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Murcko scaffold

Ring system with 4 rings and 29 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
16
With full pages
2
Scaffold SMILES

O=C1C(=O)N(CCCN2CCOCC2)C(c2cccnc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(CCCN2CCOCC2)C(c2cccnc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-Hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H35N3O5
3-Hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C28H35N3O5
3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H33N3O5
3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C27H33N3O5
4-(4-Chlorobenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H24ClN3O4, CAS 380159-12-6
4-(4-Chlorobenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one
CAS 380159-12-6C23H24ClN3O4
3-Hydroxy-4-(4-methylbenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H27N3O4, CAS 381171-11-5
3-Hydroxy-4-(4-methylbenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one
CAS 381171-11-5C24H27N3O4
3-(4-Bromobenzoyl)-4-hydroxy-1-(3-morpholinopropyl)-2-(3-pyridyl)-2H-pyrrol-5-one chemical structure, C23H24BrN3O4, CAS 380558-03-2
3-(4-Bromobenzoyl)-4-hydroxy-1-(3-morpholinopropyl)-2-(3-pyridyl)-2H-pyrrol-5-one
CAS 380558-03-2C23H24BrN3O4
3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C26H31N3O5, CAS 370871-20-8
3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one
CAS 370871-20-8C26H31N3O5
3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O5, CAS 460046-07-5
3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 460046-07-5C25H29N3O5
3-Hydroxy-1-[3-(4-morpholinyl)propyl]-4-(4-propoxybenzoyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H31N3O5, CAS 615271-63-1
3-Hydroxy-1-[3-(4-morpholinyl)propyl]-4-(4-propoxybenzoyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 615271-63-1C26H31N3O5
4-(3-Chloro-4-methoxybenzoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H26ClN3O5, CAS 636987-62-7
4-(3-Chloro-4-methoxybenzoyl)-3-hydroxy-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 636987-62-7C24H26ClN3O5
4-Benzoyl-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H25N3O4, CAS 380555-34-0
4-Benzoyl-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one
CAS 380555-34-0C23H25N3O4
3-Hydroxy-4-(4-isobutoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C28H35N3O5, CAS 487032-84-8
3-Hydroxy-4-(4-isobutoxy-3-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 487032-84-8C28H35N3O5
3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-(4-morpholinyl)propyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H33N3O5, CAS 510712-22-8
3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-(4-morpholinyl)propyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 510712-22-8C27H33N3O5
(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C27H33N3O5, CAS 846029-01-4
(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
CAS 846029-01-4C27H33N3O5
3-Hydroxy-4-(4-isopropoxy-2-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H33N3O5, CAS 609794-19-6
3-Hydroxy-4-(4-isopropoxy-2-methylbenzoyl)-1-[3-(4-morpholinyl)propyl]-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 609794-19-6C27H33N3O5
3-Hydroxy-4-[(2-hydroxy-4,5-dimethylphenyl)carbonyl]-1-(3-morpholin-4-ylpropyl)-5-(3-pyridyl)-3-pyrrolin-2-one chemical structure, C25H29N3O5, CAS 938032-32-7
3-Hydroxy-4-[(2-hydroxy-4,5-dimethylphenyl)carbonyl]-1-(3-morpholin-4-ylpropyl)-5-(3-pyridyl)-3-pyrrolin-2-one
CAS 938032-32-7C25H29N3O5
3-Hydroxy-4-(2-hydroxy-4,5-dimethylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O5
3-Hydroxy-4-(2-hydroxy-4,5-dimethylbenzoyl)-1-[3-(morpholin-4-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H29N3O5