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Murcko scaffold

6-[[5-(2-Oxo-2-piperidin-1-ylethyl)sulfanyl-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione scaffold

16 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 30
Chemicals: 16
With full pages: 7

Scaffold SMILES

O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccccc1)N1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 6-[[5-(2-Oxo-2-piperidin-1-ylethyl)sulfanyl-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione page

Murcko scaffold O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccccc1)N1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

6-[[4-(3-Methoxyphenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C22H26N6O4S, CAS 852048-83-0

6-[[4-(3-Methoxyphenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852048-83-0C₂₂H₂₆N₆O₄S

6-((4-(4-Chlorophenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H23ClN6O3S, CAS 852154-69-9

6-((4-(4-Chlorophenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852154-69-9C₂₁H₂₃ClN₆O₃S

6-((4-(2,5-Dimethylphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H26N6O3S, CAS 852048-13-6

6-((4-(2,5-Dimethylphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852048-13-6C₂₂H₂₆N₆O₃S

6-[[4-(4-Ethoxyphenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C23H28N6O4S, CAS 852153-47-0

6-[[4-(4-Ethoxyphenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852153-47-0C₂₃H₂₈N₆O₄S

6-[[4-(4-Fluorophenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H23FN6O3S, CAS 852153-97-0

6-[[4-(4-Fluorophenyl)-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852153-97-0C₂₁H₂₃FN₆O₃S

6-((5-((2-(4-Methylpiperidin-1-yl)-2-oxoethyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H26N6O3S, CAS 852047-41-7

6-((5-((2-(4-Methylpiperidin-1-yl)-2-oxoethyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852047-41-7C₂₂H₂₆N₆O₃S

6-((4-(4-Chlorophenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C20H21ClN6O3S, CAS 852154-66-6

6-((4-(4-Chlorophenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852154-66-6C₂₀H₂₁ClN₆O₃S

6-((5-((2-(4-Methylpiperidin-1-yl)-2-oxoethyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H24N6O3S, CAS 852046-55-0

6-((5-((2-(4-Methylpiperidin-1-yl)-2-oxoethyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852046-55-0C₂₁H₂₄N₆O₃S

6-((4-(4-Fluorophenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C20H21FN6O3S, CAS 852153-94-7

6-((4-(4-Fluorophenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852153-94-7C₂₀H₂₁FN₆O₃S

6-((4-(3-Methoxyphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H24N6O4S, CAS 852048-80-7

6-((4-(3-Methoxyphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852048-80-7C₂₁H₂₄N₆O₄S

6-((4-(2,5-Dimethylphenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C23H28N6O3S, CAS 852048-17-0

6-((4-(2,5-Dimethylphenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852048-17-0C₂₃H₂₈N₆O₃S

6-((4-(4-Methoxyphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H24N6O4S, CAS 852152-81-9

6-((4-(4-Methoxyphenyl)-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852152-81-9C₂₁H₂₄N₆O₄S

6-[[5-(2-Oxo-2-piperidin-1-ylethyl)sulfanyl-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C20H22N6O3S, CAS 852046-52-7

6-[[5-(2-Oxo-2-piperidin-1-ylethyl)sulfanyl-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852046-52-7C₂₀H₂₂N₆O₃S

6-((4-(4-Methoxyphenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H26N6O4S, CAS 852152-84-2

6-((4-(4-Methoxyphenyl)-5-((2-(4-methylpiperidin-1-yl)-2-oxoethyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS 852152-84-2C₂₂H₂₆N₆O₄S

6-[[4-(3-Methylphenyl)-5-(2-oxo-2-piperidin-1-ylethyl)sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H24N6O3S, CAS 852047-38-2

6-[[4-(3-Methylphenyl)-5-(2-oxo-2-piperidin-1-ylethyl)sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852047-38-2C₂₁H₂₄N₆O₃S

6-[[4-(4-Ethoxyphenyl)-5-(2-oxo-2-piperidin-1-ylethyl)sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C22H26N6O4S, CAS 852153-44-7

6-[[4-(4-Ethoxyphenyl)-5-(2-oxo-2-piperidin-1-ylethyl)sulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione

CAS 852153-44-7C₂₂H₂₆N₆O₄S