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Murcko scaffold

Ring system with 4 rings and 27 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
32
With full pages
5
Scaffold SMILES

O=C(Cc1coc2ccccc12)N(Cc1ccccc1)C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1coc2ccccc12)N(Cc1ccccc1)C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide chemical structure, C25H29NO4S, CAS 831241-10-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide
CAS 831241-10-2C25H29NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide chemical structure, C24H26FNO4S, CAS 880401-46-7
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide
CAS 880401-46-7C24H26FNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C23H25NO5S, CAS 880793-66-8
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880793-66-8C23H25NO5S
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H22ClNO4S, CAS 880404-73-9
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880404-73-9C22H22ClNO4S
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H22ClNO4S, CAS 880793-60-2
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880793-60-2C22H22ClNO4S
N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(6-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H22ClNO4S, CAS 872867-54-4
N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(6-methyl-1-benzofuran-3-yl)acetamide
CAS 872867-54-4C22H22ClNO4S
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)acetamide chemical structure, C23H25NO4S, CAS 873681-60-8
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)acetamide
CAS 873681-60-8C23H25NO4S
N-Benzyl-2-(4,6-dimethyl-1-benzofuran-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C23H25NO4S, CAS 880789-81-1
N-Benzyl-2-(4,6-dimethyl-1-benzofuran-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 880789-81-1C23H25NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H22FNO4S, CAS 880401-81-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880401-81-0C22H22FNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]-N-[4-(propan-2-yl)benzyl]acetamide chemical structure, C27H33NO4S, CAS 880401-86-5
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]-N-[4-(propan-2-yl)benzyl]acetamide
CAS 880401-86-5C27H33NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-(4-methylbenzyl)acetamide chemical structure, C23H25NO4S, CAS 880401-91-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-(4-methylbenzyl)acetamide
CAS 880401-91-2C23H25NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methylbenzyl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide chemical structure, C25H29NO4S, CAS 880401-96-7
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methylbenzyl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide
CAS 880401-96-7C25H29NO4S
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide chemical structure, C24H26ClNO4S, CAS 880402-01-7
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-[5-(propan-2-yl)-1-benzofuran-3-yl]acetamide
CAS 880402-01-7C24H26ClNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C24H27NO5S, CAS 880402-30-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880402-30-2C24H27NO5S
N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H22ClNO4S, CAS 880404-61-5
N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880404-61-5C22H22ClNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-(4-propoxybenzyl)acetamide chemical structure, C25H29NO5S, CAS 880404-65-9
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)-N-(4-propoxybenzyl)acetamide
CAS 880404-65-9C25H29NO5S
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C22H23NO4S, CAS 880404-85-3
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880404-85-3C22H23NO4S
2-(4,6-Dimethyl-1-benzofuran-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide chemical structure, C26H31NO4S, CAS 880787-17-7
2-(4,6-Dimethyl-1-benzofuran-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide
CAS 880787-17-7C26H31NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide chemical structure, C24H27NO4S, CAS 880793-62-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-2-(5-methyl-1-benzofuran-3-yl)acetamide
CAS 880793-62-4C24H27NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-2-(5-ethyl-1-benzofuran-3-yl)acetamide chemical structure, C25H29NO5S, CAS 866247-46-3
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-2-(5-ethyl-1-benzofuran-3-yl)acetamide
CAS 866247-46-3C25H29NO5S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-methoxybenzyl)acetamide chemical structure, C24H27NO5S, CAS 866247-47-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-methoxybenzyl)acetamide
CAS 866247-47-4C24H27NO5S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-ethylbenzyl)acetamide chemical structure, C25H29NO4S, CAS 866247-48-5
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-ethylbenzyl)acetamide
CAS 866247-48-5C25H29NO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-fluorobenzyl)acetamide chemical structure, C23H24FNO4S, CAS 866247-49-6
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-fluorobenzyl)acetamide
CAS 866247-49-6C23H24FNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-methylbenzyl)acetamide chemical structure, C24H27NO4S, CAS 866247-50-9
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(5-ethyl-1-benzofuran-3-yl)-N-(4-methylbenzyl)acetamide
CAS 866247-50-9C24H27NO4S