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Murcko scaffold

Ring system with 4 rings and 28 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
8
With full pages
3
Scaffold SMILES

O=C(Nc1ccc2c(c1)OCCO2)C1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc2c(c1)OCCO2)C1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-methoxyphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C21H24N2O6S, CAS 444789-15-5
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-methoxyphenyl)sulfonylpiperidine-4-carboxamide
CAS 444789-15-5C21H24N2O6S
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-[(4-fluorophenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C20H21FN2O5S, CAS 510738-71-3
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-[(4-fluorophenyl)sulfonyl]piperidine-4-carboxamide
CAS 510738-71-3C20H21FN2O5S
1-((4-Chlorophenyl)sulfonyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperidine-4-carboxamide chemical structure, C20H21ClN2O5S, CAS 433947-42-3
1-((4-Chlorophenyl)sulfonyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperidine-4-carboxamide
CAS 433947-42-3C20H21ClN2O5S
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(2,4,6-trimethylphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C23H28N2O5S, CAS 701223-38-3
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(2,4,6-trimethylphenyl)sulfonylpiperidine-4-carboxamide
CAS 701223-38-3C23H28N2O5S
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(3,4-dimethoxyphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C22H26N2O7S, CAS 591224-73-6
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(3,4-dimethoxyphenyl)sulfonylpiperidine-4-carboxamide
CAS 591224-73-6C22H26N2O7S
1-(4-Bromophenyl)sulfonyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)piperidine-4-carboxamide chemical structure, C20H21BrN2O5S, CAS 433956-16-2
1-(4-Bromophenyl)sulfonyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)piperidine-4-carboxamide
CAS 433956-16-2C20H21BrN2O5S
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C21H24N2O5S, CAS 433956-75-3
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide
CAS 433956-75-3C21H24N2O5S
1-{[4-(Acetylamino)phenyl]sulfonyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-piperidinecarboxamide chemical structure, C22H25N3O6S, CAS 904511-59-7
1-{[4-(Acetylamino)phenyl]sulfonyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-piperidinecarboxamide
CAS 904511-59-7C22H25N3O6S