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Cardiovascular and metabolic drugs

Verapamil

Also known as Iproveratril, Dilacoran, Verapamilo

CAS 52-53-9Formula C27H38N2O4Molar mass 454.61 g/molEC 200-145-1
GHS signal word: Danger. Pictograms: Serious health hazard 68 suppliers listed Drug substance
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Verapamil chemical structure, C27H38N2O4, CAS 52-53-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Viscous, pale yellow oil
Boiling point
245 °C
Solubility
Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190…
HS code
292690
Category
Cardiovascular and metabolic drugs
Illustrative photo, amber viscous liquid in an open pail in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Verapamil?

Plain description, key identifiers and synonyms

2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile is a tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. It is a nitrile, an aromatic ether, a polyether and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
CAS number
52-53-9 CAS number cross-checkedOther or deprecated CAS: 36622-29-4, 56949-77-0
EC numbers
200-145-1, 253-133-3, 260-462-6
Molecular formula
C27H38N2O4
UNII
CJ0O37KU29
MDL number
MFCD00056240
InChIKey
SGTNSNPWRIOYBX-UHFFFAOYSA-N
InChI
InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
SMILES (canonical and isomeric)
CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC

Synonyms

  • Iproveratril
  • Dilacoran
  • Verapamilo
  • Cardibeltin
  • Verapamilum
  • Isoptine
  • Securon
  • Cardiagutt
  • Dignover
  • Veramex
  • Verpamil
  • Quasar
  • dl-Verapamil
  • Novo-Veramil
  • r,s-verapamil
  • Apo-Verap
  • Nu-Verap
  • 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
  • Manidon
  • 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
  • Verapamil slow release
  • Cardiabeltin
  • Cardioprotect
  • Durasoptin
  • Hexasoptin
Show all 39 synonyms
  • Veroptinstada
  • Calaptin
  • Caveril
  • Civicor
  • Coraver
  • Corpamil
  • Harteze
  • Hormitol
  • Ikapress
  • Inselon
  • Isoptino
  • Jenapamil
  • Lodixal
  • Magotiron

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Viscous, pale yellow oilexp.
Boiling point
245 °Cexp.
Solubility
Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190 proof) >100, methanol >100, 2-propanol 4.6, ethyl acetate 1.0, DMF >100, methylene chloride >100, hexane 0.001, Freely soluble in chloroform…exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
454.61 g/molcalc.
Exact mass
454.2832 Dacalc.
LogP (octanol/water)
5.09calc.
Topological polar surface area
63.95 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
13calc.
Heavy atoms
33calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCCCNCCc2ccccc2)cc1

c1ccc(CCCCNCCc2ccccc2)cc1

2 rings, 19 atoms.

93 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H331Toxic if inhaled.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Verapamil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 68 suppliers
30 of 30 offers
  • Snap Intermediates
    India, MumbaiUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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  • 001Chemical
    China, HangzhouUnclaimed profile
    VerapamilGrade, purity and minimum order on request
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  • 10X Chem
    United States, San DiegoUnclaimed profile
    VerapamilGrade, purity and minimum order on request
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  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    VerapamilGrade, purity and minimum order on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    VerapamilGrade, purity and minimum order on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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  • ABCR GmbH & CO. KG
    GermanyUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    VerapamilGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

68 suppliers in 12 countries

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Verapamil price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anti-Arrhythmia Agents, Calcium Channel Blockers, Vasodilator Agents.

Use classes: Pharmaceuticals, Cardiovascular system.

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Calcium Channel Blockers
  • Vasodilator Agents

Pharmacology

Verapamil is a Calcium Channel Blocker. The mechanism of action of verapamil is as a Calcium Channel Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor.

How it is made

Preparation: Belgium patent 615861, Dengel, United States of America patent 3261859 (1962, 1966 both to Knoll).

Veratryl chloride + isopropyl bromide + homoveratrylamine + 1-bromo-3-chloroporpane (dehydrobromination/methylation/amine formation/dehydrochlorination)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Verapamil is traded under.

HS 2926.90Indicative HS code

Nitrile-function compounds, other

World exports in 2024
$2.15B
−13.5% vs 2023, imports $2.17B
2019 to 2024
Top exporters
  1. China35.6%
  2. France * partner reported12.7%
  3. India * partner reported11.2%
Top importers
  1. United States13.6%
  2. China12.4%
  3. Brazil11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Verapamil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Verapamil, based on the data on this page

What is Verapamil?

2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile is a tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

What is the CAS number of Verapamil?

The CAS registry number of Verapamil is 52-53-9. Other or deprecated CAS numbers: 36622-29-4, 56949-77-0.

What is the molecular formula and weight of Verapamil?

The molecular formula of Verapamil is C27H38N2O4 and its molar mass is 454.61 g/mol.

What is Verapamil used for?

Anti-Arrhythmia Agents, Calcium Channel Blockers, Vasodilator Agents. Use classes: Pharmaceuticals, Cardiovascular system.

Is Verapamil hazardous?

Verapamil carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin, toxic if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Verapamil?

Verapamil is usually classified under HS code 292690 (Nitrile-function compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Verapamil?

CompoundList lists 68 suppliers of Verapamil in United States, China, Germany, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Verapamil in India?

1 supplier in India list Verapamil on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Verapamil?

Suppliers quote Verapamil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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