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Murcko scaffold

Ring system with 4 rings and 24 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
13
With full pages
6
Scaffold SMILES

O=C1CSC(c2ccccc2)N1c1c[nH]n(-c2ccccc2)c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CSC(c2ccccc2)N1c1c[nH]n(-c2ccccc2)c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenyl-1,3-thiazolidin-4-one chemical structure, C20H19N3O2S, CAS 125298-50-2
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenyl-1,3-thiazolidin-4-one
CAS 125298-50-2C20H19N3O2S
3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-hydroxy-3-methoxyphenyl)-1,3-thiazolidin-4-one chemical structure, C21H21N3O4S, CAS 302549-05-9
3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-hydroxy-3-methoxyphenyl)-1,3-thiazolidin-4-one
CAS 302549-05-9C21H21N3O4S
2-(2-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-thiazolidin-4-one chemical structure, C20H18ClN3O2S, CAS 128317-46-4
2-(2-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-thiazolidin-4-one
CAS 128317-46-4C20H18ClN3O2S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one chemical structure, C21H21N3O3S, CAS 125298-58-0
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one
CAS 125298-58-0C21H21N3O3S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-ethoxyphenyl)-1,3-thiazolidin-4-one chemical structure, C22H23N3O3S, CAS 313391-90-1
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-ethoxyphenyl)-1,3-thiazolidin-4-one
CAS 313391-90-1C22H23N3O3S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one chemical structure, C20H18FN3O2S, CAS 128317-50-0
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one
CAS 128317-50-0C20H18FN3O2S
2-(3,4-Dimethoxyphenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-thiazolidin-4-one chemical structure, C22H23N3O4S, CAS 302549-04-8
2-(3,4-Dimethoxyphenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-thiazolidin-4-one
CAS 302549-04-8C22H23N3O4S
2-(3-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1,3-thiazolidin-4-one chemical structure, C21H20ClN3O2S, CAS 923554-15-8
2-(3-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1,3-thiazolidin-4-one
CAS 923554-15-8C21H20ClN3O2S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-methoxyphenyl)-5-methyl-1,3-thiazolidin-4-one chemical structure, C22H23N3O3S, CAS 923554-18-1
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-methoxyphenyl)-5-methyl-1,3-thiazolidin-4-one
CAS 923554-18-1C22H23N3O3S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(3-methoxyphenyl)-5-methyl-1,3-thiazolidin-4-one chemical structure, C22H23N3O3S, CAS 923554-20-5
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(3-methoxyphenyl)-5-methyl-1,3-thiazolidin-4-one
CAS 923554-20-5C22H23N3O3S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-2-(3,4,5-trimethoxyphenyl)-1,3-thiazolidin-4-one chemical structure, C24H27N3O5S, CAS 923554-22-7
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-2-(3,4,5-trimethoxyphenyl)-1,3-thiazolidin-4-one
CAS 923554-22-7C24H27N3O5S
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-2-(4-methylphenyl)-1,3-thiazolidin-4-one chemical structure, C22H23N3O2S, CAS 142821-71-4
3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-2-(4-methylphenyl)-1,3-thiazolidin-4-one
CAS 142821-71-4C22H23N3O2S
2-(2-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1,3-thiazolidin-4-one chemical structure, C21H20ClN3O2S, CAS 142821-72-5
2-(2-Chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1,3-thiazolidin-4-one
CAS 142821-72-5C21H20ClN3O2S