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Murcko scaffold

Ring system with 4 rings and 24 atoms

41 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
41
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)N1CCC(c2ccccc2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCC(c2ccccc2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

1-Benzoyl-4-(4-bromophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline chemical structure, C25H24BrNO, CAS 331973-82-1
1-Benzoyl-4-(4-bromophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline
CAS 331973-82-1C25H24BrNO
(4-Methoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C26H27NO2, CAS 300587-51-3
(4-Methoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 300587-51-3C26H27NO2
[4-(4-Methoxyphenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl](phenyl)methanone chemical structure, C26H27NO2, CAS 300591-44-0
[4-(4-Methoxyphenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl](phenyl)methanone
CAS 300591-44-0C26H27NO2
(4-Fluorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone chemical structure, C25H24FNO, CAS 331254-67-2
(4-Fluorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone
CAS 331254-67-2C25H24FNO
(3,5-Dinitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C25H23N3O5, CAS 300589-85-9
(3,5-Dinitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 300589-85-9C25H23N3O5
(3-Fluorophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C25H24FNO, CAS 331840-69-8
(3-Fluorophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 331840-69-8C25H24FNO
(4-Chloro-3-nitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C25H23ClN2O3, CAS 305343-32-2
(4-Chloro-3-nitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 305343-32-2C25H23ClN2O3
(3-Methoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C26H27NO2, CAS 302333-69-3
(3-Methoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 302333-69-3C26H27NO2
(3,5-Dinitrophenyl)-[2,2,4-trimethyl-4-(4-methylphenyl)-3H-quinolin-1-yl]methanone chemical structure, C26H25N3O5, CAS 300389-40-6
(3,5-Dinitrophenyl)-[2,2,4-trimethyl-4-(4-methylphenyl)-3H-quinolin-1-yl]methanone
CAS 300389-40-6C26H25N3O5
(3-Bromophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone chemical structure, C25H24BrNO, CAS 331973-43-4
(3-Bromophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone
CAS 331973-43-4C25H24BrNO
(2,4-Dichlorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone chemical structure, C25H23Cl2NO, CAS 305343-45-7
(2,4-Dichlorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone
CAS 305343-45-7C25H23Cl2NO
1-(2,4-Dichlorobenzoyl)-2,2,4-trimethyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroquinoline chemical structure, C26H25Cl2NO, CAS 348132-02-5
1-(2,4-Dichlorobenzoyl)-2,2,4-trimethyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroquinoline
CAS 348132-02-5C26H25Cl2NO
(3,4,5-Trimethoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C28H31NO4, CAS 314039-57-1
(3,4,5-Trimethoxyphenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 314039-57-1C28H31NO4
(3,5-Dimethoxyphenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone chemical structure, C27H29NO3, CAS 377056-82-1
(3,5-Dimethoxyphenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone
CAS 377056-82-1C27H29NO3
(4-Chlorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone chemical structure, C25H24ClNO, CAS 121259-31-2
(4-Chlorophenyl)-(2,2,4-trimethyl-4-phenyl-3H-quinolin-1-yl)methanone
CAS 121259-31-2C25H24ClNO
(4-Nitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C25H24N2O3, CAS 121259-33-4
(4-Nitrophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 121259-33-4C25H24N2O3
(2-Chlorophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C25H24ClNO, CAS 303018-82-8
(2-Chlorophenyl)(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)methanone
CAS 303018-82-8C25H24ClNO
(3-Fluorophenyl)-[2,2,4-trimethyl-4-(4-methylphenyl)-3H-quinolin-1-yl]methanone chemical structure, C26H26FNO, CAS 305866-96-0
(3-Fluorophenyl)-[2,2,4-trimethyl-4-(4-methylphenyl)-3H-quinolin-1-yl]methanone
CAS 305866-96-0C26H26FNO
[4-(4-Bromophenyl)-2,2,4-trimethyl-6-nitro-3H-quinolin-1-yl]-phenylmethanone chemical structure, C25H23BrN2O3, CAS 305865-27-4
[4-(4-Bromophenyl)-2,2,4-trimethyl-6-nitro-3H-quinolin-1-yl]-phenylmethanone
CAS 305865-27-4C25H23BrN2O3
4-(4-Ethylphenyl)-1-(4-fluorobenzoyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline chemical structure, C27H28FNO, CAS 309265-55-2
4-(4-Ethylphenyl)-1-(4-fluorobenzoyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline
CAS 309265-55-2C27H28FNO
(2,4-Dichlorophenyl)-[4-(4-ethylphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]methanone chemical structure, C27H27Cl2NO, CAS 331640-15-4
(2,4-Dichlorophenyl)-[4-(4-ethylphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]methanone
CAS 331640-15-4C27H27Cl2NO
1-Benzoyl-4-(4-fluorophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline chemical structure, C25H24FNO, CAS 317840-64-5
1-Benzoyl-4-(4-fluorophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline
CAS 317840-64-5C25H24FNO
Phenyl-[2,2,4-trimethyl-4-(3-nitrophenyl)-3H-quinolin-1-yl]methanone chemical structure, C25H24N2O3, CAS 332019-21-3
Phenyl-[2,2,4-trimethyl-4-(3-nitrophenyl)-3H-quinolin-1-yl]methanone
CAS 332019-21-3C25H24N2O3
1-Benzoyl-4-(3-fluorophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline chemical structure, C25H24FNO, CAS 332019-22-4
1-Benzoyl-4-(3-fluorophenyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline
CAS 332019-22-4C25H24FNO