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Murcko scaffold

Ring system with 2 rings and 12 atoms

302 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 12
Chemicals: 302
With full pages: 75

Scaffold SMILES

c1ccc(Cc2cncs2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(Cc2cncs2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 302 chemicals

4-((2-Amino-4-methyl-5-thiazolyl)methyl)phenol chemical structure, C11H12N2OS, CAS 309727-50-2

4-((2-Amino-4-methyl-5-thiazolyl)methyl)phenol

CAS 309727-50-2C₁₁H₁₂N₂OS

N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]acetamide chemical structure, C12H11FN2OS, CAS 292160-95-3

N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]acetamide

CAS 292160-95-3C₁₂H₁₁FN₂OS

N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C12H10Cl2N2OS, CAS 304895-15-6

N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide

CAS 304895-15-6C₁₂H₁₀Cl₂N₂OS

5-Benzyl-1,3-thiazol-2-amine chemical structure, C10H10N2S, CAS 121952-97-4

5-Benzyl-1,3-thiazol-2-amine

CAS 121952-97-4C₁₀H₁₀N₂S

5-[(3-Nitrophenyl)methyl]-1,3-thiazol-2-amine chemical structure, C10H9N3O2S, CAS 207463-34-1

5-[(3-Nitrophenyl)methyl]-1,3-thiazol-2-amine

CAS 207463-34-1C₁₀H₉N₃O₂S

5-(3-Trifluoromethyl-benzyl)-thiazol-2-ylamine chemical structure, C11H9F3N2S, CAS 300819-51-6

5-(3-Trifluoromethyl-benzyl)-thiazol-2-ylamine

CAS 300819-51-6C₁₁H₉F₃N₂S

5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-amine chemical structure, C10H8Cl2N2S, CAS 306321-16-4

5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-amine

CAS 306321-16-4C₁₀H₈Cl₂N₂S

5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-amine chemical structure, C10H9ClN2S, CAS 290835-51-7

5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-amine

CAS 290835-51-7C₁₀H₉ClN₂S

5-(4-Fluoro-benzyl)-thiazol-2-ylamine chemical structure, C10H9FN2S, CAS 315241-39-5

5-(4-Fluoro-benzyl)-thiazol-2-ylamine

CAS 315241-39-5C₁₀H₉FN₂S

N-[5-[(3-Chlorophenyl)methyl]-2-thiazolyl]-2-cyanoacetamide chemical structure, C13H10ClN3OS, CAS 327062-17-9

N-[5-[(3-Chlorophenyl)methyl]-2-thiazolyl]-2-cyanoacetamide

CAS 327062-17-9C₁₃H₁₀ClN₃OS

5-((3-Methylphenyl)methyl)-1,3-thiazol-2-amine chemical structure, C11H12N2S, CAS 300827-54-7

5-((3-Methylphenyl)methyl)-1,3-thiazol-2-amine

CAS 300827-54-7C₁₁H₁₂N₂S

5-(2,3-Dichloro-benzyl)-thiazol-2-ylamine chemical structure, C10H8Cl2N2S, CAS 302548-99-8

5-(2,3-Dichloro-benzyl)-thiazol-2-ylamine

CAS 302548-99-8C₁₀H₈Cl₂N₂S

5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-amine chemical structure, C10H8Cl2N2S, CAS 405921-35-9

5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-amine

CAS 405921-35-9C₁₀H₈Cl₂N₂S

N-{5-[(4-Methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide chemical structure, C13H14N2O2S, CAS 304895-16-7

N-{5-[(4-Methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide

CAS 304895-16-7C₁₃H₁₄N₂O₂S

N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C12H11ClN2OS, CAS 304895-10-1

N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide

CAS 304895-10-1C₁₂H₁₁ClN₂OS

N-{5-[(3-Methylphenyl)methyl]-1,3-thiazol-2-yl}acetamide chemical structure, C13H14N2OS, CAS 304895-11-2

N-{5-[(3-Methylphenyl)methyl]-1,3-thiazol-2-yl}acetamide

CAS 304895-11-2C₁₃H₁₄N₂OS

N-[5-(4-Chlorobenzyl)-1,3-thiazol-2-yl]acetamide chemical structure, C12H11ClN2OS, CAS 304895-12-3

N-[5-(4-Chlorobenzyl)-1,3-thiazol-2-yl]acetamide

CAS 304895-12-3C₁₂H₁₁ClN₂OS

N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C12H11BrN2OS, CAS 304895-17-8

N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]acetamide

CAS 304895-17-8C₁₂H₁₁BrN₂OS

N-{5-[3-(Trifluoromethyl)benzyl]-1,3-thiazol-2-yl}acetamide chemical structure, C13H11F3N2OS, CAS 304895-19-0

N-{5-[3-(Trifluoromethyl)benzyl]-1,3-thiazol-2-yl}acetamide

CAS 304895-19-0C₁₃H₁₁F₃N₂OS

2-Chloro-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}acetamide chemical structure, C13H10ClF3N2OS, CAS 304895-20-3

2-Chloro-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}acetamide

CAS 304895-20-3C₁₃H₁₀ClF₃N₂OS

2-Chloro-N-(5-((4-methylphenyl)methyl)-1,3-thiazol-2-yl)acetamide chemical structure, C13H13ClN2OS, CAS 304895-21-4

2-Chloro-N-(5-((4-methylphenyl)methyl)-1,3-thiazol-2-yl)acetamide

CAS 304895-21-4C₁₃H₁₃ClN₂OS

2-Chloro-N-{5-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide chemical structure, C13H13ClN2O2S, CAS 304895-22-5

2-Chloro-N-{5-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide

CAS 304895-22-5C₁₃H₁₃ClN₂O₂S

N-(5-(4-Bromobenzyl)-1,3-thiazol-2-yl)-2-chloroacetamide chemical structure, C12H10BrClN2OS, CAS 304895-23-6

N-(5-(4-Bromobenzyl)-1,3-thiazol-2-yl)-2-chloroacetamide

CAS 304895-23-6C₁₂H₁₀BrClN₂OS

N-[5-(2,3-Dichlorobenzyl)-1,3-thiazol-2-yl]-3-methylbutanamide chemical structure, C15H16Cl2N2OS, CAS 304895-31-6

N-[5-(2,3-Dichlorobenzyl)-1,3-thiazol-2-yl]-3-methylbutanamide

CAS 304895-31-6C₁₅H₁₆Cl₂N₂OS