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Murcko scaffold

Ring system with 4 rings and 22 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
23
With full pages
4
Scaffold SMILES

c1ccc(C2CCCCN2Cc2cccc3[nH]ccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2CCCCN2Cc2cccc3[nH]ccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

(±)-4-(4-Methoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)-4-methylpiperidin-2-yl)benzamide chemical structure, C25H31N3O3, CAS 1644669-80-6
(±)-4-(4-Methoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)-4-methylpiperidin-2-yl)benzamide
CAS 1644669-80-6C25H31N3O3
4-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzoic acid chemical structure, C23H26N2O2, CAS 1644669-75-9
4-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzoic acid
CAS 1644669-75-9C23H26N2O2
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzenemethanol chemical structure, C23H28N2O, CAS 1644670-66-5
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzenemethanol
CAS 1644670-66-5C23H28N2O
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzamide chemical structure, C23H27N3O, CAS 1644670-65-4
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzamide
CAS 1644670-65-4C23H27N3O
4-[5-Methoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzamide chemical structure, C24H29N3O3, CAS 1644670-56-3
4-[5-Methoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzamide
CAS 1644670-56-3C24H29N3O3
Iptacopan impurity 7 chemical structure, C27H34N2O4, CAS 1644670-76-7
Iptacopan impurity 7
CAS 1644670-76-7C27H34N2O4
5,7-Dimethyl-4-[[2-[4-(methylsulfonyl)phenyl]-1-piperidinyl]methyl]-1H-indole chemical structure, C23H28N2O2S, CAS 1644669-68-0
5,7-Dimethyl-4-[[2-[4-(methylsulfonyl)phenyl]-1-piperidinyl]methyl]-1H-indole
CAS 1644669-68-0C23H28N2O2S
4-[[2-(4-Fluorophenyl)-4-methoxy-1-piperidinyl]methyl]-5,7-dimethyl-1H-indole chemical structure, C23H27FN2O, CAS 1644669-64-6
4-[[2-(4-Fluorophenyl)-4-methoxy-1-piperidinyl]methyl]-5,7-dimethyl-1H-indole
CAS 1644669-64-6C23H27FN2O
1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-phenyl-2-piperidinemethanol chemical structure, C23H28N2O, CAS 1644669-65-7
1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-phenyl-2-piperidinemethanol
CAS 1644669-65-7C23H28N2O
Iptacopan chemical structure, C25H30N2O4, CAS 1644670-37-0
Iptacopan
CAS 1644670-37-0C25H30N2O4
4-[(2R,4R)-4-Ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidyl]benzoic acid chemical structure, C25H30N2O4, CAS 1644670-39-2
4-[(2R,4R)-4-Ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidyl]benzoic acid
CAS 1644670-39-2C25H30N2O4
Iptacopan metabolite M2 chemical structure, C23H26N2O4, CAS 1644670-02-9
Iptacopan metabolite M2
CAS 1644670-02-9C23H26N2O4
5,7-Dimethyl-4-[(2-phenyl-1-piperidinyl)methyl]-1H-indole chemical structure, C22H26N2, CAS 1644669-53-3
5,7-Dimethyl-4-[(2-phenyl-1-piperidinyl)methyl]-1H-indole
CAS 1644669-53-3C22H26N2
4-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzenesulfonamide chemical structure, C22H27N3O2S, CAS 1644669-58-8
4-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzenesulfonamide
CAS 1644669-58-8C22H27N3O2S
Methyl 4-(1-((5,7-dimethyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoate chemical structure, C24H28N2O2, CAS 1644669-32-8
Methyl 4-(1-((5,7-dimethyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoate
CAS 1644669-32-8C24H28N2O2
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzoic acid methyl ester chemical structure, C24H28N2O2, CAS 1644668-98-3
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzoic acid methyl ester
CAS 1644668-98-3C24H28N2O2
Iptacopan hydrochloride anhydrous chemical structure, C25H31ClN2O4, CAS 1646321-63-2
Iptacopan hydrochloride anhydrous
CAS 1646321-63-2C25H31ClN2O4
Lge2H2A7FW chemical structure, C31H40N2O6, CAS 2361158-02-1
Lge2H2A7FW
CAS 2361158-02-1C31H40N2O6
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]-N-methylbenzenesulfonamide chemical structure, C23H29N3O2S, CAS 1644669-63-5
3-[1-[(5,7-Dimethyl-1H-indol-4-yl)methyl]-2-piperidinyl]-N-methylbenzenesulfonamide
CAS 1644669-63-5C23H29N3O2S
tert-Butyl 4-[[(2S,4R)-4-hydroxy-2-(4-methoxycarbonylphenyl)-1-piperidyl]methyl]-5-methoxy-7-methyl-indole-1-carboxylate chemical structure, C29H36N2O6, CAS 2920180-17-0
tert-Butyl 4-[[(2S,4R)-4-hydroxy-2-(4-methoxycarbonylphenyl)-1-piperidyl]methyl]-5-methoxy-7-methyl-indole-1-carboxylate
CAS 2920180-17-0C29H36N2O6
Iptacopan hydrochloride chemical structure, C25H33ClN2O5, CAS 2447007-60-3
Iptacopan hydrochloride
CAS 2447007-60-3C25H33ClN2O5
1-(1,1-Dimethylethyl) 4-[[(2S,4S)-2-(4-carboxyphenyl)-4-ethoxy-1-piperidinyl]methyl]-5-methoxy-7-methyl-1H-indole-1-carboxylate chemical structure, C30H38N2O6, CAS 2803364-77-2
1-(1,1-Dimethylethyl) 4-[[(2S,4S)-2-(4-carboxyphenyl)-4-ethoxy-1-piperidinyl]methyl]-5-methoxy-7-methyl-1H-indole-1-carboxylate
CAS 2803364-77-2C30H38N2O6
Orb3211460 chemical structure, C27H31F3N2O6, CAS 1644670-38-1
Orb3211460
CAS 1644670-38-1C27H31F3N2O6