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Murcko scaffold

2-Benzyl-5-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one scaffold

42 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 42
With full pages: 3

Scaffold SMILES

O=C1c2cccc(OCc3ccccc3)c2CCN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-Benzyl-5-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one page

Murcko scaffold O=C1c2cccc(OCc3ccccc3)c2CCN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

2-[(4-Bromophenyl)methyl]-5-phenylmethoxy-3,4-dihydroisoquinolin-1-one chemical structure, C23H20BrNO2, CAS 850904-10-8

2-[(4-Bromophenyl)methyl]-5-phenylmethoxy-3,4-dihydroisoquinolin-1-one

CAS 850904-10-8C₂₃H₂₀BrNO₂

2-(4-Bromobenzyl)-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19BrClNO2, CAS 850904-12-0

2-(4-Bromobenzyl)-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850904-12-0C₂₃H₁₉BrClNO₂

2-(4-Bromobenzyl)-5-((4-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19BrClNO2, CAS 850904-13-1

2-(4-Bromobenzyl)-5-((4-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850904-13-1C₂₃H₁₉BrClNO₂

2-Benzyl-5-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H21NO2, CAS 850905-30-5

2-Benzyl-5-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-30-5C₂₃H₂₁NO₂

2-Benzyl-5-((4-fluorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H20FNO2, CAS 850905-31-6

2-Benzyl-5-((4-fluorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-31-6C₂₃H₂₀FNO₂

2-Benzyl-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H23NO2, CAS 850905-32-7

2-Benzyl-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-32-7C₂₄H₂₃NO₂

2-Benzyl-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H20ClNO2, CAS 850905-33-8

2-Benzyl-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-33-8C₂₃H₂₀ClNO₂

2-Benzyl-5-[(4-chlorophenyl)methoxy]-3,4-dihydroisoquinolin-1-one chemical structure, C23H20ClNO2, CAS 850905-34-9

2-Benzyl-5-[(4-chlorophenyl)methoxy]-3,4-dihydroisoquinolin-1-one

CAS 850905-34-9C₂₃H₂₀ClNO₂

5-(Benzyloxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H20FNO2, CAS 850905-74-7

5-(Benzyloxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-74-7C₂₃H₂₀FNO₂

5-[(4-Fluorophenyl)methoxy]-2-[(4-fluorophenyl)methyl]-3,4-dihydroisoquinolin-1-one chemical structure, C23H19F2NO2, CAS 850905-75-8

5-[(4-Fluorophenyl)methoxy]-2-[(4-fluorophenyl)methyl]-3,4-dihydroisoquinolin-1-one

CAS 850905-75-8C₂₃H₁₉F₂NO₂

2-[(4-Fluorophenyl)methyl]-5-[(4-methylphenyl)methoxy]-3,4-dihydroisoquinolin-1-one chemical structure, C24H22FNO2, CAS 850905-76-9

2-[(4-Fluorophenyl)methyl]-5-[(4-methylphenyl)methoxy]-3,4-dihydroisoquinolin-1-one

CAS 850905-76-9C₂₄H₂₂FNO₂

5-((2-Chlorobenzyl)oxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19ClFNO2, CAS 850905-77-0

5-((2-Chlorobenzyl)oxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-77-0C₂₃H₁₉ClFNO₂

5-((4-Chlorobenzyl)oxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19ClFNO2, CAS 850905-78-1

5-((4-Chlorobenzyl)oxy)-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850905-78-1C₂₃H₁₉ClFNO₂

5-(Benzyloxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H23NO2, CAS 850906-12-6

5-(Benzyloxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-12-6C₂₄H₂₃NO₂

5-((4-Fluorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H22FNO2, CAS 850906-13-7

5-((4-Fluorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-13-7C₂₄H₂₂FNO₂

2-(4-Methylbenzyl)-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C25H25NO2, CAS 850906-14-8

2-(4-Methylbenzyl)-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-14-8C₂₅H₂₅NO₂

5-((2-Chlorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H22ClNO2, CAS 850906-15-9

5-((2-Chlorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-15-9C₂₄H₂₂ClNO₂

5-((4-Chlorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H22ClNO2, CAS 850906-16-0

5-((4-Chlorobenzyl)oxy)-2-(4-methylbenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-16-0C₂₄H₂₂ClNO₂

2-[(4-Chlorophenyl)methyl]-5-phenylmethoxy-3,4-dihydroisoquinolin-1-one chemical structure, C23H20ClNO2, CAS 850906-45-5

2-[(4-Chlorophenyl)methyl]-5-phenylmethoxy-3,4-dihydroisoquinolin-1-one

CAS 850906-45-5C₂₃H₂₀ClNO₂

2-(4-Chlorobenzyl)-5-((4-fluorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19ClFNO2, CAS 850906-46-6

2-(4-Chlorobenzyl)-5-((4-fluorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-46-6C₂₃H₁₉ClFNO₂

2-(4-Chlorobenzyl)-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C24H22ClNO2, CAS 850906-47-7

2-(4-Chlorobenzyl)-5-((4-methylbenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-47-7C₂₄H₂₂ClNO₂

2-(4-Chlorobenzyl)-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19Cl2NO2, CAS 850906-48-8

2-(4-Chlorobenzyl)-5-((2-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-48-8C₂₃H₁₉Cl₂NO₂

2-(4-Chlorobenzyl)-5-((4-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H19Cl2NO2, CAS 850906-49-9

2-(4-Chlorobenzyl)-5-((4-chlorobenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-49-9C₂₃H₁₉Cl₂NO₂

5-(Benzyloxy)-2-(2-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C23H20FNO2, CAS 850906-88-6

5-(Benzyloxy)-2-(2-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one

CAS 850906-88-6C₂₃H₂₀FNO₂