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Murcko scaffold

Ring system with 3 rings and 12 atoms

20 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 12
Chemicals: 20
With full pages: 3

Scaffold SMILES

c1cc2n(n1)CCC(C1CC1)N2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1cc2n(n1)CCC(C1CC1)N2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

5-Cyclopropyl-4,5,6,7-tetrahydro-7-(trifluoromethyl)pyrazolo(1,5-a)pyrimidine-2-carboxylic acid chemical structure, C11H12F3N3O2, CAS 436088-39-0

5-Cyclopropyl-4,5,6,7-tetrahydro-7-(trifluoromethyl)pyrazolo(1,5-a)pyrimidine-2-carboxylic acid

CAS 436088-39-0C₁₁H₁₂F₃N₃O₂

4,5,6,7-Tetrahydro-5-(1-methylcyclopropyl)-7-(trifluoromethyl)pyrazolo(1,5-a)pyrimidine-2-carboxylic acid chemical structure, C12H14F3N3O2, CAS 436088-54-9

4,5,6,7-Tetrahydro-5-(1-methylcyclopropyl)-7-(trifluoromethyl)pyrazolo(1,5-a)pyrimidine-2-carboxylic acid

CAS 436088-54-9C₁₂H₁₄F₃N₃O₂

5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile chemical structure, C11H11F3N4, CAS 827588-14-7

5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

CAS 827588-14-7C₁₁H₁₁F₃N₄

5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine chemical structure, C10H12F3N3, CAS 827588-57-8

5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

CAS 827588-57-8C₁₀H₁₂F₃N₃

Ethyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo(1,5-a)pyrimidine-3-carboxylate chemical structure, C13H16F3N3O2, CAS 827591-57-1

Ethyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo(1,5-a)pyrimidine-3-carboxylate

CAS 827591-57-1C₁₃H₁₆F₃N₃O₂

5-Cyclopropyl-2-methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine chemical structure, C11H14F3N3, CAS 832739-41-0

5-Cyclopropyl-2-methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

CAS 832739-41-0C₁₁H₁₄F₃N₃

Ethyl 5-cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxylate chemical structure, C13H17F2N3O2, CAS 832740-92-8

Ethyl 5-cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxylate

CAS 832740-92-8C₁₃H₁₇F₂N₃O₂

(5R,7S)-5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile chemical structure, C11H11F3N4, CAS 2408937-64-2

(5R,7S)-5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

CAS 2408937-64-2C₁₁H₁₁F₃N₄

rac-Ethyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C13H17F2N3O2, CAS 2248307-07-3

rac-Ethyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 2248307-07-3C₁₃H₁₇F₂N₃O₂

Methyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C12H14F3N3O2, CAS 827590-95-4

Methyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 827590-95-4C₁₂H₁₄F₃N₃O₂

3-Chloro-5-cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C11H11ClF3N3O2, CAS 912771-84-7

3-Chloro-5-cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid

CAS 912771-84-7C₁₁H₁₁ClF₃N₃O₂

(5R,7S)-5-Cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C11H13F2N3O2, CAS 2187426-84-0

(5R,7S)-5-Cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 2187426-84-0C₁₁H₁₃F₂N₃O₂

rac-Methyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C12H15F2N3O2, CAS 2248320-83-2

rac-Methyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 2248320-83-2C₁₂H₁₅F₂N₃O₂

rac-tert-Butyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C15H21F2N3O2, CAS 2639371-25-6

rac-tert-Butyl (5R,7S)-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 2639371-25-6C₁₅H₂₁F₂N₃O₂

rac-(5R,7S)-4-[(tert-Butoxy)carbonyl]-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C16H21F2N3O4, CAS 2639378-87-1

rac-(5R,7S)-4-[(tert-Butoxy)carbonyl]-5-cyclopropyl-7-(difluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 2639378-87-1C₁₆H₂₁F₂N₃O₄

tert-Butyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C15H20F3N3O2, CAS 2639441-32-8

tert-Butyl 5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 2639441-32-8C₁₅H₂₀F₃N₃O₂

4-[(tert-Butoxy)carbonyl]-5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C16H20F3N3O4, CAS 2639413-33-3

4-[(tert-Butoxy)carbonyl]-5-cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 2639413-33-3C₁₆H₂₀F₃N₃O₄

5-Cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C11H12F3N3O2, CAS 912771-94-9

5-Cyclopropyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 912771-94-9C₁₁H₁₂F₃N₃O₂

5-Cyclopropyl-4-(2,2,2-trifluoroacetyl)-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C13H11F6N3O3, CAS 2680800-72-8

5-Cyclopropyl-4-(2,2,2-trifluoroacetyl)-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 2680800-72-8C₁₃H₁₁F₆N₃O₃

rac-(5R,7S)-5-Cyclopropyl-7-(difluoromethyl)-4-(2,2,2-trifluoroacetyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C13H12F5N3O3, CAS 2679832-82-5

rac-(5R,7S)-5-Cyclopropyl-7-(difluoromethyl)-4-(2,2,2-trifluoroacetyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 2679832-82-5C₁₃H₁₂F₅N₃O₃