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Murcko scaffold

Ring system with 2 rings and 12 atoms

21 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 12
Chemicals: 21
With full pages: 6

Scaffold SMILES

C1=CC(=Nc2ccccc2)SC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C1=CC(=Nc2ccccc2)SC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

Ethyl 2-(2,4-dichloroanilino)-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H11Cl2NO3S, CAS 438196-92-0

Ethyl 2-(2,4-dichloroanilino)-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 438196-92-0C₁₃H₁₁Cl₂NO₃S

Methyl 2-[(3,4-dichlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H9Cl2NO3S, CAS 431886-80-5

Methyl 2-[(3,4-dichlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 431886-80-5C₁₂H₉Cl₂NO₃S

Methyl 4-oxo-2-(4-toluidino)-4,5-dihydro-3-thiophenecarboxylate chemical structure, C13H13NO3S, CAS 431054-59-0

Methyl 4-oxo-2-(4-toluidino)-4,5-dihydro-3-thiophenecarboxylate

CAS 431054-59-0C₁₃H₁₃NO₃S

Ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C14H15NO4S, CAS 297160-67-9

Ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 297160-67-9C₁₄H₁₅NO₄S

Ethyl 2-[(4-nitrophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H12N2O5S, CAS 5987-01-9

Ethyl 2-[(4-nitrophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 5987-01-9C₁₃H₁₂N₂O₅S

Ethyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H12FNO3S, CAS 297160-66-8

Ethyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 297160-66-8C₁₃H₁₂FNO₃S

Methyl 2-anilino-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H11NO3S, CAS 425650-26-6

Methyl 2-anilino-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 425650-26-6C₁₂H₁₁NO₃S

Ethyl 2-(3-chloroanilino)-4-oxothiophene-3-carboxylate chemical structure, C13H12ClNO3S, CAS 424813-15-0

Ethyl 2-(3-chloroanilino)-4-oxothiophene-3-carboxylate

CAS 424813-15-0C₁₃H₁₂ClNO₃S

Ethyl 2-anilino-4-oxo-4,5-dihydro-3-thiophenecarboxylate chemical structure, C13H13NO3S, CAS 78267-15-9

Ethyl 2-anilino-4-oxo-4,5-dihydro-3-thiophenecarboxylate

CAS 78267-15-9C₁₃H₁₃NO₃S

Methyl 4-oxo-2-{[3-(trifluoromethyl)phenyl]amino}-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H10F3NO3S, CAS 431072-84-3

Methyl 4-oxo-2-{[3-(trifluoromethyl)phenyl]amino}-4,5-dihydrothiophene-3-carboxylate

CAS 431072-84-3C₁₃H₁₀F₃NO₃S

Ethyl 4-oxo-2-(2-toluidino)-4,5-dihydro-3-thiophenecarboxylate chemical structure, C14H15NO3S, CAS 886360-76-5

Ethyl 4-oxo-2-(2-toluidino)-4,5-dihydro-3-thiophenecarboxylate

CAS 886360-76-5C₁₄H₁₅NO₃S

Methyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H10ClNO3S, CAS 431069-29-3

Methyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 431069-29-3C₁₂H₁₀ClNO₃S

Methyl 2-[(3-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H10ClNO3S, CAS 438195-65-4

Methyl 2-[(3-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 438195-65-4C₁₂H₁₀ClNO₃S

Ethyl 2-((4-chlorophenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H12ClNO3S, CAS 425629-94-3

Ethyl 2-((4-chlorophenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 425629-94-3C₁₃H₁₂ClNO₃S

Methyl 2-((4-methoxyphenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C13H13NO4S, CAS 430468-16-9

Methyl 2-((4-methoxyphenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 430468-16-9C₁₃H₁₃NO₄S

Methyl 2-[(4-nitrophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H10N2O5S, CAS 431924-15-1

Methyl 2-[(4-nitrophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 431924-15-1C₁₂H₁₀N₂O₅S

Methyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H10FNO3S, CAS 431072-54-7

Methyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 431072-54-7C₁₂H₁₀FNO₃S

Methyl 2-[(2-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C12H10FNO3S, CAS 431069-17-9

Methyl 2-[(2-fluorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 431069-17-9C₁₂H₁₀FNO₃S

Ethyl 2-[(2-ethylphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C15H17NO3S, CAS 895640-80-9

Ethyl 2-[(2-ethylphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 895640-80-9C₁₅H₁₇NO₃S

Ethyl 2-[(4-ethoxyphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate chemical structure, C15H17NO4S, CAS 893785-60-9

Ethyl 2-[(4-ethoxyphenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

CAS 893785-60-9C₁₅H₁₇NO₄S

4-Oxo-2-(phenylamino)-4,5-dihydrothiophene-3-carboxylic acid chemical structure, C11H9NO3S, CAS 3049471-14-6

4-Oxo-2-(phenylamino)-4,5-dihydrothiophene-3-carboxylic acid

CAS 3049471-14-6C₁₁H₉NO₃S