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Murcko scaffold

Ring system with 6 rings and 30 atoms

38 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
30
Chemicals
38
With full pages
10
Scaffold SMILES

c1ccc(-c2nc3ccc(-c4nc5ccc(N6CCNCC6)cc5[nH]4)cc3[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nc3ccc(-c4nc5ccc(N6CCNCC6)cc5[nH]4)cc3[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

Bisbenzimide chemical structure, C27H28N6O, CAS 23491-52-3
Bisbenzimide
CAS 23491-52-3C27H28N6O
Bisbenzimidazole chemical structure, C25H24N6O, CAS 23491-44-3
Bisbenzimidazole
CAS 23491-44-3C25H24N6O
Bisbenzimidazole trihydrochloride chemical structure, C25H27Cl3N6O, CAS 23491-45-4
Bisbenzimidazole trihydrochloride
CAS 23491-45-4C25H27Cl3N6O
Nuclear yellow chemical structure, C25H28Cl3N7O2S, CAS 74681-68-8
Nuclear yellow
CAS 74681-68-8C25H28Cl3N7O2S
4-(5-(4-Methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)benzenesulfonamide chemical structure, C25H25N7O2S, CAS 132869-82-0
4-(5-(4-Methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)benzenesulfonamide
CAS 132869-82-0C25H25N7O2S
2-(2-(3-Iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole chemical structure, C25H23IN6O, CAS 106050-84-4
2-(2-(3-Iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole
CAS 106050-84-4C25H23IN6O
N-(2-Chloroethyl) N-ethyl-4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)benzenamine chemical structure, C29H32ClN7, CAS 166546-18-5
N-(2-Chloroethyl) N-ethyl-4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)benzenamine
CAS 166546-18-5C29H32ClN7
N,N-Bis(2-chloroethyl)-4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)benzenamine chemical structure, C29H31Cl2N7, CAS 166546-19-6
N,N-Bis(2-chloroethyl)-4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)benzenamine
CAS 166546-19-6C29H31Cl2N7
Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, hydrochloride chemical structure, C25H25ClN6O, CAS 32089-25-1
Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, hydrochloride
CAS 32089-25-1C25H25ClN6O
Hoe 33378 chemical structure, C28H30N6O, CAS 23491-51-2
Hoe 33378
CAS 23491-51-2C28H30N6O
Methylproamine chemical structure, C28H31N7, CAS 188247-01-0
Methylproamine
CAS 188247-01-0C28H31N7
Hoechst 34580 chemical structure, C27H29N7, CAS 23555-00-2
Hoechst 34580
CAS 23555-00-2C27H29N7
meta-iodoHoechst 33258 chemical structure, C25H23IN6, CAS 158013-42-4
meta-iodoHoechst 33258
CAS 158013-42-4C25H23IN6
2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazole trihydrochloride trihydrate chemical structure, C27H37Cl3N6O4, CAS 881691-13-0
2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazole trihydrochloride trihydrate
CAS 881691-13-0C27H37Cl3N6O4
2-(4-Methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole chemical structure, C26H26N6, CAS 23554-98-5
2-(4-Methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
CAS 23554-98-5C26H26N6
Hoe 32021 chemical structure, C26H26N6O, CAS 23623-06-5
Hoe 32021
CAS 23623-06-5C26H26N6O
2'-(3,4-Dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzimidazole chemical structure, C27H28N6O2, CAS 188860-26-6
2'-(3,4-Dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzimidazole
CAS 188860-26-6C27H28N6O2
ortho-iodoHoechst 33258 chemical structure, C25H23IN6, CAS 158013-41-3
ortho-iodoHoechst 33258
CAS 158013-41-3C25H23IN6
meta-Hoechst chemical structure, C25H24N6O, CAS 132869-83-1
meta-Hoechst
CAS 132869-83-1C25H24N6O
para-iodoHoechst 33258 chemical structure, C25H23IN6, CAS 158013-43-5
para-iodoHoechst 33258
CAS 158013-43-5C25H23IN6
4-(4-(6-(4-Methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanoic acid chemical structure, C29H30N6O3, CAS 682809-60-5
4-(4-(6-(4-Methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanoic acid
CAS 682809-60-5C29H30N6O3
Orb2940674 chemical structure, C27H32Cl3N7, CAS 911004-45-0
Orb2940674
CAS 911004-45-0C27H32Cl3N7
4-[3-[6-[6-(4-Methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanoic acid chemical structure, C29H30N6O3, CAS 258843-62-8
4-[3-[6-[6-(4-Methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanoic acid
CAS 258843-62-8C29H30N6O3
Bisbenzimide ethoxide trihydrochloride chemical structure, C27H31Cl3N6O, CAS 875756-97-1
Bisbenzimide ethoxide trihydrochloride
CAS 875756-97-1C27H31Cl3N6O