcalc.
Exact mass
424.1372 Dacalc.
LogP (octanol/water)
3.49calc.
Topological polar surface area
78.72 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
31calc.
Rings
6calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2[nH]ncc2cc1Cc1nnc2ccc(-c3cnn(C4CC4)c3)nn12

c1cc2[nH]ncc2cc1Cc1nnc2ccc(-c3cnn(C4CC4)c3)nn12

6 rings, 27 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Vebreltinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

Post one free request and suppliers who make or trade Vebreltinib can send you quotes. Your contact details stay private until you accept a quote.

Request quotesSell this chemical

Vebreltinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vebreltinib is traded under.

HS 2933.19Indicative HS code

Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.44B
−22.6% vs 2023, imports $6.66B
2019 to 2024
Top exporters
  1. China21.6%
  2. Switzerland * partner reported20.5%
  3. Germany19.0%
Top importers
  1. Slovenia38.4%
  2. Portugal14.1%
  3. Brazil13.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vebreltinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vebreltinib, based on the data on this page

What is Vebreltinib?

Vebreltinib is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor, HGFR) with potential antineoplastic activity. Upon administration, vebreltinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways.

What is the CAS number of Vebreltinib?

The CAS registry number of Vebreltinib is 1440964-89-5.

What is the molecular formula and weight of Vebreltinib?

The molecular formula of Vebreltinib is C20H15F3N8 and its molar mass is 424.39 g/mol.

What is Vebreltinib used for?

Known uses and roles of Vebreltinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Vebreltinib hazardous?

No GHS hazard classification for Vebreltinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Vebreltinib?

Vebreltinib is usually classified under HS code 293319 (Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vebreltinib?

Post a free request on CompoundList and suppliers of Vebreltinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Vebreltinib?

Suppliers quote Vebreltinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vebreltinib

Get quotes for Vebreltinib

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Vebreltinib
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Vebreltinib with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/vebreltinib-1440964-89-5" title="Vebreltinib structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293319

Price on request
Free quotes, contact stays private
Get quotes