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Murcko scaffold

Ring system with 4 rings and 29 atoms

16 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 29
Chemicals: 16
With full pages: 4

Scaffold SMILES

O=C1C(=O)N(CCCN2CCOCC2)C(c2ccncc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=O)N(CCCN2CCOCC2)C(c2ccncc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-Hydroxy-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H35N3O5

3-Hydroxy-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₈H₃₅N₃O₅

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O5

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₅H₂₉N₃O₅

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H33N3O5

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₇H₃₃N₃O₅

4-Benzoyl-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H25N3O4, CAS 381712-91-0

4-Benzoyl-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 381712-91-0C₂₃H₂₅N₃O₄

3-Hydroxy-4-(4-methylbenzoyl)-1-(3-(4-morpholinyl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H27N3O4, CAS 381199-47-9

3-Hydroxy-4-(4-methylbenzoyl)-1-(3-(4-morpholinyl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 381199-47-9C₂₄H₂₇N₃O₄

4-(4-Chlorobenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H24ClN3O4, CAS 380564-89-6

4-(4-Chlorobenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 380564-89-6C₂₃H₂₄ClN₃O₄

3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C26H31N3O5, CAS 384369-68-0

3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 384369-68-0C₂₆H₃₁N₃O₅

(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C26H29N3O5, CAS 615271-65-3

(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

CAS 615271-65-3C₂₆H₂₉N₃O₅

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O4, CAS 537686-24-1

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 537686-24-1C₂₅H₂₉N₃O₄

(4E)-4-{Hydroxy[2-methyl-4-(2-methylpropoxy)phenyl]methylidene}-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)pyrrolidine-2,3-dione chemical structure, C28H35N3O5, CAS 488810-38-4

(4E)-4-{Hydroxy[2-methyl-4-(2-methylpropoxy)phenyl]methylidene}-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-4-yl)pyrrolidine-2,3-dione

CAS 488810-38-4C₂₈H₃₅N₃O₅

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H29N3O5, CAS 460046-06-4

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 460046-06-4C₂₅H₂₉N₃O₅

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-1-(3-(4-morpholinyl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H26FN3O5, CAS 618073-02-2

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-1-(3-(4-morpholinyl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618073-02-2C₂₄H₂₆FN₃O₅

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H26FN3O4, CAS 618073-88-4

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618073-88-4C₂₄H₂₆FN₃O₄

(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C27H33N3O5, CAS 845901-91-9

(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

CAS 845901-91-9C₂₇H₃₃N₃O₅

(E)-[3-Methyl-4-(2-methylpropoxy)phenyl]-[1-(3-morpholin-4-ium-4-ylpropyl)-4,5-dioxo-2-pyridin-4-ylpyrrolidin-3-ylidene]methanolate chemical structure, C28H35N3O5, CAS 488092-87-1

(E)-[3-Methyl-4-(2-methylpropoxy)phenyl]-[1-(3-morpholin-4-ium-4-ylpropyl)-4,5-dioxo-2-pyridin-4-ylpyrrolidin-3-ylidene]methanolate

CAS 488092-87-1C₂₈H₃₅N₃O₅

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H33N3O5, CAS 510712-21-7

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 510712-21-7C₂₇H₃₃N₃O₅