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Murcko scaffold

Ring system with 4 rings and 30 atoms

27 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
30
Chemicals
27
With full pages
3
Scaffold SMILES

O=C(Nc1ccccc1)Nc1nc(CC(=O)N2CCN(c3ccccc3)CC2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1nc(CC(=O)N2CCN(c3ccccc3)CC2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

1-(2-Methoxyphenyl)-3-{4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1,3-thiazol-2-yl}urea chemical structure, C23H25N5O3S, CAS 897621-68-0
1-(2-Methoxyphenyl)-3-{4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1,3-thiazol-2-yl}urea
CAS 897621-68-0C23H25N5O3S
1-[4-[2-Keto-2-[4-(4-methoxyphenyl)piperazino]ethyl]thiazol-2-yl]-3-(2-methoxyphenyl)urea chemical structure, C24H27N5O4S, CAS 897621-78-2
1-[4-[2-Keto-2-[4-(4-methoxyphenyl)piperazino]ethyl]thiazol-2-yl]-3-(2-methoxyphenyl)urea
CAS 897621-78-2C24H27N5O4S
1-(2-Methoxyphenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C24H27N5O4S, CAS 897621-80-6
1-(2-Methoxyphenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-80-6C24H27N5O4S
1-(4-Chlorophenyl)-3-(4-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)thiazol-2-yl)urea chemical structure, C22H22ClN5O2S, CAS 897620-72-3
1-(4-Chlorophenyl)-3-(4-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)thiazol-2-yl)urea
CAS 897620-72-3C22H22ClN5O2S
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21Cl2N5O2S, CAS 897620-74-5
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-74-5C22H21Cl2N5O2S
1-(4-Chlorophenyl)-3-(4-(2-(4-(3-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21Cl2N5O2S, CAS 897620-75-6
1-(4-Chlorophenyl)-3-(4-(2-(4-(3-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-75-6C22H21Cl2N5O2S
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21ClFN5O2S, CAS 897620-76-7
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-76-7C22H21ClFN5O2S
1-(4-Chlorophenyl)-3-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21ClFN5O2S, CAS 897620-77-8
1-(4-Chlorophenyl)-3-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-77-8C22H21ClFN5O2S
1-(4-Chlorophenyl)-3-(4-(2-(4-(4-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C23H24ClN5O3S, CAS 897620-78-9
1-(4-Chlorophenyl)-3-(4-(2-(4-(4-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-78-9C23H24ClN5O3S
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C23H24ClN5O3S, CAS 897620-79-0
1-(4-Chlorophenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897620-79-0C23H24ClN5O3S
1-(3-Chlorophenyl)-3-(4-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)thiazol-2-yl)urea chemical structure, C22H22ClN5O2S, CAS 897621-01-1
1-(3-Chlorophenyl)-3-(4-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)thiazol-2-yl)urea
CAS 897621-01-1C22H22ClN5O2S
1-(3-Chlorophenyl)-3-(4-(2-(4-(2-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21Cl2N5O2S, CAS 897621-02-2
1-(3-Chlorophenyl)-3-(4-(2-(4-(2-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-02-2C22H21Cl2N5O2S
1-(3-Chlorophenyl)-3-(4-(2-(4-(3-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21Cl2N5O2S, CAS 897621-04-4
1-(3-Chlorophenyl)-3-(4-(2-(4-(3-chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-04-4C22H21Cl2N5O2S
1-(3-Chlorophenyl)-3-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C22H21ClFN5O2S, CAS 897621-06-6
1-(3-Chlorophenyl)-3-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-06-6C22H21ClFN5O2S
1-(3-Chlorophenyl)-3-(4-(2-(4-(4-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C23H24ClN5O3S, CAS 897621-08-8
1-(3-Chlorophenyl)-3-(4-(2-(4-(4-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-08-8C23H24ClN5O3S
1-(3-Chlorophenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea chemical structure, C23H24ClN5O3S, CAS 897621-10-2
1-(3-Chlorophenyl)-3-(4-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)urea
CAS 897621-10-2C23H24ClN5O3S
1-(4-(2-(4-(2-Chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea chemical structure, C23H24ClN5O3S, CAS 897621-72-6
1-(4-(2-(4-(2-Chlorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea
CAS 897621-72-6C23H24ClN5O3S
1-(4-(2-(4-(2-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea chemical structure, C23H24FN5O3S, CAS 897621-74-8
1-(4-(2-(4-(2-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea
CAS 897621-74-8C23H24FN5O3S
1-(4-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea chemical structure, C23H24FN5O3S, CAS 897621-76-0
1-(4-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)thiazol-2-yl)-3-(2-methoxyphenyl)urea
CAS 897621-76-0C23H24FN5O3S
1-(4-(2-Oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)-3-phenylurea chemical structure, C23H22F3N5O2S, CAS 923678-70-0
1-(4-(2-Oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)-3-phenylurea
CAS 923678-70-0C23H22F3N5O2S
1-(4-(2-Oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)-3-(p-tolyl)urea chemical structure, C24H24F3N5O2S, CAS 923191-88-2
1-(4-(2-Oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)-3-(p-tolyl)urea
CAS 923191-88-2C24H24F3N5O2S
1-(3-Chlorophenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea chemical structure, C23H21ClF3N5O2S, CAS 923244-29-5
1-(3-Chlorophenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea
CAS 923244-29-5C23H21ClF3N5O2S
1-(4-Chlorophenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea chemical structure, C23H21ClF3N5O2S, CAS 923192-52-3
1-(4-Chlorophenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea
CAS 923192-52-3C23H21ClF3N5O2S
1-(2-Methoxyphenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea chemical structure, C24H24F3N5O3S, CAS 923244-41-1
1-(2-Methoxyphenyl)-3-(4-(2-oxo-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)thiazol-2-yl)urea
CAS 923244-41-1C24H24F3N5O3S