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Murcko scaffold

Ring system with 3 rings and 23 atoms

80 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
80
With full pages
13
Scaffold SMILES

O=C(COc1ccccc1)Nc1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 80 chemicals

2-(4-Methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O2, CAS 640242-34-8
2-(4-Methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 640242-34-8C20H25N3O2
N-[4-(4-Methylpiperazin-1-yl)phenyl]-2-phenoxyacetamide chemical structure, C19H23N3O2, CAS 640242-28-0
N-[4-(4-Methylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
CAS 640242-28-0C19H23N3O2
2-(4-Bromophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22BrN3O2, CAS 573975-41-4
2-(4-Bromophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 573975-41-4C19H22BrN3O2
2-(4-Ethylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C21H27N3O2, CAS 640242-36-0
2-(4-Ethylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 640242-36-0C21H27N3O2
N-[4-(4-Methylpiperazin-1-yl)phenyl]-2-(4-propan-2-ylphenoxy)acetamide chemical structure, C22H29N3O2, CAS 640242-38-2
N-[4-(4-Methylpiperazin-1-yl)phenyl]-2-(4-propan-2-ylphenoxy)acetamide
CAS 640242-38-2C22H29N3O2
2-(4-Chlorophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22ClN3O2, CAS 640242-54-2
2-(4-Chlorophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 640242-54-2C19H22ClN3O2
2-(2-Chlorophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22ClN3O2, CAS 640242-56-4
2-(2-Chlorophenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 640242-56-4C19H22ClN3O2
2-Phenoxy-N-[4-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C21H25N3O3, CAS 688331-61-5
2-Phenoxy-N-[4-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 688331-61-5C21H25N3O3
N-[4-(4-Methylsulfonylpiperazin-1-yl)phenyl]-2-phenoxyacetamide chemical structure, C19H23N3O4S, CAS 674296-19-6
N-[4-(4-Methylsulfonylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
CAS 674296-19-6C19H23N3O4S
2-(4-Chlorophenoxy)-N-[4-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C21H24ClN3O3, CAS 688331-64-8
2-(4-Chlorophenoxy)-N-[4-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 688331-64-8C21H24ClN3O3
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-ethylphenoxy)acetamide chemical structure, C22H27N3O3, CAS 425606-11-7
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-ethylphenoxy)acetamide
CAS 425606-11-7C22H27N3O3
2-(4-Chloro-2-methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H24ClN3O2, CAS 689747-62-4
2-(4-Chloro-2-methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 689747-62-4C20H24ClN3O2
2-(4-Chlorophenoxy)-2-methyl-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]propanamide chemical structure, C21H26ClN3O4S, CAS 832119-44-5
2-(4-Chlorophenoxy)-2-methyl-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]propanamide
CAS 832119-44-5C21H26ClN3O4S
2-(2-Isopropyl-5-methylphenoxy)-N-{4-[4-(methylsulfonyl)-1-piperazinyl]phenyl}acetamide chemical structure, C23H31N3O4S, CAS 672913-07-4
2-(2-Isopropyl-5-methylphenoxy)-N-{4-[4-(methylsulfonyl)-1-piperazinyl]phenyl}acetamide
CAS 672913-07-4C23H31N3O4S
2-(2-Bromo-4,6-dimethylphenoxy)-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C21H26BrN3O4S, CAS 674359-91-2
2-(2-Bromo-4,6-dimethylphenoxy)-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 674359-91-2C21H26BrN3O4S
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(2-methylphenoxy)acetamide chemical structure, C21H25N3O3, CAS 590380-69-1
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(2-methylphenoxy)acetamide
CAS 590380-69-1C21H25N3O3
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chloro-2-methylphenoxy)acetamide chemical structure, C21H24ClN3O3, CAS 425609-10-5
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chloro-2-methylphenoxy)acetamide
CAS 425609-10-5C21H24ClN3O3
2-(4-Chloro-2-methylphenoxy)-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H24ClN3O4S, CAS 674350-45-9
2-(4-Chloro-2-methylphenoxy)-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 674350-45-9C20H24ClN3O4S
2-(3-Methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O2, CAS 640242-32-6
2-(3-Methylphenoxy)-N-[4-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 640242-32-6C20H25N3O2
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chlorophenoxy)acetamide chemical structure, C20H22ClN3O3, CAS 441314-14-3
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chlorophenoxy)acetamide
CAS 441314-14-3C20H22ClN3O3
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-bromophenoxy)acetamide chemical structure, C20H22BrN3O3, CAS 425626-87-5
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-bromophenoxy)acetamide
CAS 425626-87-5C20H22BrN3O3
N-[4-(4-Butanoylpiperazin-1-yl)-3-chlorophenyl]-2-(2-nitrophenoxy)acetamide chemical structure, C22H25ClN4O5, CAS 672944-43-3
N-[4-(4-Butanoylpiperazin-1-yl)-3-chlorophenyl]-2-(2-nitrophenoxy)acetamide
CAS 672944-43-3C22H25ClN4O5
2-(4-Bromophenoxy)-N-[4-(4-butanoylpiperazin-1-yl)-3-chlorophenyl]acetamide chemical structure, C22H25BrClN3O3, CAS 672914-38-4
2-(4-Bromophenoxy)-N-[4-(4-butanoylpiperazin-1-yl)-3-chlorophenyl]acetamide
CAS 672914-38-4C22H25BrClN3O3
N-[4-(4-Butanoylpiperazin-1-yl)-3-chlorophenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide chemical structure, C26H34ClN3O3, CAS 673495-89-1
N-[4-(4-Butanoylpiperazin-1-yl)-3-chlorophenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide
CAS 673495-89-1C26H34ClN3O3