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Murcko scaffold

Spiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione scaffold

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
15
With full pages
4
Scaffold SMILES

O=C1NC2(Nc3ccccc31)C(=O)Nc1ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione page
Murcko scaffold O=C1NC2(Nc3ccccc31)C(=O)Nc1ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

Spiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione chemical structure, C15H11N3O2, CAS 346457-57-6
Spiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione
CAS 346457-57-6C15H11N3O2
11-Prop-2-enylspiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione chemical structure, C18H15N3O2, CAS 309733-33-3
11-Prop-2-enylspiro[1,2,3-trihydroquinazoline-2,3'-indoline]-4,12-dione
CAS 309733-33-3C18H15N3O2
N,N-Diethyl-3',4'-dihydro-2,4'-dioxospiro(3H-indole-3,2'(1'H)-quinazoline)-1(2H)-acetamide chemical structure, C21H22N4O3, CAS 361465-02-3
N,N-Diethyl-3',4'-dihydro-2,4'-dioxospiro(3H-indole-3,2'(1'H)-quinazoline)-1(2H)-acetamide
CAS 361465-02-3C21H22N4O3
5-Bromo-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C15H10BrN3O2, CAS 717130-41-1
5-Bromo-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 717130-41-1C15H10BrN3O2
1-Methyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C16H13N3O2, CAS 895358-26-6
1-Methyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 895358-26-6C16H13N3O2
1-(3-Methylbutyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C20H21N3O2, CAS 903466-52-4
1-(3-Methylbutyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 903466-52-4C20H21N3O2
1-Ethyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C17H15N3O2, CAS 895834-60-3
1-Ethyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 895834-60-3C17H15N3O2
1-Butyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C19H19N3O2, CAS 908544-49-0
1-Butyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 908544-49-0C19H19N3O2
1-(2-Methylpropyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C19H19N3O2, CAS 908544-47-8
1-(2-Methylpropyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 908544-47-8C19H19N3O2
5-Bromo-1-methyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C16H12BrN3O2, CAS 895358-29-9
5-Bromo-1-methyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 895358-29-9C16H12BrN3O2
1-Propyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C18H17N3O2, CAS 908544-45-6
1-Propyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 908544-45-6C18H17N3O2
5-Bromo-1-(3-methylbutyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C20H20BrN3O2, CAS 945324-53-8
5-Bromo-1-(3-methylbutyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 945324-53-8C20H20BrN3O2
1-Pentyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C20H21N3O2, CAS 903466-28-4
1-Pentyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 903466-28-4C20H21N3O2
3'-Propan-2-ylspiro[1H-indole-3,2'-1H-quinazoline]-2,4'-dione chemical structure, C18H17N3O2, CAS 1354125-06-6
3'-Propan-2-ylspiro[1H-indole-3,2'-1H-quinazoline]-2,4'-dione
CAS 1354125-06-6C18H17N3O2
3'-(3-Methoxypropyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione chemical structure, C19H19N3O3, CAS 1354063-91-4
3'-(3-Methoxypropyl)-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
CAS 1354063-91-4C19H19N3O3