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Murcko scaffold

Ring system with 5 rings and 23 atoms

127 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
23
Chemicals
127
With full pages
24
Scaffold SMILES

O=C1C=C(C2CCC3C2CCC2C4CCCCC4CCC23)CO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=C(C2CCC3C2CCC2C4CCCCC4CCC23)CO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 127 chemicals

Strophanthidin chemical structure, C23H32O6, CAS 66-28-4
Strophanthidin
CAS 66-28-4C23H32O6
Sarmentogenin chemical structure, C23H34O5, CAS 76-28-8
Sarmentogenin
CAS 76-28-8C23H34O5
3-Epiuzarigenin chemical structure, C23H34O4, CAS 4972-49-0
3-Epiuzarigenin
CAS 4972-49-0C23H34O4
3-Epioleandrigenin chemical structure, C25H36O6, CAS 508-20-3
3-Epioleandrigenin
CAS 508-20-3C25H36O6
Periplogenin chemical structure, C23H34O5, CAS 514-39-6
Periplogenin
CAS 514-39-6C23H34O5
3-(Formyloxy)-14-hydroxycard-20(22)-enolide chemical structure, C24H34O5, CAS 1250-96-0
3-(Formyloxy)-14-hydroxycard-20(22)-enolide
CAS 1250-96-0C24H34O5
3,12-Bis(formyloxy)-14-hydroxycard-20(22)-enolide chemical structure, C25H34O7, CAS 1256-24-2
3,12-Bis(formyloxy)-14-hydroxycard-20(22)-enolide
CAS 1256-24-2C25H34O7
3-Formylgitaloxigenin chemical structure, C25H34O7, CAS 1256-58-2
3-Formylgitaloxigenin
CAS 1256-58-2C25H34O7
Digoxigenin chemical structure, C23H34O5, CAS 1672-46-4
Digoxigenin
CAS 1672-46-4C23H34O5
Strophanthidin 3-bromoacetate chemical structure, C25H33BrO7, CAS 4956-18-7
Strophanthidin 3-bromoacetate
CAS 4956-18-7C25H33BrO7
3,16-Bis(acetyloxy)-14-hydroxycard-20(22)-enolide chemical structure, C27H38O7, CAS 5996-03-2
3,16-Bis(acetyloxy)-14-hydroxycard-20(22)-enolide
CAS 5996-03-2C27H38O7
5-beta-Card-20(22)-enolide, 3-beta,14-dihydroxy-, 3-(acetamidoacetate) (ester) chemical structure, C27H39NO6, CAS 42716-84-7
5-beta-Card-20(22)-enolide, 3-beta,14-dihydroxy-, 3-(acetamidoacetate) (ester)
CAS 42716-84-7C27H39NO6
Strophanthidin-3-chloroacetate chemical structure, C25H33ClO7, CAS 52552-28-0
Strophanthidin-3-chloroacetate
CAS 52552-28-0C25H33ClO7
5-beta-Card-20(22)-enolide, 3-beta-(2-(acetyloxy)-1-oxopropoxy)-5,14-dihydroxy-19-oxo- chemical structure, C28H38O9, CAS 63979-64-6
5-beta-Card-20(22)-enolide, 3-beta-(2-(acetyloxy)-1-oxopropoxy)-5,14-dihydroxy-19-oxo-
CAS 63979-64-6C28H38O9
3-(Butanoyloxy)-5,14-dihydroxy-19-oxocard-20(22)-enolide chemical structure, C27H38O7, CAS 63979-65-7
3-(Butanoyloxy)-5,14-dihydroxy-19-oxocard-20(22)-enolide
CAS 63979-65-7C27H38O7
Strophanthidin-3-diethylaminoacetate chemical structure, C29H43NO7, CAS 63979-66-8
Strophanthidin-3-diethylaminoacetate
CAS 63979-66-8C29H43NO7
5,14-Dihydroxy-3-[(2-methylpropanoyl)oxy]-19-oxocard-20(22)-enolide chemical structure, C27H38O7, CAS 63979-70-4
5,14-Dihydroxy-3-[(2-methylpropanoyl)oxy]-19-oxocard-20(22)-enolide
CAS 63979-70-4C27H38O7
5,14-Dihydroxy-19-oxo-3-(pentanoyloxy)card-20(22)-enolide chemical structure, C28H40O7, CAS 63979-72-6
5,14-Dihydroxy-19-oxo-3-(pentanoyloxy)card-20(22)-enolide
CAS 63979-72-6C28H40O7
5-beta-Card-20(22)-enolide, 5,14-dihydroxy-3-beta-(3-methyl-1-oxobutoxy)-19-oxo-, (3-beta,5-beta)- chemical structure, C28H40O7, CAS 63979-73-7
5-beta-Card-20(22)-enolide, 5,14-dihydroxy-3-beta-(3-methyl-1-oxobutoxy)-19-oxo-, (3-beta,5-beta)-
CAS 63979-73-7C28H40O7
alpha-i-Valeryloxypropionyl-k-strophanthidin chemical structure, C31H44O9, CAS 63979-74-8
alpha-i-Valeryloxypropionyl-k-strophanthidin
CAS 63979-74-8C31H44O9
5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-, 3-acetate chemical structure, C25H36O6, CAS 80680-86-0
5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-, 3-acetate
CAS 80680-86-0C25H36O6
5-beta-Card-20(22)-enolide, 3-beta,12-beta,14,16-tetrahydroxy-, 16-acetate chemical structure, C25H36O7, CAS 102281-00-5
5-beta-Card-20(22)-enolide, 3-beta,12-beta,14,16-tetrahydroxy-, 16-acetate
CAS 102281-00-5C25H36O7
Uzarigenin chemical structure, C23H34O4, CAS 466-09-1
Uzarigenin
CAS 466-09-1C23H34O4
3beta,5,14,16beta-Tetrahydroxy-19-oxo-5betacard-20(22)-enolide 16-acetate chemical structure, C25H34O8, CAS 6980-15-0
3beta,5,14,16beta-Tetrahydroxy-19-oxo-5betacard-20(22)-enolide 16-acetate
CAS 6980-15-0C25H34O8