CompoundList
Sign in
Heterocyclic building blocks

Ziftomenib

Also known as Ko 539, compound 151, Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539

CAS 2134675-36-6Formula C33H42F3N9O2S2Molar mass 717.89 g/mol
1 supplier listed
Get quotes See the supplier
Ziftomenib chemical structure, C33H42F3N9O2S2, CAS 2134675-36-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2134675-36-6
Formula
C33H42F3N9O2S2
Molar mass
717.89 g/mol
HS code
293590
Category
Heterocyclic building blocks

What is Ziftomenib?

Plain description, key identifiers and synonyms

Ziftomenib is an orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL, myeloid/lymphoid leukemia, KMT2A) fusion protein, with potential antineoplastic activity. Upon oral administration, ziftomenib prevents the interaction between the two proteins menin and MLL, and thus the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth and proliferation of certain kinds of leukemia cells.

Ziftomenib is a pharmaceutical compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1-[(2S)-2-(4-methylsulfonylpiperazin-1-yl)propyl]indole-2-carbonitrile
CAS number
2134675-36-6
Molecular formula
C33H42F3N9O2S2
UNII
4MOD1F4ENC
MDL number
MFCD34574446
InChIKey
BGGALFIXXQOTPY-NRFANRHFSA-N
InChI
InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1
Canonical SMILES
CNc1nc(NC2CCN(Cc3ccc4c(cc(C#N)n4CC(C)N4CCN(S(C)(=O)=O)CC4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1
Isomeric SMILES
CC1=C(C=CC2=C1C=C(N2C[C@H](C)N3CCN(CC3)S(=O)(=O)C)C#N)CN4CCC(CC4)NC5=C6C=C(SC6=NC(=N5)NC)CC(F)(F)F

Synonyms

  • Ko 539
  • compound 151
  • Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539
  • compound 151 (US10781218B2)
  • Menin-MLL Inhibitor KO-539
  • Menin-KMT2A Inhibitor KO 539
  • Komzifti
  • WHO 11651
  • Menin-mll interaction inhibitor KO 539
  • Komzifti (TN)
  • KO-539, ziftomenibum
  • Ziftomenib (USAN/INN)
  • 1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
717.89 g/molcalc.
Exact mass
717.2855 Dacalc.
LogP (octanol/water)
5.01calc.
Topological polar surface area
122.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
10calc.
Heavy atoms
49calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.55calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1nc(NC2CCN(Cc3ccc4c(ccn4CCN4CCNCC4)c3)CC2)c2ccsc2n1

c1nc(NC2CCN(Cc3ccc4c(ccn4CCN4CCNCC4)c3)CC2)c2ccsc2n1

6 rings, 34 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ziftomenib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

See the supplier
  • Axon Medchem
    United States, RestonUnclaimed profile
    ZiftomenibGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Ziftomenib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Ziftomenib is a Menin Inhibitor. The mechanism of action of ziftomenib is as a Menin Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ziftomenib is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ziftomenib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ziftomenib, based on the data on this page

What is Ziftomenib?

Ziftomenib is an orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL, myeloid/lymphoid leukemia, KMT2A) fusion protein, with potential antineoplastic activity.

What is the CAS number of Ziftomenib?

The CAS registry number of Ziftomenib is 2134675-36-6.

What is the molecular formula and weight of Ziftomenib?

The molecular formula of Ziftomenib is C33H42F3N9O2S2 and its molar mass is 717.89 g/mol.

What is Ziftomenib used for?

Known uses and roles of Ziftomenib include building blocks in research and laboratory, antineoplastic agent and pharmaceutical.

Is Ziftomenib hazardous?

No GHS hazard classification for Ziftomenib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ziftomenib?

Ziftomenib is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ziftomenib?

CompoundList lists 1 supplier of Ziftomenib in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ziftomenib?

Suppliers quote Ziftomenib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ziftomenib

Get quotes for Ziftomenib

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Ziftomenib
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Ziftomenib with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/ziftomenib-2134675-36-6" title="Ziftomenib structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Heterocyclic building blocks or HS code 293590

1 supplier
Free quotes, contact stays private
Get quotes