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Analgesics and anti-inflammatories

Zileuton

Also known as Zyflo, Leutrol, Zyflo CR

CAS 111406-87-2Formula C11H12N2O2SMolar mass 236.30 g/molEC 601-087-3
GHS signal word: Warning. Pictograms: Harmful or irritant 95 suppliers listed Drug substance
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Zileuton chemical structure, C11H12N2O2S, CAS 111406-87-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
111406-87-2
Formula
C11H12N2O2S
Molar mass
236.30 g/mol
EC number
601-087-3
HS code
293499
Category
Analgesics and anti-inflammatories

What is Zileuton?

Plain description, key identifiers and synonyms

Zileuton is a member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. It has a role as a ferroptosis inhibitor, a non-steroidal anti-inflammatory drug, a leukotriene antagonist, an anti-asthmatic drug and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of 1-benzothiophenes and a member of ureas. It derives from a hydride of a 1-benzothiophene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
CAS number
111406-87-2 CAS number cross-checked
EC number
601-087-3
Molecular formula
C11H12N2O2S
UNII
V1L22WVE2S
MDL number
MFCD00866097
InChIKey
MWLSOWXNZPKENC-UHFFFAOYSA-N
InChI
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
SMILES (canonical and isomeric)
CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O

Synonyms

  • Zyflo
  • Leutrol
  • Zyflo CR
  • Zileutonum
  • 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
  • N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
  • (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea
  • N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
  • n-(1-benzo[b]thien-2-ylethyl)-n-hydroxyurea
  • (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
  • Abbot 64077
  • 1-(1-(1-benzothiophen-2-yl)ethyl)-1-hydroxyurea
  • N-(1-(benzo(b)thiophen-2-yl)ethyl)-N-hydroxyurea
  • (+-)-N-Hydroxy-N-(1-benzo(b)thien-2-ylethyl)-urea
  • 1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea
  • Abbott 64077
  • Zyflo (TN)
  • Urea, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-
  • 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
  • (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
  • N-(1-Benzo(b)thien-2-yl-ethyl)-N-hydroxyurea
  • Urea, N-(1-benzo(b)thien-2-ylethyl)-N-hydroxy-
  • Ziluton
  • Zyflo Filmtab
  • Zileuton (USP/INN)
Show all 30 synonyms
  • (+/-)-1-(1-benzo(b)thien-2-ylethyl)-1-hydroxyurea
  • Leutrol,
  • ( inverted exclamation markA)-1(1-Benzo[b]thien-2-ylethyl)-1-hydroxyure
  • Zyflo,
  • Zileuton (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
236.30 g/molcalc.
Exact mass
236.0619 Dacalc.
LogP (octanol/water)
2.73calc.
Topological polar surface area
66.56 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.18calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2sccc2c1

c1ccc2sccc2c1

2 rings, 9 atoms, the Benzo(B)thiophene ring system.

4,889 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Zileuton suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 95 suppliers
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Where suppliers are based

95 suppliers in 16 countries

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Zileuton price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Leukotriene Antagonists
  • Lipoxygenase Inhibitors

Roles

  • antagonist
  • anti-anaemic agent
  • anti-asthmatic agent
  • anti-asthmatic drug
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antifibrotic agent
  • antineoplastic agent
  • antirheumatic drug
  • enzyme inhibitor
  • ferroptosis inhibitor
  • hormone antagonist
  • hormone receptor modulator
  • leukotriene antagonist
  • lipoxygenase inhibitor
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • receptor modulator

Pharmacology

Zileuton is a 5-Lipoxygenase Inhibitor. The mechanism of action of zileuton is as a 5-Lipoxygenase Inhibitor. The physiologic effect of zileuton is by means of Decreased Leukotriene Production.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Zileuton is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Zileuton is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Zileuton, based on the data on this page

What is Zileuton?

Zileuton is a member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4.

What is the CAS number of Zileuton?

The CAS registry number of Zileuton is 111406-87-2.

What is the molecular formula and weight of Zileuton?

The molecular formula of Zileuton is C11H12N2O2S and its molar mass is 236.30 g/mol.

What is Zileuton used for?

Known uses and roles of Zileuton include anti-inflammatories in pharmaceuticals, respiratory and anti-allergy drugs in pharmaceuticals, antagonist, anti-anaemic agent, anti-asthmatic agent and 18 more.

Is Zileuton hazardous?

Zileuton carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Zileuton?

Zileuton is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Zileuton?

CompoundList lists 95 suppliers of Zileuton in United States, China, India, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Zileuton in India?

9 suppliers in India list Zileuton on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Zileuton?

Suppliers quote Zileuton on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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