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Murcko scaffold

Ring system with 4 rings and 24 atoms

186 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
186
With full pages
0
Scaffold SMILES

O=C(NCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 186 chemicals

2-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)acetic acid chemical structure, C23H22N4O5, CAS 2171862-64-7
2-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)acetic acid
CAS 2171862-64-7C23H22N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid chemical structure, C25H26N4O5, CAS 2171684-60-7
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid
CAS 2171684-60-7C25H26N4O5
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid chemical structure, C25H26N4O5, CAS 2171743-25-0
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid
CAS 2171743-25-0C25H26N4O5
(2S)-3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxypropanoic acid chemical structure, C24H24N4O6, CAS 2308474-30-6
(2S)-3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxypropanoic acid
CAS 2308474-30-6C24H24N4O6
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]butanoic acid chemical structure, C25H26N4O5, CAS 2171756-12-8
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]butanoic acid
CAS 2171756-12-8C25H26N4O5
(3R)-3-(5-Chloro-1-methyl-1H-pyrazol-4-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H20ClN3O4, CAS 2154862-44-7
(3R)-3-(5-Chloro-1-methyl-1H-pyrazol-4-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 2154862-44-7C22H20ClN3O4
(3S)-3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid chemical structure, C26H28N4O5, CAS 2308465-08-7
(3S)-3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid
CAS 2308465-08-7C26H28N4O5
(3S)-3-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)pentanoic acid chemical structure, C26H28N4O5, CAS 2171220-25-8
(3S)-3-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)pentanoic acid
CAS 2171220-25-8C26H28N4O5
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-N-methyl-2-(1-methyl-1H-pyrazol-4-yl)acetamido]acetic acid chemical structure, C24H24N4O5, CAS 2171694-32-7
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-N-methyl-2-(1-methyl-1H-pyrazol-4-yl)acetamido]acetic acid
CAS 2171694-32-7C24H24N4O5
2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]ethyl}sulfanyl)acetic acid chemical structure, C25H26N4O5S, CAS 2171754-45-1
2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]ethyl}sulfanyl)acetic acid
CAS 2171754-45-1C25H26N4O5S
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)-N-(propan-2-yl)acetamido]acetic acid chemical structure, C26H28N4O5, CAS 2171666-06-9
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)-N-(propan-2-yl)acetamido]acetic acid
CAS 2171666-06-9C26H28N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylbutanoic acid chemical structure, C26H28N4O5, CAS 2171559-15-0
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylbutanoic acid
CAS 2171559-15-0C26H28N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-N-methyl-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid chemical structure, C26H28N4O5, CAS 2171698-20-5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-N-methyl-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-methylpropanoic acid
CAS 2171698-20-5C26H28N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2,2-difluoropropanoic acid chemical structure, C24H22F2N4O5, CAS 2171606-76-9
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2,2-difluoropropanoic acid
CAS 2171606-76-9C24H22F2N4O5
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxybutanoic acid chemical structure, C25H26N4O6, CAS 2171587-02-1
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxybutanoic acid
CAS 2171587-02-1C25H26N4O6
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]but-2-enoic acid chemical structure, C25H24N4O5, CAS 2172616-08-7
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]but-2-enoic acid
CAS 2172616-08-7C25H24N4O5
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-3-methylbutanoic acid chemical structure, C26H28N4O5, CAS 2171696-28-7
4-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-3-methylbutanoic acid
CAS 2171696-28-7C26H28N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid chemical structure, C26H28N4O5, CAS 2171740-16-0
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid
CAS 2171740-16-0C26H28N4O5
2-{[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]oxy}acetic acid chemical structure, C23H22N4O6, CAS 2171734-17-9
2-{[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]oxy}acetic acid
CAS 2171734-17-9C23H22N4O6
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxy-2-methylpropanoic acid chemical structure, C25H26N4O6, CAS 2171742-22-4
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-2-hydroxy-2-methylpropanoic acid
CAS 2171742-22-4C25H26N4O6
5-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid chemical structure, C26H28N4O5, CAS 2171743-98-7
5-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]pentanoic acid
CAS 2171743-98-7C26H28N4O5
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-3-methylbutanoic acid chemical structure, C26H28N4O5, CAS 2171577-10-7
3-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]-3-methylbutanoic acid
CAS 2171577-10-7C26H28N4O5
2-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]ethoxy}acetic acid chemical structure, C25H26N4O6, CAS 2171673-34-8
2-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methyl-1H-pyrazol-4-yl)acetamido]ethoxy}acetic acid
CAS 2171673-34-8C25H26N4O6
(2S,3R)-2-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)-3-hydroxybutanoic acid chemical structure, C25H26N4O6, CAS 2171147-05-8
(2S,3R)-2-({4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)-3-hydroxybutanoic acid
CAS 2171147-05-8C25H26N4O6